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Reproducibility of computer-aided detection marks in digital mammography.

Kim SJ, Moon WK, Cho N, Cha JH, Kim SM, Im JG - Korean J Radiol (2007 May-Jun)

Bottom Line: In 84 ipsilateral serial MLO image sets (two patients had bilateral cancers), identical images, regardless of the existence of CAD marks, were obtained for 35% (29/84) and identical images with CAD marks were obtained for 29% (23/78).Identical images, regardless of the existence of CAD marks, for contralateral MLO images were 65% (52/80) and identical images with CAD marks were obtained for 28% (11/39).Minute positional change and patient movement can alter the images and result in a significant effect on the algorithm utilized by the CAD for detecting microcalcifications.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Konkuk University Hospital, Seoul, Korea.

ABSTRACT

Objective: To evaluate the performance and reproducibility of a computeraided detection (CAD) system in mediolateral oblique (MLO) digital mammograms taken serially, without release of breast compression.

Materials and methods: A CAD system was applied preoperatively to the fullfield digital mammograms of two MLO views taken without release of breast compression in 82 patients (age range: 33-83 years; mean age: 49 years) with previously diagnosed breast cancers. The total number of visible lesion components in 82 patients was 101: 66 masses and 35 microcalcifications. We analyzed the sensitivity and reproducibility of the CAD marks.

Results: The sensitivity of the CAD system for first MLO views was 71% (47/66) for masses and 80% (28/35) for microcalcifications. The sensitivity of the CAD system for second MLO views was 68% (45/66) for masses and 17% (6/35) for microcalcifications. In 84 ipsilateral serial MLO image sets (two patients had bilateral cancers), identical images, regardless of the existence of CAD marks, were obtained for 35% (29/84) and identical images with CAD marks were obtained for 29% (23/78). Identical images, regardless of the existence of CAD marks, for contralateral MLO images were 65% (52/80) and identical images with CAD marks were obtained for 28% (11/39). The reproducibility of CAD marks for the true positive masses in serial MLO views was 84% (42/50) and that for the true positive microcalcifications was 0% (0/34).

Conclusion: The CAD system in digital mammograms showed a high sensitivity for detecting masses and microcalcifications. However, reproducibility of microcalcification marks was very low in MLO views taken serially without release of breast compression. Minute positional change and patient movement can alter the images and result in a significant effect on the algorithm utilized by the CAD for detecting microcalcifications.

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Related in: MedlinePlus

A 61-year-old woman presented with a screening-detected breast cancer in the left breast.A,B. Serial mediolateral oblique digital mammograms taken without release of breast compression within 19 seconds. The computer-aided detection system marks the mass component and the microcalcifications component correctly on the first mediolateral oblique view (A) (asterisk and triangle). The computer-aided detection system, however, does not mark the microcalcifications on the second mediolateral oblique view (B).
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Figure 3: A 61-year-old woman presented with a screening-detected breast cancer in the left breast.A,B. Serial mediolateral oblique digital mammograms taken without release of breast compression within 19 seconds. The computer-aided detection system marks the mass component and the microcalcifications component correctly on the first mediolateral oblique view (A) (asterisk and triangle). The computer-aided detection system, however, does not mark the microcalcifications on the second mediolateral oblique view (B).

Mentions: The mark-based reproducibility for true positive mass marks in the serial MLO views was 84% (42 of 50) and that for true positive microcalcification marks was 0% (0 of 34) (Table 3) (Figs. 1, 2). The 28 calcific clusters that were correctly marked on the first MLO views were not marked on the second MLO views, while six calcific clusters that were correctly marked on the second MLO views were not marked on the first MLO views. The reproducibility for true positive mass marks was significantly higher in the fatty breast group than in the dense breast group (100% vs. 68%, p = 0.0015) (Fig. 3). For ipsilateral breasts, the reproducibility for false positive mass marks was 42% (8 of 19) and that for false positive microcalcification marks was 0% (0 of 19) (Fig. 1). For contralateral breasts, the reproducibility for false positive mass marks was 44% (16 of 36) and that for false positive microcalcification marks was 0% (0 of 18) (Fig. 1). In total, for bilateral breasts, the reproducibility for false positive mass marks was 44% (24 of 55) and that for false positive microcalcification marks was 0% (0 of 37). The reproducibility for false positive mass marks in bilateral breasts was slightly higher in the fatty breast group than in the dense breast group, but that difference was not found to be statistically significant (48% [12 of 25] vs. 40% [12 of 30], p = 0.5).


