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Diffusion-weighted imaging with sensitivity encoding (SENSE) for detecting cranial bone marrow metastases: comparison with T1-weighted images.

Moon WJ, Lee MH, Chung EC - Korean J Radiol (2007 May-Jun)

Bottom Line: Quantitatively, B0 images (SD%, 82.1 +/- 7.9%) showed better lesion contrast than isotropic DWI (SD%, 71.4 +/- 13.7%) and T1WI (SD%, 65.7 +/- 9.3%) images.For scan times of less than 30 seconds, DWI with SENSE was able to detect bone marrow involvement, and was superior to T1WI in terms of lesion conspicuity.DWI with SENSE may be helpful for the detection of cranial bone/bone marrow metastases when used in conjunction with conventional MR sequences.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: This study was designed to determine whether diffusion-weighted imaging (DWI) with sensitivity encoding (SENSE) could detect bone marrow involvement in patients with cranial bone marrow (CBM) metastases. DWI results obtained were compared with T1-weighted imaging (T1WI) findings.

Materials and methods: DWI with sensitivity encoding (SENSE; b value = 1,000) was performed consecutively in 13 patients with CBM metastases diagnosed pathologically and radiologically. CBM lesions were dichotomized according to the involved site, i.e., skull base or calvarium. Two radiologists qualitatively evaluated the relative conspicuousness of CBM lesions and image qualities in B0 and in isotropic DWI and in T1WI. According to region of interest analysis of normal and pathologic marrow for these three sequences, absolute signal difference percentages (SD%) were calculated to quantitatively analyze lesion contrast.

Results: All 20 lesions in 13 patients with CBM metastases revealed abnormal DWI signals in areas corresponding to T1WI abnormalities. Both skull base and calvarial lesions provided better lesion conspicuousness than T1WI and B0 images. Although the image quality of DWI was less satisfactory than that of T1WI, relatively good image qualities were obtained. Quantitatively, B0 images (SD%, 82.1 +/- 7.9%) showed better lesion contrast than isotropic DWI (SD%, 71.4 +/- 13.7%) and T1WI (SD%, 65.7 +/- 9.3%) images.

Conclusion: For scan times of less than 30 seconds, DWI with SENSE was able to detect bone marrow involvement, and was superior to T1WI in terms of lesion conspicuity. DWI with SENSE may be helpful for the detection of cranial bone/bone marrow metastases when used in conjunction with conventional MR sequences.

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A 71-year-old woman with lung cancer (case no. 4). T1-weighted image (A), B0 image (B), isotropic diffusion-weighted image (C), and an apparent diffusion coefficient map (D) were obtained. Abnormalities in signal intensity due to bone marrow metastases (arrow) are evident on all images. However, the relative lesion conspicuousness is better on the B0 image and the isotropic diffusion-weighted image than on the T1-weighted image.
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Figure 1: A 71-year-old woman with lung cancer (case no. 4). T1-weighted image (A), B0 image (B), isotropic diffusion-weighted image (C), and an apparent diffusion coefficient map (D) were obtained. Abnormalities in signal intensity due to bone marrow metastases (arrow) are evident on all images. However, the relative lesion conspicuousness is better on the B0 image and the isotropic diffusion-weighted image than on the T1-weighted image.

Mentions: No abnormal lesions of the bone/bone marrow were observed by DWI and conventional sequences in the 13 healthy volunteers. However, a total of 20 lesions were found in the 13 patients (Table 1): nine lesions were located in the clivus and 11 in the calvarium. In all patients with cranial bone/bone marrow metastases, abnormal signal intensities were detected on DWI (B0 and isotropic image) areas corresponding to T1WI abnormalities (Fig. 1). In both the clival and calvarial regions, the relative conspicuousness of lesions by DWI tended to be better than that by T1WI. Compared with T1WI and B0 images, isotropic images showed more conspicuous lesions (Table 2). Although the image quality of DWI was less satisfactory than that of T1WI, DWI provided relatively good image quality (Table 3). Even in the clival region, the image qualities of the isotropic and B0 DWI were mainly good (n = 8, 88.9%) or excellent (n = 7, 77.8%) (Fig. 2).


