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Metastatic thymoma of the breast.

Kim SM, Ko EY, Han BK, Shin JH, Kang SS, Nam SJ, Cho EY - Korean J Radiol (2008 Jan-Feb)

Bottom Line: Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors.She presented with a palpable mass in her left breast.Mammography and ultrasonogram showed a lobular mass at the anterior glandular portion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-Gu, Seoul, Korea.

ABSTRACT
Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors. Distant metastasis of thymoma is very rare, and especially to extrathorcic areas. We report a female who had a metastatic thymoma in her breast 20 years after undergoing resection for a non-invasive thymoma. She presented with a palpable mass in her left breast. Mammography and ultrasonogram showed a lobular mass at the anterior glandular portion. Histological examination after surgical excision revealed a metastatic thymoma.

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Photomicrograph (A) discloses lobular growth of the oval to polygonal cells that are separated by dense fibrous stroma (Hematoxylin & Eosin staining, ×100). Immunohistochemical staining (B) demonstrates the presence of thymocytes in the tumor cell nests (CD99, ×100).
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Figure 3: Photomicrograph (A) discloses lobular growth of the oval to polygonal cells that are separated by dense fibrous stroma (Hematoxylin & Eosin staining, ×100). Immunohistochemical staining (B) demonstrates the presence of thymocytes in the tumor cell nests (CD99, ×100).

Mentions: Mammography showed a high-density mass, 2.3 cm, with irregular shaped in the left upper outer breast (Fig. 1). On ultrasound (US), a hypoechoic mass, 2.6 cm, with irregular shaped was noted in the junction of the breast parenchyma and the subcutaneous fat layer (Fig. 2A). Color Doppler US showed increased vascularity within the mass (Fig. 2B). US-guided core needle biopsy and surgical excision showed a metastatic thymoma of the B3 type. On microscopic examination, the tumor was predominantly composed of solid nests of oval or polygonal epithelial cells separated by dense fibrous septa. The nests were admixed with a minor component of lymphocytes, resulting in a lobular sheet-like growth of the neoplastic epithelial cells (Fig. 3A). On immunohistochemistry staining, the tumor cells were positive for CK (AE1/AE3) and CD99, and TdT-positive thymocytes were found in the tumor cell nests (Fig. 3B).


Metastatic thymoma of the breast.

Kim SM, Ko EY, Han BK, Shin JH, Kang SS, Nam SJ, Cho EY - Korean J Radiol (2008 Jan-Feb)

Photomicrograph (A) discloses lobular growth of the oval to polygonal cells that are separated by dense fibrous stroma (Hematoxylin & Eosin staining, ×100). Immunohistochemical staining (B) demonstrates the presence of thymocytes in the tumor cell nests (CD99, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2627170&req=5

Figure 3: Photomicrograph (A) discloses lobular growth of the oval to polygonal cells that are separated by dense fibrous stroma (Hematoxylin & Eosin staining, ×100). Immunohistochemical staining (B) demonstrates the presence of thymocytes in the tumor cell nests (CD99, ×100).
Mentions: Mammography showed a high-density mass, 2.3 cm, with irregular shaped in the left upper outer breast (Fig. 1). On ultrasound (US), a hypoechoic mass, 2.6 cm, with irregular shaped was noted in the junction of the breast parenchyma and the subcutaneous fat layer (Fig. 2A). Color Doppler US showed increased vascularity within the mass (Fig. 2B). US-guided core needle biopsy and surgical excision showed a metastatic thymoma of the B3 type. On microscopic examination, the tumor was predominantly composed of solid nests of oval or polygonal epithelial cells separated by dense fibrous septa. The nests were admixed with a minor component of lymphocytes, resulting in a lobular sheet-like growth of the neoplastic epithelial cells (Fig. 3A). On immunohistochemistry staining, the tumor cells were positive for CK (AE1/AE3) and CD99, and TdT-positive thymocytes were found in the tumor cell nests (Fig. 3B).

Bottom Line: Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors.She presented with a palpable mass in her left breast.Mammography and ultrasonogram showed a lobular mass at the anterior glandular portion.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-Gu, Seoul, Korea.

ABSTRACT
Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors. Distant metastasis of thymoma is very rare, and especially to extrathorcic areas. We report a female who had a metastatic thymoma in her breast 20 years after undergoing resection for a non-invasive thymoma. She presented with a palpable mass in her left breast. Mammography and ultrasonogram showed a lobular mass at the anterior glandular portion. Histological examination after surgical excision revealed a metastatic thymoma.

Show MeSH
Related in: MedlinePlus