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Diabetic macular edema before and after intravitreal triamcinolone injection.

Ramezani A, Tabatabaie H, Ahmadieh H - Korean J Ophthalmol (2007)

Bottom Line: Visual acuity changes within and between each period were not statistically significant.However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To compare intravitreal triamcinolone acetonide (IVT) versus natural course in refractory diabetic macular edema.

Methods: In a prospective interventional case series, twenty five eyes with refractory DME which had been allocated to the sham group of a previous clinical trial underwent new examination and optical coherence tomography about 9 months after their first enrollment. Twenty eyes that met the inclusion criteria, visual acuity (VA) < 20/50 and central macular thickness (CMT) > 200 microm, were treated by 4 mg IVT. Evaluations were repeated at 2 and 4 months post-injection to imitate the similar examination intervals after sham injection. Corrected visual acuity and macular thickness changes following IVT were compared to the corresponding changes after sham injection (the natural course).

Results: Visual acuity changes within and between each period were not statistically significant. Visual acuity decreased 0.08 & 0.09 logMAR by 2 months and 0.06 & 0.04 logMAR by 4 months after sham and IVT injections, respectively. The changes of macular thickness after IVT and sham intervention were not meaningful either. However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).

Conclusions: Concerning macular thickness, IVT has beneficial effect on refractory diabetic macular edema as opposed to observation. However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

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Mean central macular thickness before, 2, 4 and about 8 months after the sham injection.
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Figure 2: Mean central macular thickness before, 2, 4 and about 8 months after the sham injection.

Mentions: The assessment of CMT between the prior phases and the time of recall are presented in Fig. 2. Although there was a mild increase in mean CMT during the follow up, paired t test did not show statistically significant changes between any of the compared times.


Diabetic macular edema before and after intravitreal triamcinolone injection.

Ramezani A, Tabatabaie H, Ahmadieh H - Korean J Ophthalmol (2007)

Mean central macular thickness before, 2, 4 and about 8 months after the sham injection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629697&req=5

Figure 2: Mean central macular thickness before, 2, 4 and about 8 months after the sham injection.
Mentions: The assessment of CMT between the prior phases and the time of recall are presented in Fig. 2. Although there was a mild increase in mean CMT during the follow up, paired t test did not show statistically significant changes between any of the compared times.

Bottom Line: Visual acuity changes within and between each period were not statistically significant.However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti Medical University, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To compare intravitreal triamcinolone acetonide (IVT) versus natural course in refractory diabetic macular edema.

Methods: In a prospective interventional case series, twenty five eyes with refractory DME which had been allocated to the sham group of a previous clinical trial underwent new examination and optical coherence tomography about 9 months after their first enrollment. Twenty eyes that met the inclusion criteria, visual acuity (VA) < 20/50 and central macular thickness (CMT) > 200 microm, were treated by 4 mg IVT. Evaluations were repeated at 2 and 4 months post-injection to imitate the similar examination intervals after sham injection. Corrected visual acuity and macular thickness changes following IVT were compared to the corresponding changes after sham injection (the natural course).

Results: Visual acuity changes within and between each period were not statistically significant. Visual acuity decreased 0.08 & 0.09 logMAR by 2 months and 0.06 & 0.04 logMAR by 4 months after sham and IVT injections, respectively. The changes of macular thickness after IVT and sham intervention were not meaningful either. However, the difference between thickness changes by 4 months (52+/-50 microm increase after sham vs. 262+/-115 microm reduction after IVT) was significant (P=0.014).

Conclusions: Concerning macular thickness, IVT has beneficial effect on refractory diabetic macular edema as opposed to observation. However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.

Show MeSH
Related in: MedlinePlus