Limits...
Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye.

Moon JW, Lee HJ, Shin KC, Wee WR, Lee JH, Kim MK - Korean J Ophthalmol (2007)

Bottom Line: After treatment, BUT and tear wettings were significantly prolonged in each group.While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033).While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Konkuk University Hospital, Seoul, Korea.

ABSTRACT

Purpose: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces.

Methods: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA).

Results: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033).

Conclusions: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.

Show MeSH

Related in: MedlinePlus

Before topical eyedrops, nucleus to cytoplasmic ratios (NCR) of conjunctival impression cytology were similar between the two groups. After assigned treatments (topical chondroitin sulfate with sodium hyaluronate (CS-HA) for right eyes and topical cyclosporine (CsA) for left eyes), there was significant NCR improvement in both eyes. There was no significant differences among treatment groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2629882&req=5

Figure 4: Before topical eyedrops, nucleus to cytoplasmic ratios (NCR) of conjunctival impression cytology were similar between the two groups. After assigned treatments (topical chondroitin sulfate with sodium hyaluronate (CS-HA) for right eyes and topical cyclosporine (CsA) for left eyes), there was significant NCR improvement in both eyes. There was no significant differences among treatment groups.

Mentions: Before treatment, mean GCD, NCR, and ECM were 5.36±1.02, 3.27±0.97, and 4.25±0.61 in topical CS-HA treated eyes and 5.47±1.71, 3.53±0.61, and 4.59±0.78 in topical CsA treated eyes, respectively with no significant difference between the two groups (p=0.795, 0.333, and 0.688, respectively). After scheduled treatment with topical CS-HA, there was significant improvement of GCD, NCR, and ECM (p=0.047, 0.035, and 0.018, respectively) (Fig. 3, 4, 5). Similarly, there was marked improvement of GCD, NCR, and ECM in topical CsA treated eyes (p=0.012, 0.025, and 0.027, respectively) (Fig. 3, 4, 5). GCDs increased more prominently in topical CsA treated eyes than in topical CS-HA treated eyes (p=0.033), while NCR and ECM showed no significant difference (p=0.721 and 0.439, respectively) (Fig. 3, 4, 5).


Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye.

Moon JW, Lee HJ, Shin KC, Wee WR, Lee JH, Kim MK - Korean J Ophthalmol (2007)

Before topical eyedrops, nucleus to cytoplasmic ratios (NCR) of conjunctival impression cytology were similar between the two groups. After assigned treatments (topical chondroitin sulfate with sodium hyaluronate (CS-HA) for right eyes and topical cyclosporine (CsA) for left eyes), there was significant NCR improvement in both eyes. There was no significant differences among treatment groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629882&req=5

Figure 4: Before topical eyedrops, nucleus to cytoplasmic ratios (NCR) of conjunctival impression cytology were similar between the two groups. After assigned treatments (topical chondroitin sulfate with sodium hyaluronate (CS-HA) for right eyes and topical cyclosporine (CsA) for left eyes), there was significant NCR improvement in both eyes. There was no significant differences among treatment groups.
Mentions: Before treatment, mean GCD, NCR, and ECM were 5.36±1.02, 3.27±0.97, and 4.25±0.61 in topical CS-HA treated eyes and 5.47±1.71, 3.53±0.61, and 4.59±0.78 in topical CsA treated eyes, respectively with no significant difference between the two groups (p=0.795, 0.333, and 0.688, respectively). After scheduled treatment with topical CS-HA, there was significant improvement of GCD, NCR, and ECM (p=0.047, 0.035, and 0.018, respectively) (Fig. 3, 4, 5). Similarly, there was marked improvement of GCD, NCR, and ECM in topical CsA treated eyes (p=0.012, 0.025, and 0.027, respectively) (Fig. 3, 4, 5). GCDs increased more prominently in topical CsA treated eyes than in topical CS-HA treated eyes (p=0.033), while NCR and ECM showed no significant difference (p=0.721 and 0.439, respectively) (Fig. 3, 4, 5).

Bottom Line: After treatment, BUT and tear wettings were significantly prolonged in each group.While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033).While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Konkuk University Hospital, Seoul, Korea.

ABSTRACT

Purpose: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces.

Methods: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer's test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer's test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA).

Results: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033).

Conclusions: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.

Show MeSH
Related in: MedlinePlus