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The effect of diffuse lamellar keratitis on visual acuity and contrast sensitivity following LASIK.

Han ES, Wee WR, Lee JH, Kim MK - Korean J Ophthalmol (2007)

Bottom Line: There was no difference in logMAR visual acuity between the DLK and non-DLK groups until the sixth postoperative month.However, CS was significantly decreased at 12 and 18 cycle/degree compared with preoperative values (p=0.043 and p=0.045, respectively) in the DLK group, whereas CS was significantly increased at 12 cycle/degree in the non-DLK group (p=0.042) at six months.DLK seemed to be strongly associated with a postoperative decrease of CS.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

ABSTRACT

Purpose: To evaluate visual outcome and the changes of contrast sensitivity (CS) after diffuse lamellar keratitis (DLK).

Methods: Using retrospective chart review, 48 eyes of 25 patients who underwent laser in situ keratomileusis (LASIK) with Visx S4 (VISX Inc., Santa Clara, CA) and M2 (Moria, France) and who were followed for at least six months were included. They were divided into two groups: DLK and non-DLK, by diagnosis of DLK or its absence after LASIK. Postoperative logMAR visual acuities and logCS measured using the VCTS 6500 (Vistech Consultants, Inc., Dayton, OH) were compared with preoperative values in the DLK and non-DLK groups at three and six months after LASIK.

Results: There was no difference in logMAR visual acuity between the DLK and non-DLK groups until the sixth postoperative month. However, CS was significantly decreased at 12 and 18 cycle/degree compared with preoperative values (p=0.043 and p=0.045, respectively) in the DLK group, whereas CS was significantly increased at 12 cycle/degree in the non-DLK group (p=0.042) at six months.

Conclusions: DLK seemed to be strongly associated with a postoperative decrease of CS.

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Related in: MedlinePlus

Comparison of the changes of log contrast sensitivities six months following LASIK, compared to preoperative level. A: changes of log contrast sensitivity (CS) in diffuse lamellar keratitis (DLK) group after six months following LASIK. CS in 12 and 18 CPD were significantly decreased at six months postoperatively in the DLK group (*p=0.043, 0.045, respectively from left, Wilcoxon signed rank test). B: changes of logCS in those without DLK. CS in 12 CPD was significantly increased at six months postoperatively in the non-DLK group (†p=0.042, Wilcoxon signed rank test). CS, contrast sensitivity; DLK, diffuse lamellar keratitis; CPD, cycles per degree.
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Figure 3: Comparison of the changes of log contrast sensitivities six months following LASIK, compared to preoperative level. A: changes of log contrast sensitivity (CS) in diffuse lamellar keratitis (DLK) group after six months following LASIK. CS in 12 and 18 CPD were significantly decreased at six months postoperatively in the DLK group (*p=0.043, 0.045, respectively from left, Wilcoxon signed rank test). B: changes of logCS in those without DLK. CS in 12 CPD was significantly increased at six months postoperatively in the non-DLK group (†p=0.042, Wilcoxon signed rank test). CS, contrast sensitivity; DLK, diffuse lamellar keratitis; CPD, cycles per degree.

Mentions: There was no difference of CS in all spatial frequencies preoperatively between the DLK and non-DLK groups (p>0.05, Mann-Whitney U test). Three months after LASIK, however, logCS in the DLK group was decreased by 0.091 in 1.5 cpd, 0.028 in 3 cpd, 0.026 in 6 cpd, 0.251 in 12 cpd, and 0.112 in 18 cpd. The decrease of logCS in 12 cpd was statistically significant in the DLK group at three months postoperatively (p=0.023, Wilcoxon signed rank test). On the contrary, logCS in the non-DLK group was increased by 0.025 in 1.5 cpd, 0.033 in 3 cpd, 0.019 in 6 cpd, 0.028 in 12 cpd, and a 0.002 in 18 cpd, but none were statistically significant (p>0.05, Wilcoxon signed rank test) at three months (Fig. 2). Six months after LASIK, in the DLK group, there was a significant decrease of 0.277 in 12 cpd, 0.261 in 18 cpd (p=0.043, 0.045, Wilcoxon signed rank test, respectively), and insignificant changes with an increase of 0.010 in 1.5 cpd and a decrease of 0.196 in 3 cpd and 0.490 in 6 cpd. On the contrary, the changes of logCS in the non-DLK group showed marked increases of 0.043 in 1.5 cpd, 0.041 in 3 cpd, 0.127 in 6 cpd, 0.410 in 12 cpd, and 0.049 in 18 cpd, with the increase in 12 cpd being statistically significant (p=0.042, Wilcoxon signed rank test) (Fig. 3). When logCS of the grade 1 DLK eyes with that of the non-DLK eyes was compared, there was no significant difference in preoperative logCS (p>0.05, Mann-Whitney U test). But the decrease of logCS in 12 cpd was statistically significant at three and six months postoperatively (p=0.037 and 0.009, respectively, Mann-Whitney U test).