Reproducibility of computer-aided detection marks in digital mammography.

Kim SJ, Moon WK, Cho N, Cha JH, Kim SM, Im JG - Korean J Radiol (2007 May-Jun)

A 61-year-old woman presented with a screening-detected breast cancer in the left breast.A,B. Serial mediolateral oblique digital mammograms taken without release of breast compression within 19 seconds. The computer-aided detection system marks the mass component and the microcalcifications component correctly on the first mediolateral oblique view (A) (asterisk and triangle). The computer-aided detection system, however, does not mark the microcalcifications on the second mediolateral oblique view (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627414&req=5

Figure 3: A 61-year-old woman presented with a screening-detected breast cancer in the left breast.A,B. Serial mediolateral oblique digital mammograms taken without release of breast compression within 19 seconds. The computer-aided detection system marks the mass component and the microcalcifications component correctly on the first mediolateral oblique view (A) (asterisk and triangle). The computer-aided detection system, however, does not mark the microcalcifications on the second mediolateral oblique view (B).
Mentions: The mark-based reproducibility for true positive mass marks in the serial MLO views was 84% (42 of 50) and that for true positive microcalcification marks was 0% (0 of 34) (Table 3) (Figs. 1, 2). The 28 calcific clusters that were correctly marked on the first MLO views were not marked on the second MLO views, while six calcific clusters that were correctly marked on the second MLO views were not marked on the first MLO views. The reproducibility for true positive mass marks was significantly higher in the fatty breast group than in the dense breast group (100% vs. 68%, p = 0.0015) (Fig. 3). For ipsilateral breasts, the reproducibility for false positive mass marks was 42% (8 of 19) and that for false positive microcalcification marks was 0% (0 of 19) (Fig. 1). For contralateral breasts, the reproducibility for false positive mass marks was 44% (16 of 36) and that for false positive microcalcification marks was 0% (0 of 18) (Fig. 1). In total, for bilateral breasts, the reproducibility for false positive mass marks was 44% (24 of 55) and that for false positive microcalcification marks was 0% (0 of 37). The reproducibility for false positive mass marks in bilateral breasts was slightly higher in the fatty breast group than in the dense breast group, but that difference was not found to be statistically significant (48% [12 of 25] vs. 40% [12 of 30], p = 0.5).

Bottom Line: In 84 ipsilateral serial MLO image sets (two patients had bilateral cancers), identical images, regardless of the existence of CAD marks, were obtained for 35% (29/84) and identical images with CAD marks were obtained for 29% (23/78).Identical images, regardless of the existence of CAD marks, for contralateral MLO images were 65% (52/80) and identical images with CAD marks were obtained for 28% (11/39).Minute positional change and patient movement can alter the images and result in a significant effect on the algorithm utilized by the CAD for detecting microcalcifications.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Konkuk University Hospital, Seoul, Korea.

ABSTRACT

Objective: To evaluate the performance and reproducibility of a computeraided detection (CAD) system in mediolateral oblique (MLO) digital mammograms taken serially, without release of breast compression.

Materials and methods: A CAD system was applied preoperatively to the fullfield digital mammograms of two MLO views taken without release of breast compression in 82 patients (age range: 33-83 years; mean age: 49 years) with previously diagnosed breast cancers. The total number of visible lesion components in 82 patients was 101: 66 masses and 35 microcalcifications. We analyzed the sensitivity and reproducibility of the CAD marks.

Results: The sensitivity of the CAD system for first MLO views was 71% (47/66) for masses and 80% (28/35) for microcalcifications. The sensitivity of the CAD system for second MLO views was 68% (45/66) for masses and 17% (6/35) for microcalcifications. In 84 ipsilateral serial MLO image sets (two patients had bilateral cancers), identical images, regardless of the existence of CAD marks, were obtained for 35% (29/84) and identical images with CAD marks were obtained for 29% (23/78). Identical images, regardless of the existence of CAD marks, for contralateral MLO images were 65% (52/80) and identical images with CAD marks were obtained for 28% (11/39). The reproducibility of CAD marks for the true positive masses in serial MLO views was 84% (42/50) and that for the true positive microcalcifications was 0% (0/34).

Conclusion: The CAD system in digital mammograms showed a high sensitivity for detecting masses and microcalcifications. However, reproducibility of microcalcification marks was very low in MLO views taken serially without release of breast compression. Minute positional change and patient movement can alter the images and result in a significant effect on the algorithm utilized by the CAD for detecting microcalcifications.

Show MeSH
Related in: MedlinePlus