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slik Gene Controls Cell Growth and Survival

View Article: PubMed Central

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Cellular signaling regulates two crucial development mechanisms, apoptosis (programmed cell death) and cell proliferation, which work like chisel and clay to sculpt multiplying masses of cells into, say, a fly wing or a human finger... Controlled by multiple signals operating at fixed intervals, the entwined pathways can be steered off-course by a single defect in the communication network, resulting in the death of a healthy cell, for example, or the survival of a damaged cell... Following that tradition, Stephen Cohen and David Hipfner have identified a gene critical to Drosophila development that juggles cell growth and survival signals to help promote cell growth and prevent inappropriate apoptosis... They searched for genes associated with changes in tissue growth in fruitfly wings and identified some that can cause tissue “overgrowth”—abnormally large masses resulting either from cells growing faster than they divide or from cells escaping proliferation controls when they are overexpressed... To investigate the function of slik in Drosophila, the researchers removed the gene and then studied the physical and cellular effects... They found striking delays in growth and developmental timing and showed that these effects result largely from the demise of the slik-deficient cells... Thus, cells without slik appear to have an intrinsic survival defect, suggesting that slik prevents apoptosis... When slik is overexpressed, cell proliferation increases, but so does apoptosis... This coupling of cell growth and cell death is characteristic of oncogenes (cancer-causing genes), and slik also seems to function in both pathways... This may keep an individual cell under the control of its neighbors, who collectively monitor the needs of the organism... For a cell to respond to a signal by dividing rather than dying, it must get the appropriate signs from its comrades. slik, the authors demonstrate, is a key factor in determining whether a cell lives or dies... Whether its mammalian counterparts play a similar role is yet to be determined.

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slik overexpression induces apoptosis
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pbio.0000043-g001: slik overexpression induces apoptosis


slik Gene Controls Cell Growth and Survival
slik overexpression induces apoptosis
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC261883&req=5

pbio.0000043-g001: slik overexpression induces apoptosis

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Cellular signaling regulates two crucial development mechanisms, apoptosis (programmed cell death) and cell proliferation, which work like chisel and clay to sculpt multiplying masses of cells into, say, a fly wing or a human finger... Controlled by multiple signals operating at fixed intervals, the entwined pathways can be steered off-course by a single defect in the communication network, resulting in the death of a healthy cell, for example, or the survival of a damaged cell... Following that tradition, Stephen Cohen and David Hipfner have identified a gene critical to Drosophila development that juggles cell growth and survival signals to help promote cell growth and prevent inappropriate apoptosis... They searched for genes associated with changes in tissue growth in fruitfly wings and identified some that can cause tissue “overgrowth”—abnormally large masses resulting either from cells growing faster than they divide or from cells escaping proliferation controls when they are overexpressed... To investigate the function of slik in Drosophila, the researchers removed the gene and then studied the physical and cellular effects... They found striking delays in growth and developmental timing and showed that these effects result largely from the demise of the slik-deficient cells... Thus, cells without slik appear to have an intrinsic survival defect, suggesting that slik prevents apoptosis... When slik is overexpressed, cell proliferation increases, but so does apoptosis... This coupling of cell growth and cell death is characteristic of oncogenes (cancer-causing genes), and slik also seems to function in both pathways... This may keep an individual cell under the control of its neighbors, who collectively monitor the needs of the organism... For a cell to respond to a signal by dividing rather than dying, it must get the appropriate signs from its comrades. slik, the authors demonstrate, is a key factor in determining whether a cell lives or dies... Whether its mammalian counterparts play a similar role is yet to be determined.

No MeSH data available.