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Genomics research and malaria control: great expectations.

Alibu VP, Egwang TG - PLoS Biol. (2003)

View Article: PubMed Central - PubMed

Affiliation: Zentrum für Moleculare Biologie at the University of Heidelberg in Germany.

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The protozoan parasite Plasmodium falciparum causes falciparum malaria, a fatal parasitic disease in humans, and is transmitted by Anopheles mosquito vectors (predominantly the Anopheles gambiae complex and An. funestus in Africa)... The unraveling of the genomes of humans, P. falciparum, and An. gambiae has ushered in a new era of hope that genomics research will result in the development of new and better in tools for malaria control... The apicoplast is essential for parasite survival and functions in the anabolic synthesis of fatty acids, isoprenoids, and heme... These essential metabolic pathways are not present in humans and are therefore ideal targets for the development of safe antimalarial drugs... Analyses of the proteomes of parasites that have been exposed to distinct environmental stimuli (e.g., chloroquine versus saline control) or that manifest distinct phenotypes (drug resistant versus drug sensitive) might also facilitate the identification of biochemical drug targets and of the specific proteins involved in drug resistance... Comparative genomics (the comparison of genomes of related species), on the other hand, will yield invaluable insights about the biology of and the pathogenesis of disease associated with different parasites, i.e., P. falciparum on the one hand and P. vivax on the other... The ability to introduce foreign genes into Anopheles vectors is an exciting advance that might facilitate the development of transgenic mosquitoes that do not transmit malaria parasites... The training must extend to other aspects of genomics and include infrastructure development... There is considerable optimism that genomics research will result in new drugs, vaccines, diagnostics, and tools for malarial vector control... Strong linkages between genomics research and national malarial control programs will facilitate the translation of research findings into intervention tools... As it is for all new technologies, it might also be important for the communities in endemic countries to have a greater awareness and understanding of genomics research... This will enhance acceptance of the products and improve informed consent... There is therefore a unique opportunity for collaborations between social-economic scientists and genomics researchers.

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Patients at Apac HospitalOf the patients waiting at the Out-Patient Department of Apac Hospital in Northern Uganda, the majority are mothers of children under 5 years old with malaria. (Photograph by Toshihiro Horii, Department of Molecular Protozoology, Research Institute for Microbial Diseases, University of Osaka, Osaka, Japan.)
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pbio.0000039-g001: Patients at Apac HospitalOf the patients waiting at the Out-Patient Department of Apac Hospital in Northern Uganda, the majority are mothers of children under 5 years old with malaria. (Photograph by Toshihiro Horii, Department of Molecular Protozoology, Research Institute for Microbial Diseases, University of Osaka, Osaka, Japan.)


Genomics research and malaria control: great expectations.

Alibu VP, Egwang TG - PLoS Biol. (2003)

Patients at Apac HospitalOf the patients waiting at the Out-Patient Department of Apac Hospital in Northern Uganda, the majority are mothers of children under 5 years old with malaria. (Photograph by Toshihiro Horii, Department of Molecular Protozoology, Research Institute for Microbial Diseases, University of Osaka, Osaka, Japan.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC261879&req=5

pbio.0000039-g001: Patients at Apac HospitalOf the patients waiting at the Out-Patient Department of Apac Hospital in Northern Uganda, the majority are mothers of children under 5 years old with malaria. (Photograph by Toshihiro Horii, Department of Molecular Protozoology, Research Institute for Microbial Diseases, University of Osaka, Osaka, Japan.)

View Article: PubMed Central - PubMed

Affiliation: Zentrum für Moleculare Biologie at the University of Heidelberg in Germany.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The protozoan parasite Plasmodium falciparum causes falciparum malaria, a fatal parasitic disease in humans, and is transmitted by Anopheles mosquito vectors (predominantly the Anopheles gambiae complex and An. funestus in Africa)... The unraveling of the genomes of humans, P. falciparum, and An. gambiae has ushered in a new era of hope that genomics research will result in the development of new and better in tools for malaria control... The apicoplast is essential for parasite survival and functions in the anabolic synthesis of fatty acids, isoprenoids, and heme... These essential metabolic pathways are not present in humans and are therefore ideal targets for the development of safe antimalarial drugs... Analyses of the proteomes of parasites that have been exposed to distinct environmental stimuli (e.g., chloroquine versus saline control) or that manifest distinct phenotypes (drug resistant versus drug sensitive) might also facilitate the identification of biochemical drug targets and of the specific proteins involved in drug resistance... Comparative genomics (the comparison of genomes of related species), on the other hand, will yield invaluable insights about the biology of and the pathogenesis of disease associated with different parasites, i.e., P. falciparum on the one hand and P. vivax on the other... The ability to introduce foreign genes into Anopheles vectors is an exciting advance that might facilitate the development of transgenic mosquitoes that do not transmit malaria parasites... The training must extend to other aspects of genomics and include infrastructure development... There is considerable optimism that genomics research will result in new drugs, vaccines, diagnostics, and tools for malarial vector control... Strong linkages between genomics research and national malarial control programs will facilitate the translation of research findings into intervention tools... As it is for all new technologies, it might also be important for the communities in endemic countries to have a greater awareness and understanding of genomics research... This will enhance acceptance of the products and improve informed consent... There is therefore a unique opportunity for collaborations between social-economic scientists and genomics researchers.

Show MeSH
Related in: MedlinePlus