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Optical coherence tomographic finding in a case of macular coloboma.

Oh JY, Yu YS, Hwang JM, Park KH - Korean J Ophthalmol (2007)

Bottom Line: The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an absence of retinal pigment epithelium and choroid in the lesion.FA showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage.The OCT can be beneficial to confirm the diagnosis of macular coloboma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, and Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Purpose: To report the optical coherence tomography (OCT) findings in a patient with unilateral macular coloboma.

Methods: A 12-year-old male was presented with macular coloboma in the left eye. The optical coherence tomography was performed with fluorescein angiography (FA).

Results: The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an absence of retinal pigment epithelium and choroid in the lesion. FA showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage.

Conclusions: The OCT can be beneficial to confirm the diagnosis of macular coloboma.

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Related in: MedlinePlus

Color fundus photography shows a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the macula (A). Red-free retinal nerve fiber layer photography shows intact papillomacular bundle around the lesion (B). Large choroidal vessels and bared sclera are observed at the base. Fluorescence angiography shows hypofluorescence corresponding to the size of the lesion in both early (C) and late frames (D) without leakage of dye.
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Figure 1: Color fundus photography shows a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the macula (A). Red-free retinal nerve fiber layer photography shows intact papillomacular bundle around the lesion (B). Large choroidal vessels and bared sclera are observed at the base. Fluorescence angiography shows hypofluorescence corresponding to the size of the lesion in both early (C) and late frames (D) without leakage of dye.

Mentions: A 12-year-old boy was referred to our clinic for the evaluation of a macular lesion in the left eye. The past ocular and medical history was non-contributory. The best-corrected visual acuities were 20/20 in the right eye and 20/40 with -0.5 + 0.25 × 180 in the left eye. The anterior segment examination was unremarkable. The fundus examination of the left eye showed a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the foveal center with large choroidal vessels and bared sclera at the base (Fig. 1A). The lesion was approximately four disc diameters (DD) in width and two DD in height, and the retinal vessels were undisturbed at the margin. On red-free retinal nerve fiber layer photography, papillomacular bundle were not interrupted surrounding the lesion (Fig. 1B). Fluorescein angiography (FA) showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage (Fig. 1C, 1D). The color vision test with the Titmus test and the visual evoked potentials were normal. The immunologic tests including toxoplasmosis, rubella, syphilis, cytomegalovirus, herpes virus and human immunodeficiency virus were all negative. The OCT (STRATUSOCT, Carl Zeiss Meditec, Inc., Dublin, CA) showed a crater-like depression accompanying atrophic neurosensory retina, and an absence of retinal pigment epithelium (RPE) and choroid in the lesion. Increased backscattering due to bare sclera and choroidal vessels were found (Fig. 2A, 2B).


Optical coherence tomographic finding in a case of macular coloboma.

Oh JY, Yu YS, Hwang JM, Park KH - Korean J Ophthalmol (2007)

Color fundus photography shows a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the macula (A). Red-free retinal nerve fiber layer photography shows intact papillomacular bundle around the lesion (B). Large choroidal vessels and bared sclera are observed at the base. Fluorescence angiography shows hypofluorescence corresponding to the size of the lesion in both early (C) and late frames (D) without leakage of dye.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2629682&req=5

Figure 1: Color fundus photography shows a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the macula (A). Red-free retinal nerve fiber layer photography shows intact papillomacular bundle around the lesion (B). Large choroidal vessels and bared sclera are observed at the base. Fluorescence angiography shows hypofluorescence corresponding to the size of the lesion in both early (C) and late frames (D) without leakage of dye.
Mentions: A 12-year-old boy was referred to our clinic for the evaluation of a macular lesion in the left eye. The past ocular and medical history was non-contributory. The best-corrected visual acuities were 20/20 in the right eye and 20/40 with -0.5 + 0.25 × 180 in the left eye. The anterior segment examination was unremarkable. The fundus examination of the left eye showed a sharply-demarcated, oval-shaped, excavated lesion involving the temporal half of the foveal center with large choroidal vessels and bared sclera at the base (Fig. 1A). The lesion was approximately four disc diameters (DD) in width and two DD in height, and the retinal vessels were undisturbed at the margin. On red-free retinal nerve fiber layer photography, papillomacular bundle were not interrupted surrounding the lesion (Fig. 1B). Fluorescein angiography (FA) showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage (Fig. 1C, 1D). The color vision test with the Titmus test and the visual evoked potentials were normal. The immunologic tests including toxoplasmosis, rubella, syphilis, cytomegalovirus, herpes virus and human immunodeficiency virus were all negative. The OCT (STRATUSOCT, Carl Zeiss Meditec, Inc., Dublin, CA) showed a crater-like depression accompanying atrophic neurosensory retina, and an absence of retinal pigment epithelium (RPE) and choroid in the lesion. Increased backscattering due to bare sclera and choroidal vessels were found (Fig. 2A, 2B).

Bottom Line: The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an absence of retinal pigment epithelium and choroid in the lesion.FA showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage.The OCT can be beneficial to confirm the diagnosis of macular coloboma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, and Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT

Purpose: To report the optical coherence tomography (OCT) findings in a patient with unilateral macular coloboma.

Methods: A 12-year-old male was presented with macular coloboma in the left eye. The optical coherence tomography was performed with fluorescein angiography (FA).

Results: The OCT revealed the crater-like depression in the macula, demonstrating atrophic neurosensory retina, and an absence of retinal pigment epithelium and choroid in the lesion. FA showed hypofluorescence corresponding to the size of the lesion in both early and late frames without leakage of dye at any stage.

Conclusions: The OCT can be beneficial to confirm the diagnosis of macular coloboma.

Show MeSH
Related in: MedlinePlus