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Extramedullary plasmacytoma involving the bilateral adrenal glands on MR imaging.

Li Y, Guo YK, Yang ZG, Ma ES, Min PQ - Korean J Radiol (2007 May-Jun)

Bottom Line: We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands.This case is of interest in that the bilateral adrenals were involved.In this article, we present the MRI findings and we briefly review the relevant literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, West China Hospital, Sichuan University, Sichuan, China.

ABSTRACT
We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands. Primary adrenal extramedullary plasmacytoma is extremely rare and only three cases of extramedullary plasmacytoma in the unilateral adrenal gland have currently been reported on. This case is of interest in that the bilateral adrenals were involved. In this article, we present the MRI findings and we briefly review the relevant literature.

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A. Photomicrography of the histology specimen shows the tumor consists of poorly-differentiated plasma cells with large and hyperchromatic nuclei (Haematoxylin & Eosin, × 300).B. Immunohistochemical staining of the resected masses is positive for the monoclonality of IgG-lambda (Immunohistochemical staining, × 200).
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Figure 2: A. Photomicrography of the histology specimen shows the tumor consists of poorly-differentiated plasma cells with large and hyperchromatic nuclei (Haematoxylin & Eosin, × 300).B. Immunohistochemical staining of the resected masses is positive for the monoclonality of IgG-lambda (Immunohistochemical staining, × 200).

Mentions: Surgical excision of the masses was recommended because malignant lesion was suspected due to the right adrenal mass invading the inferior vena cava and the upper polar of the right kidney on the MR images. After laparotomy, it was revealed that the right mass infiltrated the inferior vena cava and the upper polar of the right kidney, so right adrenalectomy was performed. The mass on the left adrenal region was removed simultaneously. The surgically excised masses were solid without any presence of hemorrhage and necrosis. Light microscopy revealed that the masses were composed of poorly-differentiated plasma cells and cells with multiple nuclei (Fig. 2A). The immunohistochemical staining was positive for monoclonality of IgG-lambda (Fig. 2B), but it was negative for kappa light chain. Based on these findings, the masses were diagnosed as extramedullary plasmacytoma arising from the bilateral adrenal glands.


Extramedullary plasmacytoma involving the bilateral adrenal glands on MR imaging.

Li Y, Guo YK, Yang ZG, Ma ES, Min PQ - Korean J Radiol (2007 May-Jun)

A. Photomicrography of the histology specimen shows the tumor consists of poorly-differentiated plasma cells with large and hyperchromatic nuclei (Haematoxylin & Eosin, × 300).B. Immunohistochemical staining of the resected masses is positive for the monoclonality of IgG-lambda (Immunohistochemical staining, × 200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627410&req=5

Figure 2: A. Photomicrography of the histology specimen shows the tumor consists of poorly-differentiated plasma cells with large and hyperchromatic nuclei (Haematoxylin & Eosin, × 300).B. Immunohistochemical staining of the resected masses is positive for the monoclonality of IgG-lambda (Immunohistochemical staining, × 200).
Mentions: Surgical excision of the masses was recommended because malignant lesion was suspected due to the right adrenal mass invading the inferior vena cava and the upper polar of the right kidney on the MR images. After laparotomy, it was revealed that the right mass infiltrated the inferior vena cava and the upper polar of the right kidney, so right adrenalectomy was performed. The mass on the left adrenal region was removed simultaneously. The surgically excised masses were solid without any presence of hemorrhage and necrosis. Light microscopy revealed that the masses were composed of poorly-differentiated plasma cells and cells with multiple nuclei (Fig. 2A). The immunohistochemical staining was positive for monoclonality of IgG-lambda (Fig. 2B), but it was negative for kappa light chain. Based on these findings, the masses were diagnosed as extramedullary plasmacytoma arising from the bilateral adrenal glands.

Bottom Line: We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands.This case is of interest in that the bilateral adrenals were involved.In this article, we present the MRI findings and we briefly review the relevant literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, West China Hospital, Sichuan University, Sichuan, China.

ABSTRACT
We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands. Primary adrenal extramedullary plasmacytoma is extremely rare and only three cases of extramedullary plasmacytoma in the unilateral adrenal gland have currently been reported on. This case is of interest in that the bilateral adrenals were involved. In this article, we present the MRI findings and we briefly review the relevant literature.

Show MeSH
Related in: MedlinePlus