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Nanocrystal technology, drug delivery and clinical applications.

Junghanns JU, Müller RH - Int J Nanomedicine (2008)

Bottom Line: The drug nanocrystals do not belong to the future; the first products are already on the market.The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product.Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, Berlin, Germany. juj@junghanns.net

ABSTRACT
Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. The drug nanocrystals do not belong to the future; the first products are already on the market. The industrially relevant production technologies, pearl milling and high pressure homogenization, are reviewed. The physics behind the drug nanocrystals and changes of their physical properties are discussed. The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product. Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

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Scanning electron microscopic picture of a nanosuspension prepared with high pressure homogenization.Used with permission from Möschwitzer (2005).
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f6-ijn-3-295: Scanning electron microscopic picture of a nanosuspension prepared with high pressure homogenization.Used with permission from Möschwitzer (2005).

Mentions: Of course, the use of water can have disadvantages, eg, hydrolysis of water-sensitive drugs and problems during subsequent drying steps (such as the removal of too much water). When applied to drugs with a low melting point, the drying process may quire expensive techniques like lyophilization. Therefore the technology is most suitable for the formulation of aqueous suspensions of nanocrystals (Figure 6) (Müller et al 2003).


Nanocrystal technology, drug delivery and clinical applications.

Junghanns JU, Müller RH - Int J Nanomedicine (2008)

Scanning electron microscopic picture of a nanosuspension prepared with high pressure homogenization.Used with permission from Möschwitzer (2005).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2626933&req=5

f6-ijn-3-295: Scanning electron microscopic picture of a nanosuspension prepared with high pressure homogenization.Used with permission from Möschwitzer (2005).
Mentions: Of course, the use of water can have disadvantages, eg, hydrolysis of water-sensitive drugs and problems during subsequent drying steps (such as the removal of too much water). When applied to drugs with a low melting point, the drying process may quire expensive techniques like lyophilization. Therefore the technology is most suitable for the formulation of aqueous suspensions of nanocrystals (Figure 6) (Müller et al 2003).

Bottom Line: The drug nanocrystals do not belong to the future; the first products are already on the market.The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product.Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, Berlin, Germany. juj@junghanns.net

ABSTRACT
Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. The drug nanocrystals do not belong to the future; the first products are already on the market. The industrially relevant production technologies, pearl milling and high pressure homogenization, are reviewed. The physics behind the drug nanocrystals and changes of their physical properties are discussed. The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product. Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

Show MeSH