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Diabetic macular edema before and after intravitreal triamcinolone injection.

Ramezani A, Tabatabaie H, Ahmadieh H - Korean J Ophthalmol (2007)

Bottom Line: Visual acuity changes within and between each period were not statistically significant.However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To compare intravitreal triamcinolone acetonide (IVT) versus natural course in refractory diabetic macular edema.

Methods: In a prospective interventional case series, twenty five eyes with refractory DME which had been allocated to the sham group of a previous clinical trial underwent new examination and optical coherence tomography about 9 months after their first enrollment. Twenty eyes that met the inclusion criteria, visual acuity (VA) < 20/50 and central macular thickness (CMT) > 200 microm, were treated by 4 mg IVT. Evaluations were repeated at 2 and 4 months post-injection to imitate the similar examination intervals after sham injection. Corrected visual acuity and macular thickness changes following IVT were compared to the corresponding changes after sham injection (the natural course).

Results: Visual acuity changes within and between each period were not statistically significant. Visual acuity decreased 0.08 & 0.09 logMAR by 2 months and 0.06 & 0.04 logMAR by 4 months after sham and IVT injections, respectively. The changes of macular thickness after IVT and sham intervention were not meaningful either. However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).

Conclusions: Concerning macular thickness, IVT has beneficial effect on refractory diabetic macular edema as opposed to observation. However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

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Mean central macular thickness changes after sham and IVT injections.
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Figure 3: Mean central macular thickness changes after sham and IVT injections.

Mentions: Until 4 months, there was a reduction (-127 μm) in mean CMT subsequent to IVT injection compared to a mild increase (+40 μm) after receiving sham intervention (Fig. 3); however, these differences within each intervention were not statistically significant (paired t test). Comparisons of thickness changes between the two interventions (independent sample t test) did not show significant difference either (P=0.119 for month 0 to 2, and P=0.968 for month 2 to 4), except in one stage. As shown in Table 2, the difference of changes between months 0 and 4 was significant (P=0.014), which implied on CMT reduction after IVT treatment in eyes which had been followed without any treatment for 9 months.


Diabetic macular edema before and after intravitreal triamcinolone injection.

Ramezani A, Tabatabaie H, Ahmadieh H - Korean J Ophthalmol (2007)

Mean central macular thickness changes after sham and IVT injections.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629697&req=5

Figure 3: Mean central macular thickness changes after sham and IVT injections.
Mentions: Until 4 months, there was a reduction (-127 μm) in mean CMT subsequent to IVT injection compared to a mild increase (+40 μm) after receiving sham intervention (Fig. 3); however, these differences within each intervention were not statistically significant (paired t test). Comparisons of thickness changes between the two interventions (independent sample t test) did not show significant difference either (P=0.119 for month 0 to 2, and P=0.968 for month 2 to 4), except in one stage. As shown in Table 2, the difference of changes between months 0 and 4 was significant (P=0.014), which implied on CMT reduction after IVT treatment in eyes which had been followed without any treatment for 9 months.

Bottom Line: Visual acuity changes within and between each period were not statistically significant.However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To compare intravitreal triamcinolone acetonide (IVT) versus natural course in refractory diabetic macular edema.

Methods: In a prospective interventional case series, twenty five eyes with refractory DME which had been allocated to the sham group of a previous clinical trial underwent new examination and optical coherence tomography about 9 months after their first enrollment. Twenty eyes that met the inclusion criteria, visual acuity (VA) < 20/50 and central macular thickness (CMT) > 200 microm, were treated by 4 mg IVT. Evaluations were repeated at 2 and 4 months post-injection to imitate the similar examination intervals after sham injection. Corrected visual acuity and macular thickness changes following IVT were compared to the corresponding changes after sham injection (the natural course).

Results: Visual acuity changes within and between each period were not statistically significant. Visual acuity decreased 0.08 & 0.09 logMAR by 2 months and 0.06 & 0.04 logMAR by 4 months after sham and IVT injections, respectively. The changes of macular thickness after IVT and sham intervention were not meaningful either. However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).

Conclusions: Concerning macular thickness, IVT has beneficial effect on refractory diabetic macular edema as opposed to observation. However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

Show MeSH
Related in: MedlinePlus