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The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors.

Park MJ, Cha ES, Kang BJ, Ihn YK, Baik JH - Korean J Radiol (2007 Sep-Oct)

Bottom Line: Fifty-six lesions were detected via DWI (detectability of 86.2%).The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

ABSTRACT

Objective: We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting breast tumors, as compared with the T1- and T2-weighted images.

Materials and methods: Forty-one female patients underwent breast MRI, and this included the T1-, T2-, DWI and dynamic contrast-enhanced images. Sixty-five enhancing lesions were detected on the dynamic contrast-enhanced images and we used this as a reference image for detecting tumor. Fifty-six breast lesions were detected on DWI and the histological diagnoses were as follows: 43 invasive ductal carcinomas, one mucinous carcinoma, one mixed infiltrative and mucinous carcinoma, seven ductal carcinomas in situ (DCIS), and four benign tumors. First, we compared the detectability of breast lesions on DWI with that of the T1- and T2-weighted images. We then compared the ADCs of the malignant and benign breast lesions to the ADCs of the normal fibroglandular tissue.

Results: Fifty-six lesions were detected via DWI (detectability of 86.2%). The detectabilities of breast lesions on the T1- and T2-weighted imaging were 61.5% (40/65) and 75.4% (49/65), respectively. The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).

Conclusion: DWI has a high sensitivity for detecting breast tumors, and especially for detecting malignant breast tumors. DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

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A 41-year-old woman with fibroadenoma that was confirmed by core-needle biopsy.A.The axial T1-weighted image shows a circumscribed oval iso-signal intensity mass in the right breast.B.The maximal intensity projection of the subtraction image shows homogeneous enhancement in the right breast. A nonspecific small enhancing nodule is also seen in the left breast. This left nodule showed typical benign features on the breast USG (not shown), so we did not perform core-needle biopsy.C.The diffusion-weighted image shows the mass to be a high-signal intensity lesion in the right breast.D.The axial plane apparent diffusion coefficient map shows the mixed yellow and red area, and the apparent diffusion coefficient value of this tumor was 1.63 × 10-3mm2/second.
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Figure 3: A 41-year-old woman with fibroadenoma that was confirmed by core-needle biopsy.A.The axial T1-weighted image shows a circumscribed oval iso-signal intensity mass in the right breast.B.The maximal intensity projection of the subtraction image shows homogeneous enhancement in the right breast. A nonspecific small enhancing nodule is also seen in the left breast. This left nodule showed typical benign features on the breast USG (not shown), so we did not perform core-needle biopsy.C.The diffusion-weighted image shows the mass to be a high-signal intensity lesion in the right breast.D.The axial plane apparent diffusion coefficient map shows the mixed yellow and red area, and the apparent diffusion coefficient value of this tumor was 1.63 × 10-3mm2/second.

Mentions: The mean ADC value of each type of lesion was invasive ductal carcinoma: 0.89 ± 0.18 × 10-3mm2/second, DCIS: 1.17 ± 0.18 × 10-3mm2/second, benign lesions: 1.41 ± 0.56 × 10-3mm2/second and normal breast parenchyma: 1.51 ± 0.29 × 10-3mm2/second (Table 2, Figs. 1-3). We excluded the ADC value of noninvasive ductal carcinomas such as one mucinous carcinoma and the one mixed infiltrative and mucinous carcinoma. The mean ADCs of the invasive ductal carcinoma and DCIS were significantly lower than that of the normal fibroglandular tissue (p < 0.05). Also, the mean ADC of the DCIS was statistically higher than that of the invasive ductal carcinoma (p < 0.05). In addition, the difference of the mean ADC values between invasive ductal carcinoma and the benign breast lesions was significant (p < 0.05) according to the Mann-Whitney test.


The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors.

Park MJ, Cha ES, Kang BJ, Ihn YK, Baik JH - Korean J Radiol (2007 Sep-Oct)

A 41-year-old woman with fibroadenoma that was confirmed by core-needle biopsy.A.The axial T1-weighted image shows a circumscribed oval iso-signal intensity mass in the right breast.B.The maximal intensity projection of the subtraction image shows homogeneous enhancement in the right breast. A nonspecific small enhancing nodule is also seen in the left breast. This left nodule showed typical benign features on the breast USG (not shown), so we did not perform core-needle biopsy.C.The diffusion-weighted image shows the mass to be a high-signal intensity lesion in the right breast.D.The axial plane apparent diffusion coefficient map shows the mixed yellow and red area, and the apparent diffusion coefficient value of this tumor was 1.63 × 10-3mm2/second.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2626812&req=5

Figure 3: A 41-year-old woman with fibroadenoma that was confirmed by core-needle biopsy.A.The axial T1-weighted image shows a circumscribed oval iso-signal intensity mass in the right breast.B.The maximal intensity projection of the subtraction image shows homogeneous enhancement in the right breast. A nonspecific small enhancing nodule is also seen in the left breast. This left nodule showed typical benign features on the breast USG (not shown), so we did not perform core-needle biopsy.C.The diffusion-weighted image shows the mass to be a high-signal intensity lesion in the right breast.D.The axial plane apparent diffusion coefficient map shows the mixed yellow and red area, and the apparent diffusion coefficient value of this tumor was 1.63 × 10-3mm2/second.
Mentions: The mean ADC value of each type of lesion was invasive ductal carcinoma: 0.89 ± 0.18 × 10-3mm2/second, DCIS: 1.17 ± 0.18 × 10-3mm2/second, benign lesions: 1.41 ± 0.56 × 10-3mm2/second and normal breast parenchyma: 1.51 ± 0.29 × 10-3mm2/second (Table 2, Figs. 1-3). We excluded the ADC value of noninvasive ductal carcinomas such as one mucinous carcinoma and the one mixed infiltrative and mucinous carcinoma. The mean ADCs of the invasive ductal carcinoma and DCIS were significantly lower than that of the normal fibroglandular tissue (p < 0.05). Also, the mean ADC of the DCIS was statistically higher than that of the invasive ductal carcinoma (p < 0.05). In addition, the difference of the mean ADC values between invasive ductal carcinoma and the benign breast lesions was significant (p < 0.05) according to the Mann-Whitney test.

Bottom Line: Fifty-six lesions were detected via DWI (detectability of 86.2%).The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

ABSTRACT

Objective: We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting breast tumors, as compared with the T1- and T2-weighted images.

Materials and methods: Forty-one female patients underwent breast MRI, and this included the T1-, T2-, DWI and dynamic contrast-enhanced images. Sixty-five enhancing lesions were detected on the dynamic contrast-enhanced images and we used this as a reference image for detecting tumor. Fifty-six breast lesions were detected on DWI and the histological diagnoses were as follows: 43 invasive ductal carcinomas, one mucinous carcinoma, one mixed infiltrative and mucinous carcinoma, seven ductal carcinomas in situ (DCIS), and four benign tumors. First, we compared the detectability of breast lesions on DWI with that of the T1- and T2-weighted images. We then compared the ADCs of the malignant and benign breast lesions to the ADCs of the normal fibroglandular tissue.

Results: Fifty-six lesions were detected via DWI (detectability of 86.2%). The detectabilities of breast lesions on the T1- and T2-weighted imaging were 61.5% (40/65) and 75.4% (49/65), respectively. The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).

Conclusion: DWI has a high sensitivity for detecting breast tumors, and especially for detecting malignant breast tumors. DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

Show MeSH
Related in: MedlinePlus