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EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells.

Gobin AM, Moon JJ, West JL - Int J Nanomedicine (2008)

Bottom Line: In this work, we sought to improve their specificity by targeting them to prostate tumor cells.We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells.We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.

ABSTRACT
Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.

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Related in: MedlinePlus

Spectra of nanoshells before and after surface conjugation of EphrinAl or PEG. There is minimal shift in the peak after conjugation, indicating that the nanoshells will be effective at absorbing the NIR light from the laser with minimal reduction in efficiency.
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f2-ijn-3-351: Spectra of nanoshells before and after surface conjugation of EphrinAl or PEG. There is minimal shift in the peak after conjugation, indicating that the nanoshells will be effective at absorbing the NIR light from the laser with minimal reduction in efficiency.

Mentions: Nanoshells were designed to have peak absorption in the near infrared. Nanoshells were made to be 142 nm in diameter with a 12 nm thick shell and had peak absorption at 800 nm. There was minimal spectral shift of only ~5.0 nm of the peak at 780 nm after EphrinAl or PEG conjugation to nanoshells (Figure 2). This demonstrates negligible effect of biomolecule conjugation on the optical properties of the nanoshells.


EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells.

Gobin AM, Moon JJ, West JL - Int J Nanomedicine (2008)

Spectra of nanoshells before and after surface conjugation of EphrinAl or PEG. There is minimal shift in the peak after conjugation, indicating that the nanoshells will be effective at absorbing the NIR light from the laser with minimal reduction in efficiency.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2626934&req=5

f2-ijn-3-351: Spectra of nanoshells before and after surface conjugation of EphrinAl or PEG. There is minimal shift in the peak after conjugation, indicating that the nanoshells will be effective at absorbing the NIR light from the laser with minimal reduction in efficiency.
Mentions: Nanoshells were designed to have peak absorption in the near infrared. Nanoshells were made to be 142 nm in diameter with a 12 nm thick shell and had peak absorption at 800 nm. There was minimal spectral shift of only ~5.0 nm of the peak at 780 nm after EphrinAl or PEG conjugation to nanoshells (Figure 2). This demonstrates negligible effect of biomolecule conjugation on the optical properties of the nanoshells.

Bottom Line: In this work, we sought to improve their specificity by targeting them to prostate tumor cells.We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells.We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA.

ABSTRACT
Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.

Show MeSH
Related in: MedlinePlus