Limits...
Serial CT findings of Paragonimus infested dogs and the Micro-CT findings of the worm cysts.

Lee CH, Im JG, Goo JM, Lee HJ, Hong ST, Shen CH, Chung DH, Son KR, Chang JM, Eo H - Korean J Radiol (2007 Sep-Oct)

Bottom Line: Thereafter, subpleural ground-glass opacities and nodules with or without cavitary changes were persistently observed until day 180.After cavitary change of the nodules, the migratory features of the subpleural or peribronchial nodules were seen on all the serial CT scans.The CT findings of paragonimiasis depend on the migratory stage of the worms.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objective: To investigate the serial CT findings of Paragonimus westermani infected dogs and the microscopic structures of the worm cysts using Micro-CT.

Materials and methods: This study was approved by the committee on animal research at our institution. Fifteen dogs infected with P. westermani underwent serial contrast-enhanced CT scans at pre-infection, after 10 days of infection, and monthly thereafter until six months for determining the radiologic-pathologic correlation. Three dogs (one dog each time) were sacrificed at 1, 3 and 6 months, respectively. After fixation of the lungs, both multi-detector CT and Micro-CT were performed for examining the worm cysts.

Results: The initial findings were pleural effusion and/or subpleural ground-glass opacities or linear opacities at day 10. At day 30, subpleural and peribronchial nodules appeared with hydropneumothorax and abdominal or chest wall air bubbles. Cavitary change and bronchial dilatation began to be seen on CT scan at day 30 and this was mostly seen together with mediastinal lymphadenopathy at day 60. Thereafter, subpleural ground-glass opacities and nodules with or without cavitary changes were persistently observed until day 180. After cavitary change of the nodules, the migratory features of the subpleural or peribronchial nodules were seen on all the serial CT scans. Micro-CT showed that the cyst wall contained dilated interconnected tubular structures, which had communications with the cavity and the adjacent distal bronchus.

Conclusion: The CT findings of paragonimiasis depend on the migratory stage of the worms. The worm cyst can have numerous interconnected tubular channels within its own wall and these channels have connections with the cavity and the adjacent distal bronchus.

Show MeSH

Related in: MedlinePlus

Photograph and CT scan, for the fixed lungs prepared with Heitzman's method, of a dog after being infected for 30 days with P. westermani.A. Photograph of the fixed lung shows multiple pleural spots with areas of hemorrhages (black arrows).B. CT scan of the fixed lung shows a subpleural nodule with bronchioloectasis (black arrow).C. Consecutive contact radiographs show subpleural opacities (white arrows) directed toward the central airways.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2626818&req=5

Figure 6: Photograph and CT scan, for the fixed lungs prepared with Heitzman's method, of a dog after being infected for 30 days with P. westermani.A. Photograph of the fixed lung shows multiple pleural spots with areas of hemorrhages (black arrows).B. CT scan of the fixed lung shows a subpleural nodule with bronchioloectasis (black arrow).C. Consecutive contact radiographs show subpleural opacities (white arrows) directed toward the central airways.

Mentions: The sliced sections of the fixed lungs at one month showed subpleural consolidation or ground-glass opacity that was headed toward the central airways (Fig. 6). This pathologically corresponded to the hemorrhagic consolidations noted in all the specimens (Fig. 7). The CT scans of the fixed lungs showed some cystic lesions with internal crescentic structures that were not demonstrated on the in vivo CT scans. These internal structures were the adult worms inside the cysts (Fig. 7). The other findings that were observed on the CT scans of the fixed lungs were the same as those seen on the in vivo CT scans (Table 1).


Serial CT findings of Paragonimus infested dogs and the Micro-CT findings of the worm cysts.

Lee CH, Im JG, Goo JM, Lee HJ, Hong ST, Shen CH, Chung DH, Son KR, Chang JM, Eo H - Korean J Radiol (2007 Sep-Oct)

Photograph and CT scan, for the fixed lungs prepared with Heitzman's method, of a dog after being infected for 30 days with P. westermani.A. Photograph of the fixed lung shows multiple pleural spots with areas of hemorrhages (black arrows).B. CT scan of the fixed lung shows a subpleural nodule with bronchioloectasis (black arrow).C. Consecutive contact radiographs show subpleural opacities (white arrows) directed toward the central airways.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2626818&req=5

Figure 6: Photograph and CT scan, for the fixed lungs prepared with Heitzman's method, of a dog after being infected for 30 days with P. westermani.A. Photograph of the fixed lung shows multiple pleural spots with areas of hemorrhages (black arrows).B. CT scan of the fixed lung shows a subpleural nodule with bronchioloectasis (black arrow).C. Consecutive contact radiographs show subpleural opacities (white arrows) directed toward the central airways.
Mentions: The sliced sections of the fixed lungs at one month showed subpleural consolidation or ground-glass opacity that was headed toward the central airways (Fig. 6). This pathologically corresponded to the hemorrhagic consolidations noted in all the specimens (Fig. 7). The CT scans of the fixed lungs showed some cystic lesions with internal crescentic structures that were not demonstrated on the in vivo CT scans. These internal structures were the adult worms inside the cysts (Fig. 7). The other findings that were observed on the CT scans of the fixed lungs were the same as those seen on the in vivo CT scans (Table 1).

Bottom Line: Thereafter, subpleural ground-glass opacities and nodules with or without cavitary changes were persistently observed until day 180.After cavitary change of the nodules, the migratory features of the subpleural or peribronchial nodules were seen on all the serial CT scans.The CT findings of paragonimiasis depend on the migratory stage of the worms.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Objective: To investigate the serial CT findings of Paragonimus westermani infected dogs and the microscopic structures of the worm cysts using Micro-CT.

Materials and methods: This study was approved by the committee on animal research at our institution. Fifteen dogs infected with P. westermani underwent serial contrast-enhanced CT scans at pre-infection, after 10 days of infection, and monthly thereafter until six months for determining the radiologic-pathologic correlation. Three dogs (one dog each time) were sacrificed at 1, 3 and 6 months, respectively. After fixation of the lungs, both multi-detector CT and Micro-CT were performed for examining the worm cysts.

Results: The initial findings were pleural effusion and/or subpleural ground-glass opacities or linear opacities at day 10. At day 30, subpleural and peribronchial nodules appeared with hydropneumothorax and abdominal or chest wall air bubbles. Cavitary change and bronchial dilatation began to be seen on CT scan at day 30 and this was mostly seen together with mediastinal lymphadenopathy at day 60. Thereafter, subpleural ground-glass opacities and nodules with or without cavitary changes were persistently observed until day 180. After cavitary change of the nodules, the migratory features of the subpleural or peribronchial nodules were seen on all the serial CT scans. Micro-CT showed that the cyst wall contained dilated interconnected tubular structures, which had communications with the cavity and the adjacent distal bronchus.

Conclusion: The CT findings of paragonimiasis depend on the migratory stage of the worms. The worm cyst can have numerous interconnected tubular channels within its own wall and these channels have connections with the cavity and the adjacent distal bronchus.

Show MeSH
Related in: MedlinePlus