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Experience of Comamonas acidovorans keratitis with delayed onset and treatment response in immunocompromised cornea.

Lee SM, Kim MK, Lee JL, Wee WR, Lee JH - Korean J Ophthalmol (2008)

Bottom Line: We found some similarities in clinical courses of two cases.Comamonas acidovorans is known as a less virulent organism.However it can cause an indolent infection that responds slowly even to adequate antibiotics therapy in immunocompromised corneas.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To report 2 cases of Comamonas acidovorans keratitis in immunocompromised cornea.

Methods: A complete review of the medical records of the two cases of Comamonas acidovorans keratitis.

Results: We found some similarities in clinical courses of two cases. Both of them showed development of keratitis during the management with corticosteroids, delayed onset, slow response to antibiotics, and relatively less affected corneal epithelium.

Conclusions: Comamonas acidovorans is known as a less virulent organism. However it can cause an indolent infection that responds slowly even to adequate antibiotics therapy in immunocompromised corneas.

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Related in: MedlinePlus

Case 2 with C. acidovorans keratitis after penetrating keratoplasty. (A) Corneal ulceration with stromal infiltration was observed in the temporal area of previous donor cornea. (B) After 2 weeks of treatment, the epithelial defect was healed and the infiltration in corneal stroma had decreased. (C) Corneal allograft rejection developed after infection had been finally controlled.
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Figure 2: Case 2 with C. acidovorans keratitis after penetrating keratoplasty. (A) Corneal ulceration with stromal infiltration was observed in the temporal area of previous donor cornea. (B) After 2 weeks of treatment, the epithelial defect was healed and the infiltration in corneal stroma had decreased. (C) Corneal allograft rejection developed after infection had been finally controlled.

Mentions: A 49-year-old man had an alkali burn in his right eye and received an uneventful penetrating keratoplasty with allograft in February 2004. Topical corticosteroid was tapered continuously during the follow-up. However, in December 2005, we noted the appearance of inferotemporal conjunctival new vessels and increased the frequency of topical 1% prednisolone acetate to four times a day and added topical 0.5% cyclosporine four times a day. He came to our clinic in May 2006 for pain and decreased visual acuity in his right eye that started 5 days ago. The vision in his right eye was hand motion, and slit-lamp examination showed a corneal epithelial defect (5.0×2.5 mm), and stromal infiltration in the graft (Fig. 2A).


Experience of Comamonas acidovorans keratitis with delayed onset and treatment response in immunocompromised cornea.

Lee SM, Kim MK, Lee JL, Wee WR, Lee JH - Korean J Ophthalmol (2008)

Case 2 with C. acidovorans keratitis after penetrating keratoplasty. (A) Corneal ulceration with stromal infiltration was observed in the temporal area of previous donor cornea. (B) After 2 weeks of treatment, the epithelial defect was healed and the infiltration in corneal stroma had decreased. (C) Corneal allograft rejection developed after infection had been finally controlled.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629953&req=5

Figure 2: Case 2 with C. acidovorans keratitis after penetrating keratoplasty. (A) Corneal ulceration with stromal infiltration was observed in the temporal area of previous donor cornea. (B) After 2 weeks of treatment, the epithelial defect was healed and the infiltration in corneal stroma had decreased. (C) Corneal allograft rejection developed after infection had been finally controlled.
Mentions: A 49-year-old man had an alkali burn in his right eye and received an uneventful penetrating keratoplasty with allograft in February 2004. Topical corticosteroid was tapered continuously during the follow-up. However, in December 2005, we noted the appearance of inferotemporal conjunctival new vessels and increased the frequency of topical 1% prednisolone acetate to four times a day and added topical 0.5% cyclosporine four times a day. He came to our clinic in May 2006 for pain and decreased visual acuity in his right eye that started 5 days ago. The vision in his right eye was hand motion, and slit-lamp examination showed a corneal epithelial defect (5.0×2.5 mm), and stromal infiltration in the graft (Fig. 2A).

Bottom Line: We found some similarities in clinical courses of two cases.Comamonas acidovorans is known as a less virulent organism.However it can cause an indolent infection that responds slowly even to adequate antibiotics therapy in immunocompromised corneas.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To report 2 cases of Comamonas acidovorans keratitis in immunocompromised cornea.

Methods: A complete review of the medical records of the two cases of Comamonas acidovorans keratitis.

Results: We found some similarities in clinical courses of two cases. Both of them showed development of keratitis during the management with corticosteroids, delayed onset, slow response to antibiotics, and relatively less affected corneal epithelium.

Conclusions: Comamonas acidovorans is known as a less virulent organism. However it can cause an indolent infection that responds slowly even to adequate antibiotics therapy in immunocompromised corneas.

Show MeSH
Related in: MedlinePlus