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High-intensity focused ultrasound therapy: an overview for radiologists.

Kim YS, Rhim H, Choi MJ, Lim HK, Choi D - Korean J Radiol (2008 Jul-Aug)

Bottom Line: This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery.However, the application of this technology still has many drawbacks.It is expected that current obstacles to implementation will be resolved in the near future.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments.

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Related in: MedlinePlus

Basic concept of HIFU-induced tissue change by hyperthermia. As US waves are focused onto small spot, acoustic pressure is rapidly elevated near focus where tissue temperatures are also raised to level that is sufficient for thermotherapeutic effects, resulting in coagulation necrosis.
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Figure 2: Basic concept of HIFU-induced tissue change by hyperthermia. As US waves are focused onto small spot, acoustic pressure is rapidly elevated near focus where tissue temperatures are also raised to level that is sufficient for thermotherapeutic effects, resulting in coagulation necrosis.

Mentions: While other minimally invasive therapies such as radiofrequency ablation or microwave ablation use an electrode or antenna to deliver electromagnetic waves, HIFU therapy makes use of US waves as carriers of energy, which is propagated through human tissues. US has been shown to have no detrimental effect on the human body within the diagnostic ranges used (8, 9). However, it must be noted that US waves carry energy that causes biological reactions in various ways (discussed later) although these are usually minimal. The main challenge of this technique is to maximize energy-accumulation at the target area in order to induce significant biological reactions without causing harm to the intervening tissues such as the skin and the tissues surrounding the target area. HIFU therapy has adopted two strategies to resolve this problem. It uses high energy US waves generated from numerous sources and focuses them to a small spot (Fig. 2).


High-intensity focused ultrasound therapy: an overview for radiologists.

Kim YS, Rhim H, Choi MJ, Lim HK, Choi D - Korean J Radiol (2008 Jul-Aug)

Basic concept of HIFU-induced tissue change by hyperthermia. As US waves are focused onto small spot, acoustic pressure is rapidly elevated near focus where tissue temperatures are also raised to level that is sufficient for thermotherapeutic effects, resulting in coagulation necrosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627265&req=5

Figure 2: Basic concept of HIFU-induced tissue change by hyperthermia. As US waves are focused onto small spot, acoustic pressure is rapidly elevated near focus where tissue temperatures are also raised to level that is sufficient for thermotherapeutic effects, resulting in coagulation necrosis.
Mentions: While other minimally invasive therapies such as radiofrequency ablation or microwave ablation use an electrode or antenna to deliver electromagnetic waves, HIFU therapy makes use of US waves as carriers of energy, which is propagated through human tissues. US has been shown to have no detrimental effect on the human body within the diagnostic ranges used (8, 9). However, it must be noted that US waves carry energy that causes biological reactions in various ways (discussed later) although these are usually minimal. The main challenge of this technique is to maximize energy-accumulation at the target area in order to induce significant biological reactions without causing harm to the intervening tissues such as the skin and the tissues surrounding the target area. HIFU therapy has adopted two strategies to resolve this problem. It uses high energy US waves generated from numerous sources and focuses them to a small spot (Fig. 2).

Bottom Line: This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery.However, the application of this technology still has many drawbacks.It is expected that current obstacles to implementation will be resolved in the near future.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments.

Show MeSH
Related in: MedlinePlus