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Analysis of aqueous humor calcium and phosphate from cataract eyes with and without diabetes mellitus.

Kim CJ, Choi SK - Korean J Ophthalmol (2007)

Bottom Line: In serum, calcium levels did not statistically differ between non-diabetics and diabetics.When non-diabetics were compared to the three diabetic subgroups, calcium levels did not differ in serum or aqueous humor, but the phosphorus levels in diabetics with proliferative diabetic retinopathy were significantly higher than those in non-diabetics, diabetics without diabetic retinopathy, and diabetics with non-proliferative diabetic retinopathy.This result may be related to hydrophilic acrylic IOL opacification.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul Veterans Hospital, Seoul, Korea.

ABSTRACT

Purpose: To compare the levels of calcium and phosphorus in the aqueous humor and serum of diabetics and non-diabetics.

Methods: We divided patients into two groups: seventy-six non-diabetic cataract patients and fifty-two diabetic cataract patients. The diabetic group was divided again into three subgroups: twenty-six patients with no diabetic retinopathy, thirteen patients with non-proliferative diabetic retinopathy, and thirteen patients with proliferative diabetic retinopathy. The authors compared the levels of calcium and phosphorus in the serum and aqueous humor of cataract patients. Statistic analysis was performed to form two comparisons: 1) a comparison between non-diabetics and diabetics and 2) a comparison among non-diabetics and the three subgroups of diabetics.

Results: In serum, calcium levels did not statistically differ between non-diabetics and diabetics. The phosphorus level was also not significantly different. In the aqueous humor, however, while calcium levels did not differ significantly, the phosphorus levels in diabetics were considerably higher than those in non-diabetics. When non-diabetics were compared to the three diabetic subgroups, calcium levels did not differ in serum or aqueous humor, but the phosphorus levels in diabetics with proliferative diabetic retinopathy were significantly higher than those in non-diabetics, diabetics without diabetic retinopathy, and diabetics with non-proliferative diabetic retinopathy.

Conclusions: The level of phosphorus in the aqueous humor and serum of diabetics was significantly increased, especially in diabetics with proliferative diabetic retinopathy. This result may be related to hydrophilic acrylic IOL opacification. Future studies regarding the pathogenic role of a high concentration of aqueous humor and serum phosphorus are required.

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Boxplot of the concentration of phosphorus in the aqueous humor.
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Figure 1: Boxplot of the concentration of phosphorus in the aqueous humor.

Mentions: The mean values of serum phosphorus and aqueous humor phosphorus were not significantly different among non-diabetics, diabetics without diabetic retinopathy, and those with non-proliferative diabetic retinopathy. However, the mean value of serum and aqueous humor phosphorus in diabetics with proliferative diabetic retinopathy was much higher than that in the other three groups (Tukey B, aqueous humor phosphorus p<0.05, serum phosphorus p<0.05) (Fig. 1. and Fig. 2.).


Analysis of aqueous humor calcium and phosphate from cataract eyes with and without diabetes mellitus.

Kim CJ, Choi SK - Korean J Ophthalmol (2007)

Boxplot of the concentration of phosphorus in the aqueous humor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629704&req=5

Figure 1: Boxplot of the concentration of phosphorus in the aqueous humor.
Mentions: The mean values of serum phosphorus and aqueous humor phosphorus were not significantly different among non-diabetics, diabetics without diabetic retinopathy, and those with non-proliferative diabetic retinopathy. However, the mean value of serum and aqueous humor phosphorus in diabetics with proliferative diabetic retinopathy was much higher than that in the other three groups (Tukey B, aqueous humor phosphorus p<0.05, serum phosphorus p<0.05) (Fig. 1. and Fig. 2.).

Bottom Line: In serum, calcium levels did not statistically differ between non-diabetics and diabetics.When non-diabetics were compared to the three diabetic subgroups, calcium levels did not differ in serum or aqueous humor, but the phosphorus levels in diabetics with proliferative diabetic retinopathy were significantly higher than those in non-diabetics, diabetics without diabetic retinopathy, and diabetics with non-proliferative diabetic retinopathy.This result may be related to hydrophilic acrylic IOL opacification.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul Veterans Hospital, Seoul, Korea.

ABSTRACT

Purpose: To compare the levels of calcium and phosphorus in the aqueous humor and serum of diabetics and non-diabetics.

Methods: We divided patients into two groups: seventy-six non-diabetic cataract patients and fifty-two diabetic cataract patients. The diabetic group was divided again into three subgroups: twenty-six patients with no diabetic retinopathy, thirteen patients with non-proliferative diabetic retinopathy, and thirteen patients with proliferative diabetic retinopathy. The authors compared the levels of calcium and phosphorus in the serum and aqueous humor of cataract patients. Statistic analysis was performed to form two comparisons: 1) a comparison between non-diabetics and diabetics and 2) a comparison among non-diabetics and the three subgroups of diabetics.

Results: In serum, calcium levels did not statistically differ between non-diabetics and diabetics. The phosphorus level was also not significantly different. In the aqueous humor, however, while calcium levels did not differ significantly, the phosphorus levels in diabetics were considerably higher than those in non-diabetics. When non-diabetics were compared to the three diabetic subgroups, calcium levels did not differ in serum or aqueous humor, but the phosphorus levels in diabetics with proliferative diabetic retinopathy were significantly higher than those in non-diabetics, diabetics without diabetic retinopathy, and diabetics with non-proliferative diabetic retinopathy.

Conclusions: The level of phosphorus in the aqueous humor and serum of diabetics was significantly increased, especially in diabetics with proliferative diabetic retinopathy. This result may be related to hydrophilic acrylic IOL opacification. Future studies regarding the pathogenic role of a high concentration of aqueous humor and serum phosphorus are required.

Show MeSH
Related in: MedlinePlus