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Calcifying nanoparticles associated encrusted urinary bladder cystitis.

Jelic TM, Roque R, Yasar U, Tomchin SB, Serrato JM, Deem SG, Tierney JP, Chang HH - Int J Nanomedicine (2008)

Bottom Line: Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers.It is a very rare disease of controversial etiology.We pioneer the notion that calcifying nanoparticles are the causative agents of encrusted urinary bladder cystitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, CAMC, Memorial Hospital, 3200 MacCorkle Avenue, Charleston, WV 25304, USA. tomislav.jelic@camc.org

ABSTRACT
Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron microscopy of the calcified plaques of encrusted cystitis has revealed that the smallest formed particles (elementary units) of these calcifications are electron-dense shells surrounding an electron lucent core, diagnostic of calcifying nanoparticles (previously called nanobacteria). We pioneer the notion that calcifying nanoparticles are the causative agents of encrusted urinary bladder cystitis.

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Related in: MedlinePlus

Transmission electron microscopy image of encrusted cystitis calcifications (magnification 7,000) demonstrating multiple calcifying nanoparticles (some indicated by black thin arrows) with the characteristic electron-dense shell (ring structures 165 nm to 440 nm) surrounding a central electron lucent core. A thick black arrow points to the micron-size calcium aggregate about 3 square microns.
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f3-ijn-3-385: Transmission electron microscopy image of encrusted cystitis calcifications (magnification 7,000) demonstrating multiple calcifying nanoparticles (some indicated by black thin arrows) with the characteristic electron-dense shell (ring structures 165 nm to 440 nm) surrounding a central electron lucent core. A thick black arrow points to the micron-size calcium aggregate about 3 square microns.

Mentions: Transmission electron microscopy of the encrusted cystitis calcifications revealed that the smallest constituents of calcifications were not amorphous substance or granules but formed particles (elementary units of calcifications), composed of electron-dense shell rimming a central translucent core. They vary in size (Figures 3, 4) from165 nm to 440 nm and exhibit the size and spherical-to-ovoid shape diagnostic of calcifying nanoparticles/nanobacteria according to the relevant literature and our experience. It is easy to notice in Figure 3 that merging of the calcifying nanoparticles (like stacking of snowballs) forms micron-size calcium aggregates (micron-size plaques) measuring about 3 square microns that by further merging have ultimately become plaques of encrusted cystitis visible by light microscope (Figure 2) and naked eye (Figure 1).


Calcifying nanoparticles associated encrusted urinary bladder cystitis.

Jelic TM, Roque R, Yasar U, Tomchin SB, Serrato JM, Deem SG, Tierney JP, Chang HH - Int J Nanomedicine (2008)

Transmission electron microscopy image of encrusted cystitis calcifications (magnification 7,000) demonstrating multiple calcifying nanoparticles (some indicated by black thin arrows) with the characteristic electron-dense shell (ring structures 165 nm to 440 nm) surrounding a central electron lucent core. A thick black arrow points to the micron-size calcium aggregate about 3 square microns.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2626932&req=5

f3-ijn-3-385: Transmission electron microscopy image of encrusted cystitis calcifications (magnification 7,000) demonstrating multiple calcifying nanoparticles (some indicated by black thin arrows) with the characteristic electron-dense shell (ring structures 165 nm to 440 nm) surrounding a central electron lucent core. A thick black arrow points to the micron-size calcium aggregate about 3 square microns.
Mentions: Transmission electron microscopy of the encrusted cystitis calcifications revealed that the smallest constituents of calcifications were not amorphous substance or granules but formed particles (elementary units of calcifications), composed of electron-dense shell rimming a central translucent core. They vary in size (Figures 3, 4) from165 nm to 440 nm and exhibit the size and spherical-to-ovoid shape diagnostic of calcifying nanoparticles/nanobacteria according to the relevant literature and our experience. It is easy to notice in Figure 3 that merging of the calcifying nanoparticles (like stacking of snowballs) forms micron-size calcium aggregates (micron-size plaques) measuring about 3 square microns that by further merging have ultimately become plaques of encrusted cystitis visible by light microscope (Figure 2) and naked eye (Figure 1).

Bottom Line: Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers.It is a very rare disease of controversial etiology.We pioneer the notion that calcifying nanoparticles are the causative agents of encrusted urinary bladder cystitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, CAMC, Memorial Hospital, 3200 MacCorkle Avenue, Charleston, WV 25304, USA. tomislav.jelic@camc.org

ABSTRACT
Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron microscopy of the calcified plaques of encrusted cystitis has revealed that the smallest formed particles (elementary units) of these calcifications are electron-dense shells surrounding an electron lucent core, diagnostic of calcifying nanoparticles (previously called nanobacteria). We pioneer the notion that calcifying nanoparticles are the causative agents of encrusted urinary bladder cystitis.

Show MeSH
Related in: MedlinePlus