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Solitary pulmonary nodule on helical dynamic CT scans: analysis of the enhancement patterns using a computer-aided diagnosis (CAD) system.

Choi EJ, Jin GY, Han YM, Lee YS, Kweon KS - Korean J Radiol (2008 Sep-Oct)

Bottom Line: On the Bland and Altman plot, the net enhancement difference between the CAD system and direct personal drawing was not significant (within +/- 2 standard deriation).The sensitivity, specificity, PPV, NPV and accuracy of diagnosing malignant SPNs using direct drawing was 92%, 89%, 79%, 92% and 88%, respectively.The CAD system was a useful tool for diagnosing malignant SPNs.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Chonbuk National University Hospital and Medical School, Research Institute for Medical Science, Chonbuk, Korea.

ABSTRACT

Objective: We wanted to investigate the usefulness of a computer-aided diagnosis (CAD) system in assisting radiologists to diagnosis malignant solitary pulmonary nodules (SPNs), as compared with diagnosing SPNs with using direct personal drawing.

Materials and methods: Forty patients with SPNs were analyzed. After the pre-contrast scan was performed, an additional ten series of post-contrast images were obtained at 20-second intervals. Two investigators measured the attenuation values of the SPNs: a radiologist who drew the regions of interest (ROIs), and a technician who used a CAD system. The Bland and Altman plots were used to compare the net enhancement between a CAD system and direct personal drawing. The diagnostic characteristics of the malignant SPNs were calculated by considering the CAD and direct personal drawing and with using Fisher's exact test.

Results: On the Bland and Altman plot, the net enhancement difference between the CAD system and direct personal drawing was not significant (within +/- 2 standard deriation). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of diagnosing malignant SPNs using CAD was 92%, 85%, 75%, 96% and 88%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of diagnosing malignant SPNs using direct drawing was 92%, 89%, 79%, 92% and 88%, respectively.

Conclusion: The CAD system was a useful tool for diagnosing malignant SPNs.

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Related in: MedlinePlus

CT scan of adenocarcinoma with enhancement (≥15 HU wash-in, 5-25 HU washout) in 72-year-old man. Time attenuation curve obtained through nodule for 5 minutes showed similar enhancement patterns of CAD system (short line) and direct personal drawing (long line).
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Figure 4: CT scan of adenocarcinoma with enhancement (≥15 HU wash-in, 5-25 HU washout) in 72-year-old man. Time attenuation curve obtained through nodule for 5 minutes showed similar enhancement patterns of CAD system (short line) and direct personal drawing (long line).

Mentions: On the other hand, of the 27 benign nodules, the CAD system and direct personal drawing of 25 nodules (92.6%) showed a similar TAC (Fig. 3). Of the 13 malignant nodules, the CAD system and direct personal drawing of 10 nodules (83.3%) showed a similar TAC (Fig. 4). The sensitivity, specificity, PPV, NPV and accuracy obtained by the TAC of the malignant SPNs and using CAD was 92% (12/13), 85% (23/27), 75% (12/16), 96% (23/24) and 88% (35/40), respectively. The sensitivity, specificity, PPV, NPV and accuracy obtained by the TAC of the malignant SPNs and using direct drawing was 92% (12/13), 89% (24/27), 79% (14/16), 92% (24/26) and 88% (35/40), respectively.


Solitary pulmonary nodule on helical dynamic CT scans: analysis of the enhancement patterns using a computer-aided diagnosis (CAD) system.

Choi EJ, Jin GY, Han YM, Lee YS, Kweon KS - Korean J Radiol (2008 Sep-Oct)

CT scan of adenocarcinoma with enhancement (≥15 HU wash-in, 5-25 HU washout) in 72-year-old man. Time attenuation curve obtained through nodule for 5 minutes showed similar enhancement patterns of CAD system (short line) and direct personal drawing (long line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627214&req=5

Figure 4: CT scan of adenocarcinoma with enhancement (≥15 HU wash-in, 5-25 HU washout) in 72-year-old man. Time attenuation curve obtained through nodule for 5 minutes showed similar enhancement patterns of CAD system (short line) and direct personal drawing (long line).
Mentions: On the other hand, of the 27 benign nodules, the CAD system and direct personal drawing of 25 nodules (92.6%) showed a similar TAC (Fig. 3). Of the 13 malignant nodules, the CAD system and direct personal drawing of 10 nodules (83.3%) showed a similar TAC (Fig. 4). The sensitivity, specificity, PPV, NPV and accuracy obtained by the TAC of the malignant SPNs and using CAD was 92% (12/13), 85% (23/27), 75% (12/16), 96% (23/24) and 88% (35/40), respectively. The sensitivity, specificity, PPV, NPV and accuracy obtained by the TAC of the malignant SPNs and using direct drawing was 92% (12/13), 89% (24/27), 79% (14/16), 92% (24/26) and 88% (35/40), respectively.

Bottom Line: On the Bland and Altman plot, the net enhancement difference between the CAD system and direct personal drawing was not significant (within +/- 2 standard deriation).The sensitivity, specificity, PPV, NPV and accuracy of diagnosing malignant SPNs using direct drawing was 92%, 89%, 79%, 92% and 88%, respectively.The CAD system was a useful tool for diagnosing malignant SPNs.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Chonbuk National University Hospital and Medical School, Research Institute for Medical Science, Chonbuk, Korea.

ABSTRACT

Objective: We wanted to investigate the usefulness of a computer-aided diagnosis (CAD) system in assisting radiologists to diagnosis malignant solitary pulmonary nodules (SPNs), as compared with diagnosing SPNs with using direct personal drawing.

Materials and methods: Forty patients with SPNs were analyzed. After the pre-contrast scan was performed, an additional ten series of post-contrast images were obtained at 20-second intervals. Two investigators measured the attenuation values of the SPNs: a radiologist who drew the regions of interest (ROIs), and a technician who used a CAD system. The Bland and Altman plots were used to compare the net enhancement between a CAD system and direct personal drawing. The diagnostic characteristics of the malignant SPNs were calculated by considering the CAD and direct personal drawing and with using Fisher's exact test.

Results: On the Bland and Altman plot, the net enhancement difference between the CAD system and direct personal drawing was not significant (within +/- 2 standard deriation). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of diagnosing malignant SPNs using CAD was 92%, 85%, 75%, 96% and 88%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of diagnosing malignant SPNs using direct drawing was 92%, 89%, 79%, 92% and 88%, respectively.

Conclusion: The CAD system was a useful tool for diagnosing malignant SPNs.

Show MeSH
Related in: MedlinePlus