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Inducible nitric oxide expression correlates with the level of inflammation in periapical cysts.

Matsumoto MA, Ribeiro DA - Eur J Dent (2007)

Bottom Line: Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn's test. iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly.Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, University of Sacred Heart, USC, Bauru, SP, Brazil.

ABSTRACT

Objectives: In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones.

Methods: 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn's test.

Results: iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.

Conclusions: Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

No MeSH data available.


Related in: MedlinePlus

iNOS labeling index in reduced epithelium and stratified squamous epithelium of dental follicles. Values were expressed as means ± S.D. *: P<.05 when compared to mild inflammation.
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f1-0010212: iNOS labeling index in reduced epithelium and stratified squamous epithelium of dental follicles. Values were expressed as means ± S.D. *: P<.05 when compared to mild inflammation.

Mentions: iNOS stain was detected throughout the epithelium and subepithelial fibroblasts, and inflammatory cells in all cases indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation observed. For example, a statistically significant increase (P< .05) of iNOS expression was observed in periapical cysts with higher levels of inflammation when compared to the tissues with low levels of inflammatory infiltrate. Such data are presented in Figure 1. No immunoreactivity was detected in the negative control.


Inducible nitric oxide expression correlates with the level of inflammation in periapical cysts.

Matsumoto MA, Ribeiro DA - Eur J Dent (2007)

iNOS labeling index in reduced epithelium and stratified squamous epithelium of dental follicles. Values were expressed as means ± S.D. *: P<.05 when compared to mild inflammation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609916&req=5

f1-0010212: iNOS labeling index in reduced epithelium and stratified squamous epithelium of dental follicles. Values were expressed as means ± S.D. *: P<.05 when compared to mild inflammation.
Mentions: iNOS stain was detected throughout the epithelium and subepithelial fibroblasts, and inflammatory cells in all cases indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation observed. For example, a statistically significant increase (P< .05) of iNOS expression was observed in periapical cysts with higher levels of inflammation when compared to the tissues with low levels of inflammatory infiltrate. Such data are presented in Figure 1. No immunoreactivity was detected in the negative control.

Bottom Line: Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn's test. iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly.Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, University of Sacred Heart, USC, Bauru, SP, Brazil.

ABSTRACT

Objectives: In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones.

Methods: 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn's test.

Results: iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.

Conclusions: Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts.

No MeSH data available.


Related in: MedlinePlus