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The effects of optic disc factors on retinal nerve fiber layer thickness measurement in children.

Jun JH, Lee SY - Korean J Ophthalmol (2008)

Bottom Line: As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area.As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner.Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine, Dongsan Medical Center, Keimyung University, Daegu, Korea.

ABSTRACT

Purpose: We analyzed the effect of the changes of the optic disc area (ODA) caused by the axial length and the refractive error, and the consequent changes of the distance from the optic disc margin to the circular scan (OD-CS) of Optical coherence tomography (OCT) on the measurement of the retinal nerve fiber layer thickness(RNFLT) were examined.

Methods: One hundred two eyes of 51 children (age range 4 to 15 years) were measured using OCT including the RNFLT. For the ODA and the OD-CS, the relative area formed by the ODA and the circular scan was obtained. In addition, the correlation of the refractive error and the axial length to the optic disc factors was assessed.

Results: As hyperopia progresses to myopia, the axial length became longer, the ODA became smaller (r=-0.442, p=0.000) and the OD-CS showed a tendency to increase (r=0.471, p=0.000). As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area.

Conclusions: As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner. Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.

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Relationship between axial length (mm) and age (years). Note the relationship showing an increase of the axia length with increasing age.
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Figure 2: Relationship between axial length (mm) and age (years). Note the relationship showing an increase of the axia length with increasing age.

Mentions: As the children's age increased, a trend for a decrease of the spherical equivalent from hyperopia to myopia was shown and the axial length had the tendency to be increased (r=-0.317, p=0.001, r=0.351, p=0.000) (Fig. 1, Fig. 2). Correlations of the ODA and the OD-CS with age were detected (r=-0.294, p=0.003, r=0.302, p-=0.002) (Fig. 3); nevertheless, these were not significantly correlated to the mean peripapillary RNFLT (r=0.134, p=0.181) (Table 3, Fig. 4).


The effects of optic disc factors on retinal nerve fiber layer thickness measurement in children.

Jun JH, Lee SY - Korean J Ophthalmol (2008)

Relationship between axial length (mm) and age (years). Note the relationship showing an increase of the axia length with increasing age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629932&req=5

Figure 2: Relationship between axial length (mm) and age (years). Note the relationship showing an increase of the axia length with increasing age.
Mentions: As the children's age increased, a trend for a decrease of the spherical equivalent from hyperopia to myopia was shown and the axial length had the tendency to be increased (r=-0.317, p=0.001, r=0.351, p=0.000) (Fig. 1, Fig. 2). Correlations of the ODA and the OD-CS with age were detected (r=-0.294, p=0.003, r=0.302, p-=0.002) (Fig. 3); nevertheless, these were not significantly correlated to the mean peripapillary RNFLT (r=0.134, p=0.181) (Table 3, Fig. 4).

Bottom Line: As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area.As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner.Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine, Dongsan Medical Center, Keimyung University, Daegu, Korea.

ABSTRACT

Purpose: We analyzed the effect of the changes of the optic disc area (ODA) caused by the axial length and the refractive error, and the consequent changes of the distance from the optic disc margin to the circular scan (OD-CS) of Optical coherence tomography (OCT) on the measurement of the retinal nerve fiber layer thickness(RNFLT) were examined.

Methods: One hundred two eyes of 51 children (age range 4 to 15 years) were measured using OCT including the RNFLT. For the ODA and the OD-CS, the relative area formed by the ODA and the circular scan was obtained. In addition, the correlation of the refractive error and the axial length to the optic disc factors was assessed.

Results: As hyperopia progresses to myopia, the axial length became longer, the ODA became smaller (r=-0.442, p=0.000) and the OD-CS showed a tendency to increase (r=0.471, p=0.000). As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area.

Conclusions: As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner. Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.

Show MeSH
Related in: MedlinePlus