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Learning to tolerate ourselves

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On page 139, Duty et al. find self-reactive B cells in healthy adults that might harm their own body if given the chance... In healthy mice, autoimmunity is avoided because most self-reactive escapees, which classically express high levels of IgD and reduced IgM, are arrested in an anergic state... But until now, a similar population of anergic, autoreactive B cells hadn't been found in humans... Duty et al. have now spotted these cells in the blood of healthy adults, where they accounted for 2.5% of peripheral B cells... Autoreactive B cells are common in patients with autoimmune diseases, such as lupus or rheumatoid arthritis (RA)... And the authors suspect that the new population may contain the precursors of these troublemaking cells... Lapses in early steps of self-tolerance have been shown to contribute to disease in patients with lupus or RA... Alternatively, suggests author Patrick Wilson, anergy may fail in these patients, allowing self-sabotaging cells to run free... Why the body silences these potentially mutinous cells after they escape rather than putting them to death is unclear... Perhaps, suggests Wilson, a limited amount of autoimmunity isn't such a bad thing, as long as it's not chronic... For example, anergic cells might help attack pathogens disguised as self-antigens.

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A population of mature B cells from healthy people produce autoreactive antibodies that bind to DNA (green).
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fig1: A population of mature B cells from healthy people produce autoreactive antibodies that bind to DNA (green).


Learning to tolerate ourselves
A population of mature B cells from healthy people produce autoreactive antibodies that bind to DNA (green).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2626678&req=5

fig1: A population of mature B cells from healthy people produce autoreactive antibodies that bind to DNA (green).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

On page 139, Duty et al. find self-reactive B cells in healthy adults that might harm their own body if given the chance... In healthy mice, autoimmunity is avoided because most self-reactive escapees, which classically express high levels of IgD and reduced IgM, are arrested in an anergic state... But until now, a similar population of anergic, autoreactive B cells hadn't been found in humans... Duty et al. have now spotted these cells in the blood of healthy adults, where they accounted for 2.5% of peripheral B cells... Autoreactive B cells are common in patients with autoimmune diseases, such as lupus or rheumatoid arthritis (RA)... And the authors suspect that the new population may contain the precursors of these troublemaking cells... Lapses in early steps of self-tolerance have been shown to contribute to disease in patients with lupus or RA... Alternatively, suggests author Patrick Wilson, anergy may fail in these patients, allowing self-sabotaging cells to run free... Why the body silences these potentially mutinous cells after they escape rather than putting them to death is unclear... Perhaps, suggests Wilson, a limited amount of autoimmunity isn't such a bad thing, as long as it's not chronic... For example, anergic cells might help attack pathogens disguised as self-antigens.

No MeSH data available.