Diffusion-weighted imaging with sensitivity encoding (SENSE) for detecting cranial bone marrow metastases: comparison with T1-weighted images.

Moon WJ, Lee MH, Chung EC - Korean J Radiol (2007 May-Jun)

A 71-year-old woman with lung cancer (case no. 4). T1-weighted image (A), B0 image (B), isotropic diffusion-weighted image (C), and an apparent diffusion coefficient map (D) were obtained. Abnormalities in signal intensity due to bone marrow metastases (arrow) are evident on all images. However, the relative lesion conspicuousness is better on the B0 image and the isotropic diffusion-weighted image than on the T1-weighted image.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627421&req=5

Figure 1: A 71-year-old woman with lung cancer (case no. 4). T1-weighted image (A), B0 image (B), isotropic diffusion-weighted image (C), and an apparent diffusion coefficient map (D) were obtained. Abnormalities in signal intensity due to bone marrow metastases (arrow) are evident on all images. However, the relative lesion conspicuousness is better on the B0 image and the isotropic diffusion-weighted image than on the T1-weighted image.
Mentions: No abnormal lesions of the bone/bone marrow were observed by DWI and conventional sequences in the 13 healthy volunteers. However, a total of 20 lesions were found in the 13 patients (Table 1): nine lesions were located in the clivus and 11 in the calvarium. In all patients with cranial bone/bone marrow metastases, abnormal signal intensities were detected on DWI (B0 and isotropic image) areas corresponding to T1WI abnormalities (Fig. 1). In both the clival and calvarial regions, the relative conspicuousness of lesions by DWI tended to be better than that by T1WI. Compared with T1WI and B0 images, isotropic images showed more conspicuous lesions (Table 2). Although the image quality of DWI was less satisfactory than that of T1WI, DWI provided relatively good image quality (Table 3). Even in the clival region, the image qualities of the isotropic and B0 DWI were mainly good (n = 8, 88.9%) or excellent (n = 7, 77.8%) (Fig. 2).

Bottom Line: Quantitatively, B0 images (SD%, 82.1 +/- 7.9%) showed better lesion contrast than isotropic DWI (SD%, 71.4 +/- 13.7%) and T1WI (SD%, 65.7 +/- 9.3%) images.For scan times of less than 30 seconds, DWI with SENSE was able to detect bone marrow involvement, and was superior to T1WI in terms of lesion conspicuity.DWI with SENSE may be helpful for the detection of cranial bone/bone marrow metastases when used in conjunction with conventional MR sequences.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Objective: This study was designed to determine whether diffusion-weighted imaging (DWI) with sensitivity encoding (SENSE) could detect bone marrow involvement in patients with cranial bone marrow (CBM) metastases. DWI results obtained were compared with T1-weighted imaging (T1WI) findings.

Materials and methods: DWI with sensitivity encoding (SENSE; b value = 1,000) was performed consecutively in 13 patients with CBM metastases diagnosed pathologically and radiologically. CBM lesions were dichotomized according to the involved site, i.e., skull base or calvarium. Two radiologists qualitatively evaluated the relative conspicuousness of CBM lesions and image qualities in B0 and in isotropic DWI and in T1WI. According to region of interest analysis of normal and pathologic marrow for these three sequences, absolute signal difference percentages (SD%) were calculated to quantitatively analyze lesion contrast.

Results: All 20 lesions in 13 patients with CBM metastases revealed abnormal DWI signals in areas corresponding to T1WI abnormalities. Both skull base and calvarial lesions provided better lesion conspicuousness than T1WI and B0 images. Although the image quality of DWI was less satisfactory than that of T1WI, relatively good image qualities were obtained. Quantitatively, B0 images (SD%, 82.1 +/- 7.9%) showed better lesion contrast than isotropic DWI (SD%, 71.4 +/- 13.7%) and T1WI (SD%, 65.7 +/- 9.3%) images.

Conclusion: For scan times of less than 30 seconds, DWI with SENSE was able to detect bone marrow involvement, and was superior to T1WI in terms of lesion conspicuity. DWI with SENSE may be helpful for the detection of cranial bone/bone marrow metastases when used in conjunction with conventional MR sequences.

Show MeSH
Related in: MedlinePlus