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Gastrointestinal complications following hematopoietic stem cell transplantation in children.

Lee JH, Lim GY, Im SA, Chung NG, Hahn ST - Korean J Radiol (2008 Sep-Oct)

Bottom Line: Gastrointestinal system involvement is one of the principal complications seen in the recipients of hematopoietic stem cell transplantation (HSCT), and it is also a major cause of morbidity and death in these patients.The major gastrointestinal complications include typhlitis (neutropenic enterocolitis), pseudomembranous enterocolitis, viral enteritis, graft-versus-host disease, benign pneumatosis intestinalis, intestinal thrombotic microangiopathy, and post-transplantation lymphoproliferative disease.As these patients present with nonspecific abdominal symptoms, evaluation with using such imaging modalities as ultrasonography and CT is essential in order to assess the extent of gastrointestinal involvement and to diagnose these complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

ABSTRACT
Gastrointestinal system involvement is one of the principal complications seen in the recipients of hematopoietic stem cell transplantation (HSCT), and it is also a major cause of morbidity and death in these patients. The major gastrointestinal complications include typhlitis (neutropenic enterocolitis), pseudomembranous enterocolitis, viral enteritis, graft-versus-host disease, benign pneumatosis intestinalis, intestinal thrombotic microangiopathy, and post-transplantation lymphoproliferative disease. As these patients present with nonspecific abdominal symptoms, evaluation with using such imaging modalities as ultrasonography and CT is essential in order to assess the extent of gastrointestinal involvement and to diagnose these complications. We present here a pictorial review of the imaging features and other factors involved in the diagnosis of these gastrointestinal complications in pediatric HSCT recipients.

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Related in: MedlinePlus

Post-transplantation lymphoproliferative disease involving small bowel in five-year-old boy, and this developed during third year following bench mark test for treating his leukemia.A. Longitudinal US of left mild abdomen shows short area of segmental severe concentric hypoechoic mural thickening (*), and this causes luminal narrowing in jejunum.B. CT scan shows short area of segmental concentric wall thickening with homogenous enhancement of small bowel loop in left side of abdomen (arrow).
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Figure 9: Post-transplantation lymphoproliferative disease involving small bowel in five-year-old boy, and this developed during third year following bench mark test for treating his leukemia.A. Longitudinal US of left mild abdomen shows short area of segmental severe concentric hypoechoic mural thickening (*), and this causes luminal narrowing in jejunum.B. CT scan shows short area of segmental concentric wall thickening with homogenous enhancement of small bowel loop in left side of abdomen (arrow).

Mentions: The imaging features of PTLD are similar those of non-Hodgkin's lymphoma. PTLD involving the GI tract may be infiltrative, and so it causes circumferential mural infiltration with luminal excavation or there is a discrete eccentric mass that causes luminal narrowing with intussusception (12) (Fig. 9).


Gastrointestinal complications following hematopoietic stem cell transplantation in children.

Lee JH, Lim GY, Im SA, Chung NG, Hahn ST - Korean J Radiol (2008 Sep-Oct)

Post-transplantation lymphoproliferative disease involving small bowel in five-year-old boy, and this developed during third year following bench mark test for treating his leukemia.A. Longitudinal US of left mild abdomen shows short area of segmental severe concentric hypoechoic mural thickening (*), and this causes luminal narrowing in jejunum.B. CT scan shows short area of segmental concentric wall thickening with homogenous enhancement of small bowel loop in left side of abdomen (arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627203&req=5

Figure 9: Post-transplantation lymphoproliferative disease involving small bowel in five-year-old boy, and this developed during third year following bench mark test for treating his leukemia.A. Longitudinal US of left mild abdomen shows short area of segmental severe concentric hypoechoic mural thickening (*), and this causes luminal narrowing in jejunum.B. CT scan shows short area of segmental concentric wall thickening with homogenous enhancement of small bowel loop in left side of abdomen (arrow).
Mentions: The imaging features of PTLD are similar those of non-Hodgkin's lymphoma. PTLD involving the GI tract may be infiltrative, and so it causes circumferential mural infiltration with luminal excavation or there is a discrete eccentric mass that causes luminal narrowing with intussusception (12) (Fig. 9).

Bottom Line: Gastrointestinal system involvement is one of the principal complications seen in the recipients of hematopoietic stem cell transplantation (HSCT), and it is also a major cause of morbidity and death in these patients.The major gastrointestinal complications include typhlitis (neutropenic enterocolitis), pseudomembranous enterocolitis, viral enteritis, graft-versus-host disease, benign pneumatosis intestinalis, intestinal thrombotic microangiopathy, and post-transplantation lymphoproliferative disease.As these patients present with nonspecific abdominal symptoms, evaluation with using such imaging modalities as ultrasonography and CT is essential in order to assess the extent of gastrointestinal involvement and to diagnose these complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

ABSTRACT
Gastrointestinal system involvement is one of the principal complications seen in the recipients of hematopoietic stem cell transplantation (HSCT), and it is also a major cause of morbidity and death in these patients. The major gastrointestinal complications include typhlitis (neutropenic enterocolitis), pseudomembranous enterocolitis, viral enteritis, graft-versus-host disease, benign pneumatosis intestinalis, intestinal thrombotic microangiopathy, and post-transplantation lymphoproliferative disease. As these patients present with nonspecific abdominal symptoms, evaluation with using such imaging modalities as ultrasonography and CT is essential in order to assess the extent of gastrointestinal involvement and to diagnose these complications. We present here a pictorial review of the imaging features and other factors involved in the diagnosis of these gastrointestinal complications in pediatric HSCT recipients.

Show MeSH
Related in: MedlinePlus