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Nanocrystal technology, drug delivery and clinical applications.

Junghanns JU, Müller RH - Int J Nanomedicine (2008)

Bottom Line: The drug nanocrystals do not belong to the future; the first products are already on the market.The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product.Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, Berlin, Germany. juj@junghanns.net

ABSTRACT
Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. The drug nanocrystals do not belong to the future; the first products are already on the market. The industrially relevant production technologies, pearl milling and high pressure homogenization, are reviewed. The physics behind the drug nanocrystals and changes of their physical properties are discussed. The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product. Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

Show MeSH
Increasing dissolution pressure over a flat surface, a microparticle, and a nanoparticle.Abbreviations: p, dissolution pressure; a, flat surface; b, microparticle; c, nanoparticle. Used with permission from Junghanns (2006).
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f3-ijn-3-295: Increasing dissolution pressure over a flat surface, a microparticle, and a nanoparticle.Abbreviations: p, dissolution pressure; a, flat surface; b, microparticle; c, nanoparticle. Used with permission from Junghanns (2006).

Mentions: This equilibrium can be shifted in case the dissolution pressure increases (Figure 3), and thus the saturation solubility increases. Identical to liquids with different vapor pressures under normal conditions (micrometer droplet size), each drug crystal has a specific dissolution pressure in micrometer size. Figure 4 shows the increase in csfor the poorly soluble salt BaSO4 calculated using the Kelvin equation.


Nanocrystal technology, drug delivery and clinical applications.

Junghanns JU, Müller RH - Int J Nanomedicine (2008)

Increasing dissolution pressure over a flat surface, a microparticle, and a nanoparticle.Abbreviations: p, dissolution pressure; a, flat surface; b, microparticle; c, nanoparticle. Used with permission from Junghanns (2006).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2626933&req=5

f3-ijn-3-295: Increasing dissolution pressure over a flat surface, a microparticle, and a nanoparticle.Abbreviations: p, dissolution pressure; a, flat surface; b, microparticle; c, nanoparticle. Used with permission from Junghanns (2006).
Mentions: This equilibrium can be shifted in case the dissolution pressure increases (Figure 3), and thus the saturation solubility increases. Identical to liquids with different vapor pressures under normal conditions (micrometer droplet size), each drug crystal has a specific dissolution pressure in micrometer size. Figure 4 shows the increase in csfor the poorly soluble salt BaSO4 calculated using the Kelvin equation.

Bottom Line: The drug nanocrystals do not belong to the future; the first products are already on the market.The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product.Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, Berlin, Germany. juj@junghanns.net

ABSTRACT
Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physical properties which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. The drug nanocrystals do not belong to the future; the first products are already on the market. The industrially relevant production technologies, pearl milling and high pressure homogenization, are reviewed. The physics behind the drug nanocrystals and changes of their physical properties are discussed. The marketed products are presented and the special physical effects ofnanocrystals explained which are utilized in each market product. Examples of products in the development pipelines (clinical phases) are presented and the benefits for in vivo administration of drug nanocrystals are summarized in an overview.

Show MeSH