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Comparison of CT-guided sclerotherapy with using 95% ethanol and 20% hypertonic saline for managing simple renal cyst.

Egilmez H, Gok V, Oztoprak I, Atalar M, Cetin A, Arslan M, Gultekin Y, Solak O - Korean J Radiol (2007 Nov-Dec)

Bottom Line: Treatment success was determined six months later with follow-up clinical evaluation and performing ultrasonography.The complete regression ratio of the ethanol group was significantly higher (94% versus 72%, respectively) than that of the HS group.The failure ratio of the ethanol group was significantly lower (3% versus 25%, respectively) than that of the HS group.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Cumhuriyet University School of Medicine, Sivas, Turkey. hegilmez@cumhuriyet.edu.tr

ABSTRACT

Objective: We wanted to compare the efficacies of 95% ethanol and 20% hypertonic saline (HS) sclerotherapies that were performed in a single session under CT guidance for the management of simple renal cysts.

Materials and methods: A prospective series of 74 consecutive patients (average age: 57.6 +/- 8.1 years) with simple renal cysts were enrolled in this study. They were randomized into two groups and 95% ethanol or 20% HS, respectively, corresponding to 25% of the aspiration volume, was injected. Treatment success was determined six months later with follow-up clinical evaluation and performing ultrasonography.

Results: The sclerotherapy was accepted as technically successful without major complications in all except two patients who were excluded because of a communication between the simple renal cyst and the pelvicalyceal collecting system. Thirty-six patients in the ethanol group received sclerotherapy with 95% ethanol and 36 patients in the HS group underwent sclerotherapy with 20% HS. The complete regression ratio of the ethanol group was significantly higher (94% versus 72%, respectively) than that of the HS group. There was one patient with partial regression in each group. The failure ratio of the ethanol group was significantly lower (3% versus 25%, respectively) than that of the HS group.

Conclusion: Ethanol sclerotherapy under CT guidance is a successful and safe procedure and it can be used for the treatment of simple renal cysts. Sclerotherapy with 95% ethanol is more effective than 20% HS sclerotherapy. Sclerotherapy with HS may be an option for patients preferring to undergo a less painful treatment procedure.

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Related in: MedlinePlus

The number of patients, with complete and partial regression and failure at six months follow-up after sclerotherapy, in the ethanol and hypertonic saline groups. Their percentages are also presented.aP = 0.024 vs. the complete regression ratio of the hypertonic saline group with using Fisher's exact test.bP = 0.014 vs. the failure ratio of the hypertonic saline group with using Fisher's exact test.
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Figure 3: The number of patients, with complete and partial regression and failure at six months follow-up after sclerotherapy, in the ethanol and hypertonic saline groups. Their percentages are also presented.aP = 0.024 vs. the complete regression ratio of the hypertonic saline group with using Fisher's exact test.bP = 0.014 vs. the failure ratio of the hypertonic saline group with using Fisher's exact test.

Mentions: Figure 3 displays the number of patients in the ethanol and hypertonic saline groups with complete and partial regression, and those with failure at the follow-up six months after sclerotherapy. The number of patients of the ethanol and hypertonic saline groups with complete regression were 34 and 26, respectively. The complete regression ratio of the ethanol group was significantly higher (94% vs. 72%, respectively) than that of the hypertonic saline group (p = 0.024). There was one patient each with partial regression in both the ethanol and hypertonic saline groups. The partial regression ratios of the ethanol and hypertonic saline groups were similar (3% vs. 3%, respectively). The number of failures of the ethanol and hypertonic saline groups was one and nine, respectively. The failure ratio of the ethanol group was significantly lower (3% vs. 25%, respectively) than that of the hypertonic saline group (p = 0.014).


Comparison of CT-guided sclerotherapy with using 95% ethanol and 20% hypertonic saline for managing simple renal cyst.

Egilmez H, Gok V, Oztoprak I, Atalar M, Cetin A, Arslan M, Gultekin Y, Solak O - Korean J Radiol (2007 Nov-Dec)

The number of patients, with complete and partial regression and failure at six months follow-up after sclerotherapy, in the ethanol and hypertonic saline groups. Their percentages are also presented.aP = 0.024 vs. the complete regression ratio of the hypertonic saline group with using Fisher's exact test.bP = 0.014 vs. the failure ratio of the hypertonic saline group with using Fisher's exact test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627454&req=5

Figure 3: The number of patients, with complete and partial regression and failure at six months follow-up after sclerotherapy, in the ethanol and hypertonic saline groups. Their percentages are also presented.aP = 0.024 vs. the complete regression ratio of the hypertonic saline group with using Fisher's exact test.bP = 0.014 vs. the failure ratio of the hypertonic saline group with using Fisher's exact test.
Mentions: Figure 3 displays the number of patients in the ethanol and hypertonic saline groups with complete and partial regression, and those with failure at the follow-up six months after sclerotherapy. The number of patients of the ethanol and hypertonic saline groups with complete regression were 34 and 26, respectively. The complete regression ratio of the ethanol group was significantly higher (94% vs. 72%, respectively) than that of the hypertonic saline group (p = 0.024). There was one patient each with partial regression in both the ethanol and hypertonic saline groups. The partial regression ratios of the ethanol and hypertonic saline groups were similar (3% vs. 3%, respectively). The number of failures of the ethanol and hypertonic saline groups was one and nine, respectively. The failure ratio of the ethanol group was significantly lower (3% vs. 25%, respectively) than that of the hypertonic saline group (p = 0.014).

Bottom Line: Treatment success was determined six months later with follow-up clinical evaluation and performing ultrasonography.The complete regression ratio of the ethanol group was significantly higher (94% versus 72%, respectively) than that of the HS group.The failure ratio of the ethanol group was significantly lower (3% versus 25%, respectively) than that of the HS group.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Cumhuriyet University School of Medicine, Sivas, Turkey. hegilmez@cumhuriyet.edu.tr

ABSTRACT

Objective: We wanted to compare the efficacies of 95% ethanol and 20% hypertonic saline (HS) sclerotherapies that were performed in a single session under CT guidance for the management of simple renal cysts.

Materials and methods: A prospective series of 74 consecutive patients (average age: 57.6 +/- 8.1 years) with simple renal cysts were enrolled in this study. They were randomized into two groups and 95% ethanol or 20% HS, respectively, corresponding to 25% of the aspiration volume, was injected. Treatment success was determined six months later with follow-up clinical evaluation and performing ultrasonography.

Results: The sclerotherapy was accepted as technically successful without major complications in all except two patients who were excluded because of a communication between the simple renal cyst and the pelvicalyceal collecting system. Thirty-six patients in the ethanol group received sclerotherapy with 95% ethanol and 36 patients in the HS group underwent sclerotherapy with 20% HS. The complete regression ratio of the ethanol group was significantly higher (94% versus 72%, respectively) than that of the HS group. There was one patient with partial regression in each group. The failure ratio of the ethanol group was significantly lower (3% versus 25%, respectively) than that of the HS group.

Conclusion: Ethanol sclerotherapy under CT guidance is a successful and safe procedure and it can be used for the treatment of simple renal cysts. Sclerotherapy with 95% ethanol is more effective than 20% HS sclerotherapy. Sclerotherapy with HS may be an option for patients preferring to undergo a less painful treatment procedure.

Show MeSH
Related in: MedlinePlus