The effect of diffuse lamellar keratitis on visual acuity and contrast sensitivity following LASIK.

Han ES, Wee WR, Lee JH, Kim MK - Korean J Ophthalmol (2007)

Comparison of the changes of log contrast sensitivities six months following LASIK, compared to preoperative level. A: changes of log contrast sensitivity (CS) in diffuse lamellar keratitis (DLK) group after six months following LASIK. CS in 12 and 18 CPD were significantly decreased at six months postoperatively in the DLK group (*p=0.043, 0.045, respectively from left, Wilcoxon signed rank test). B: changes of logCS in those without DLK. CS in 12 CPD was significantly increased at six months postoperatively in the non-DLK group (†p=0.042, Wilcoxon signed rank test). CS, contrast sensitivity; DLK, diffuse lamellar keratitis; CPD, cycles per degree.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629693&req=5

Figure 3: Comparison of the changes of log contrast sensitivities six months following LASIK, compared to preoperative level. A: changes of log contrast sensitivity (CS) in diffuse lamellar keratitis (DLK) group after six months following LASIK. CS in 12 and 18 CPD were significantly decreased at six months postoperatively in the DLK group (*p=0.043, 0.045, respectively from left, Wilcoxon signed rank test). B: changes of logCS in those without DLK. CS in 12 CPD was significantly increased at six months postoperatively in the non-DLK group (†p=0.042, Wilcoxon signed rank test). CS, contrast sensitivity; DLK, diffuse lamellar keratitis; CPD, cycles per degree.
Mentions: There was no difference of CS in all spatial frequencies preoperatively between the DLK and non-DLK groups (p>0.05, Mann-Whitney U test). Three months after LASIK, however, logCS in the DLK group was decreased by 0.091 in 1.5 cpd, 0.028 in 3 cpd, 0.026 in 6 cpd, 0.251 in 12 cpd, and 0.112 in 18 cpd. The decrease of logCS in 12 cpd was statistically significant in the DLK group at three months postoperatively (p=0.023, Wilcoxon signed rank test). On the contrary, logCS in the non-DLK group was increased by 0.025 in 1.5 cpd, 0.033 in 3 cpd, 0.019 in 6 cpd, 0.028 in 12 cpd, and a 0.002 in 18 cpd, but none were statistically significant (p>0.05, Wilcoxon signed rank test) at three months (Fig. 2). Six months after LASIK, in the DLK group, there was a significant decrease of 0.277 in 12 cpd, 0.261 in 18 cpd (p=0.043, 0.045, Wilcoxon signed rank test, respectively), and insignificant changes with an increase of 0.010 in 1.5 cpd and a decrease of 0.196 in 3 cpd and 0.490 in 6 cpd. On the contrary, the changes of logCS in the non-DLK group showed marked increases of 0.043 in 1.5 cpd, 0.041 in 3 cpd, 0.127 in 6 cpd, 0.410 in 12 cpd, and 0.049 in 18 cpd, with the increase in 12 cpd being statistically significant (p=0.042, Wilcoxon signed rank test) (Fig. 3). When logCS of the grade 1 DLK eyes with that of the non-DLK eyes was compared, there was no significant difference in preoperative logCS (p>0.05, Mann-Whitney U test). But the decrease of logCS in 12 cpd was statistically significant at three and six months postoperatively (p=0.037 and 0.009, respectively, Mann-Whitney U test).

Bottom Line: There was no difference in logMAR visual acuity between the DLK and non-DLK groups until the sixth postoperative month.However, CS was significantly decreased at 12 and 18 cycle/degree compared with preoperative values (p=0.043 and p=0.045, respectively) in the DLK group, whereas CS was significantly increased at 12 cycle/degree in the non-DLK group (p=0.042) at six months.DLK seemed to be strongly associated with a postoperative decrease of CS.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

ABSTRACT

Purpose: To evaluate visual outcome and the changes of contrast sensitivity (CS) after diffuse lamellar keratitis (DLK).

Methods: Using retrospective chart review, 48 eyes of 25 patients who underwent laser in situ keratomileusis (LASIK) with Visx S4 (VISX Inc., Santa Clara, CA) and M2 (Moria, France) and who were followed for at least six months were included. They were divided into two groups: DLK and non-DLK, by diagnosis of DLK or its absence after LASIK. Postoperative logMAR visual acuities and logCS measured using the VCTS 6500 (Vistech Consultants, Inc., Dayton, OH) were compared with preoperative values in the DLK and non-DLK groups at three and six months after LASIK.

Results: There was no difference in logMAR visual acuity between the DLK and non-DLK groups until the sixth postoperative month. However, CS was significantly decreased at 12 and 18 cycle/degree compared with preoperative values (p=0.043 and p=0.045, respectively) in the DLK group, whereas CS was significantly increased at 12 cycle/degree in the non-DLK group (p=0.042) at six months.

Conclusions: DLK seemed to be strongly associated with a postoperative decrease of CS.

Show MeSH
Related in: MedlinePlus