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Squamous cell carcinoma of the breast: a case report.

Flikweert ER, Hofstee M, Liem MS - World J Surg Oncol (2008)

Bottom Line: There is a possible explanation for these findings.After the operation the pathological examination revealed a primary squamous cell carcinoma of the breast.Therefore, pathological examination of these apparent benign abnormalities is mandatory.

View Article: PubMed Central - HTML - PubMed

Affiliation: Deventer Hospital, Department of Surgery, Postbus 5001, 7400 GC Deventer, the Netherlands. elviraflikweert@hotmail.com

ABSTRACT

Background: Squamous cells are normally not found inside the breast, so a primary squamous cell carcinoma of the breast is an exceptional phenomenon. There is a possible explanation for these findings.

Case presentation: A 72-year-old woman presented with a breast abnormality suspected for breast carcinoma. After the operation the pathological examination revealed a primary squamous cell carcinoma of the breast.

Conclusion: The presentation of squamous cell carcinoma could be similar to that of an adenocarcinoma. However, a squamous cell carcinoma of the breast could also develop from a complicated breast cyst or abscess. Therefore, pathological examination of these apparent benign abnormalities is mandatory.

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Squamous cell carcinoma surrounding a pre-existent milk duct, central in the picture.
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Figure 2: Squamous cell carcinoma surrounding a pre-existent milk duct, central in the picture.

Mentions: Under the nipple, subcutaneously, 44 megabecquerel Technetium99 nanocolloid was injected five hours before the operation. However on the scan made just before the operation, there was no sentinel node visible. At the beginning of the operation patent blue dye was injected to locate the sentinel node. During the operation three blue lymph vessels were seen. There were, however, more enlarged lymph nodes without blue coloring but with pathologic aspect. It was decided to perform a regular lymphadenectomy of the axilla, without removing the highest level nodes. The postoperative course was uncomplicated. She left the hospital five days after the operation, the drains were removed prior to discharge. Pathological examination showed a locally cornified squamous cell carcinoma with a mitosis activity index of more than 20 (figure 2). The conclusion was a radical excision of a moderate differentiated squamous cell carcinoma of the breast, with a size of four centimeters. The Bloom Richardson score was eight, this means high grade malignant. In the preparation eleven lymph nodes were found of which two had metastasis of squamous cell carcinoma. There was no metastasis in the lymph nodes located right underneath the axillary vein. Hence, the tumour was classified as pT2N1Mx breast carcinoma. Determination of the hormone receptors showed positivity for estrogen receptor, the progesterone receptor identification was negative. There was no amplification of the her2neu receptor.


Squamous cell carcinoma of the breast: a case report.

Flikweert ER, Hofstee M, Liem MS - World J Surg Oncol (2008)

Squamous cell carcinoma surrounding a pre-existent milk duct, central in the picture.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2626594&req=5

Figure 2: Squamous cell carcinoma surrounding a pre-existent milk duct, central in the picture.
Mentions: Under the nipple, subcutaneously, 44 megabecquerel Technetium99 nanocolloid was injected five hours before the operation. However on the scan made just before the operation, there was no sentinel node visible. At the beginning of the operation patent blue dye was injected to locate the sentinel node. During the operation three blue lymph vessels were seen. There were, however, more enlarged lymph nodes without blue coloring but with pathologic aspect. It was decided to perform a regular lymphadenectomy of the axilla, without removing the highest level nodes. The postoperative course was uncomplicated. She left the hospital five days after the operation, the drains were removed prior to discharge. Pathological examination showed a locally cornified squamous cell carcinoma with a mitosis activity index of more than 20 (figure 2). The conclusion was a radical excision of a moderate differentiated squamous cell carcinoma of the breast, with a size of four centimeters. The Bloom Richardson score was eight, this means high grade malignant. In the preparation eleven lymph nodes were found of which two had metastasis of squamous cell carcinoma. There was no metastasis in the lymph nodes located right underneath the axillary vein. Hence, the tumour was classified as pT2N1Mx breast carcinoma. Determination of the hormone receptors showed positivity for estrogen receptor, the progesterone receptor identification was negative. There was no amplification of the her2neu receptor.

Bottom Line: There is a possible explanation for these findings.After the operation the pathological examination revealed a primary squamous cell carcinoma of the breast.Therefore, pathological examination of these apparent benign abnormalities is mandatory.

View Article: PubMed Central - HTML - PubMed

Affiliation: Deventer Hospital, Department of Surgery, Postbus 5001, 7400 GC Deventer, the Netherlands. elviraflikweert@hotmail.com

ABSTRACT

Background: Squamous cells are normally not found inside the breast, so a primary squamous cell carcinoma of the breast is an exceptional phenomenon. There is a possible explanation for these findings.

Case presentation: A 72-year-old woman presented with a breast abnormality suspected for breast carcinoma. After the operation the pathological examination revealed a primary squamous cell carcinoma of the breast.

Conclusion: The presentation of squamous cell carcinoma could be similar to that of an adenocarcinoma. However, a squamous cell carcinoma of the breast could also develop from a complicated breast cyst or abscess. Therefore, pathological examination of these apparent benign abnormalities is mandatory.

Show MeSH
Related in: MedlinePlus