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The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors.

Park MJ, Cha ES, Kang BJ, Ihn YK, Baik JH - Korean J Radiol (2007 Sep-Oct)

Bottom Line: Fifty-six lesions were detected via DWI (detectability of 86.2%).The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

ABSTRACT

Objective: We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting breast tumors, as compared with the T1- and T2-weighted images.

Materials and methods: Forty-one female patients underwent breast MRI, and this included the T1-, T2-, DWI and dynamic contrast-enhanced images. Sixty-five enhancing lesions were detected on the dynamic contrast-enhanced images and we used this as a reference image for detecting tumor. Fifty-six breast lesions were detected on DWI and the histological diagnoses were as follows: 43 invasive ductal carcinomas, one mucinous carcinoma, one mixed infiltrative and mucinous carcinoma, seven ductal carcinomas in situ (DCIS), and four benign tumors. First, we compared the detectability of breast lesions on DWI with that of the T1- and T2-weighted images. We then compared the ADCs of the malignant and benign breast lesions to the ADCs of the normal fibroglandular tissue.

Results: Fifty-six lesions were detected via DWI (detectability of 86.2%). The detectabilities of breast lesions on the T1- and T2-weighted imaging were 61.5% (40/65) and 75.4% (49/65), respectively. The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).

Conclusion: DWI has a high sensitivity for detecting breast tumors, and especially for detecting malignant breast tumors. DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

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A 53-year-old woman with ductal carcinoma in situ.A.The axial T1-weighted image shows segmentally distributed, asymmetric, iso-signal intensity, non-mass lesion in the left breast.B.The maximal intensity projection of a subtraction image shows heterogeneous clumpy enhancement in the left breast.C.The diffusion-weighted image shows the main lesion to be a high-signal intensity lesion.D.The axial plane apparent diffusion coefficient map shows a mixed green and yellow area and the apparent diffusion coefficient value of this breast tumor was 1.43 × 10-3mm2/second.
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Figure 2: A 53-year-old woman with ductal carcinoma in situ.A.The axial T1-weighted image shows segmentally distributed, asymmetric, iso-signal intensity, non-mass lesion in the left breast.B.The maximal intensity projection of a subtraction image shows heterogeneous clumpy enhancement in the left breast.C.The diffusion-weighted image shows the main lesion to be a high-signal intensity lesion.D.The axial plane apparent diffusion coefficient map shows a mixed green and yellow area and the apparent diffusion coefficient value of this breast tumor was 1.43 × 10-3mm2/second.


The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors.

Park MJ, Cha ES, Kang BJ, Ihn YK, Baik JH - Korean J Radiol (2007 Sep-Oct)

A 53-year-old woman with ductal carcinoma in situ.A.The axial T1-weighted image shows segmentally distributed, asymmetric, iso-signal intensity, non-mass lesion in the left breast.B.The maximal intensity projection of a subtraction image shows heterogeneous clumpy enhancement in the left breast.C.The diffusion-weighted image shows the main lesion to be a high-signal intensity lesion.D.The axial plane apparent diffusion coefficient map shows a mixed green and yellow area and the apparent diffusion coefficient value of this breast tumor was 1.43 × 10-3mm2/second.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2626812&req=5

Figure 2: A 53-year-old woman with ductal carcinoma in situ.A.The axial T1-weighted image shows segmentally distributed, asymmetric, iso-signal intensity, non-mass lesion in the left breast.B.The maximal intensity projection of a subtraction image shows heterogeneous clumpy enhancement in the left breast.C.The diffusion-weighted image shows the main lesion to be a high-signal intensity lesion.D.The axial plane apparent diffusion coefficient map shows a mixed green and yellow area and the apparent diffusion coefficient value of this breast tumor was 1.43 × 10-3mm2/second.
Bottom Line: Fifty-six lesions were detected via DWI (detectability of 86.2%).The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

ABSTRACT

Objective: We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting breast tumors, as compared with the T1- and T2-weighted images.

Materials and methods: Forty-one female patients underwent breast MRI, and this included the T1-, T2-, DWI and dynamic contrast-enhanced images. Sixty-five enhancing lesions were detected on the dynamic contrast-enhanced images and we used this as a reference image for detecting tumor. Fifty-six breast lesions were detected on DWI and the histological diagnoses were as follows: 43 invasive ductal carcinomas, one mucinous carcinoma, one mixed infiltrative and mucinous carcinoma, seven ductal carcinomas in situ (DCIS), and four benign tumors. First, we compared the detectability of breast lesions on DWI with that of the T1- and T2-weighted images. We then compared the ADCs of the malignant and benign breast lesions to the ADCs of the normal fibroglandular tissue.

Results: Fifty-six lesions were detected via DWI (detectability of 86.2%). The detectabilities of breast lesions on the T1- and T2-weighted imaging were 61.5% (40/65) and 75.4% (49/65), respectively. The mean ADCs of the invasive ductal carcinoma (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second).

Conclusion: DWI has a high sensitivity for detecting breast tumors, and especially for detecting malignant breast tumors. DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

Show MeSH
Related in: MedlinePlus