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Mixture for controlling insecticide-resistant malaria vectors.

Pennetier C, Costantini C, Corbel V, Licciardi S, Dabiré RK, Lapied B, Chandre F, Hougard JM - Emerging Infect. Dis. (2008)

Bottom Line: To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso.During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes.Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

View Article: PubMed Central - PubMed

Affiliation: Institut de Recherche pour le Développement, Cotonou, Bénin, France. c.pennetier@sussex.ac.uk

ABSTRACT
The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. The mixture seemed to not kill more susceptible genotypes for the kdr or Ace1R alleles. Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

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Comparative efficacy of repellent and insecticide–treated nets during dry (blue) and rainy (red) seasons. A) PM+DEET–treated nets; B) PM+KBR–treated nets; C) Kothrin–treated nets in each of 2 seasons. PM, pirimiphos methyl; DEET, diethyl-3-methylbenzamide; KBR, hydroxyethyl isobutyl piperidine carboxylate; Kothrin, 20% deltamethrin (Bayer Crop Science, Monheim am Rhein, Germany).
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Figure 1: Comparative efficacy of repellent and insecticide–treated nets during dry (blue) and rainy (red) seasons. A) PM+DEET–treated nets; B) PM+KBR–treated nets; C) Kothrin–treated nets in each of 2 seasons. PM, pirimiphos methyl; DEET, diethyl-3-methylbenzamide; KBR, hydroxyethyl isobutyl piperidine carboxylate; Kothrin, 20% deltamethrin (Bayer Crop Science, Monheim am Rhein, Germany).

Mentions: The analysis of deviance showed that the 3-way interaction term between time, treatment, and season was statistically significant (Fn,m = 4.705; p = 0.01), which indicates that the decrease in lethal effect over time was significantly different for treatments and between seasons. Hence, the minimal adequate model was that with a different curve relating the decrease in deaths with days posttreatment for each combination of treatments and seasons (Figures 1, 2). Accordingly, the estimates of the regression parameters for the 6 logistic curves are shown in Table 2, together with the inferred effective times in days posttreatment.


Mixture for controlling insecticide-resistant malaria vectors.

Pennetier C, Costantini C, Corbel V, Licciardi S, Dabiré RK, Lapied B, Chandre F, Hougard JM - Emerging Infect. Dis. (2008)

Comparative efficacy of repellent and insecticide–treated nets during dry (blue) and rainy (red) seasons. A) PM+DEET–treated nets; B) PM+KBR–treated nets; C) Kothrin–treated nets in each of 2 seasons. PM, pirimiphos methyl; DEET, diethyl-3-methylbenzamide; KBR, hydroxyethyl isobutyl piperidine carboxylate; Kothrin, 20% deltamethrin (Bayer Crop Science, Monheim am Rhein, Germany).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2630727&req=5

Figure 1: Comparative efficacy of repellent and insecticide–treated nets during dry (blue) and rainy (red) seasons. A) PM+DEET–treated nets; B) PM+KBR–treated nets; C) Kothrin–treated nets in each of 2 seasons. PM, pirimiphos methyl; DEET, diethyl-3-methylbenzamide; KBR, hydroxyethyl isobutyl piperidine carboxylate; Kothrin, 20% deltamethrin (Bayer Crop Science, Monheim am Rhein, Germany).
Mentions: The analysis of deviance showed that the 3-way interaction term between time, treatment, and season was statistically significant (Fn,m = 4.705; p = 0.01), which indicates that the decrease in lethal effect over time was significantly different for treatments and between seasons. Hence, the minimal adequate model was that with a different curve relating the decrease in deaths with days posttreatment for each combination of treatments and seasons (Figures 1, 2). Accordingly, the estimates of the regression parameters for the 6 logistic curves are shown in Table 2, together with the inferred effective times in days posttreatment.

Bottom Line: To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso.During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes.Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

View Article: PubMed Central - PubMed

Affiliation: Institut de Recherche pour le Développement, Cotonou, Bénin, France. c.pennetier@sussex.ac.uk

ABSTRACT
The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. The mixture seemed to not kill more susceptible genotypes for the kdr or Ace1R alleles. Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

Show MeSH
Related in: MedlinePlus