Limits...
Human rhinovirus group C infection in children with lower respiratory tract infection.

Xiang Z, Gonzalez R, Xie Z, Xiao Y, Chen L, Li Y, Liu C, Hu Y, Yao Y, Qian S, Geng R, Vernet G, Paranhos-Baccalà G, Shen K, Jin Q, Wang J - Emerging Infect. Dis. (2008)

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Human rhinoviruses (HRVs), members of the family Picornaviridae, were first isolated in 1956 ; to date, >100 serotypes have been identified on the basis of nucleotide sequence homologies... The most common clinical findings were cough (14/14), fever (9/14), and abnormal breath sounds on auscultation (11/14)... Radiographic results were available for 10 of the 14 HRV-C–positive patients, all of whom had increased lung markings or patchy shadows... Six sequences (BCH221, BCH264, BCH200, BCH341, BCH217, and BCH250) displayed high similarity to HRV C025 (EF582386) from Hong Kong ; 2 sequences (BCH249 and BCH343) displayed high similarity to NAT083 (EF077264) from the United States and Picornaviridae strain 06-646 (EU081811) from Germany... BCH242 was similar to Picornaviridae strain tu403 (EU081795) from Germany... Although HRV-C strains belonging to different gene clusters cocirculate, some genetically close strains dominated during certain periods, e.g., the C025-like strain (6/14) was dominant during the study period... A similar distribution pattern is observed in epidemics of HRV-A and HRV-B... In conclusion, HRV-C strains were detected in hospitalized children with lower acute RTIs in Beijing... Co-infections were common and complex, which indicates that the role of HRV-C in patients with multiple infections should be further investigated... Our findings provide additional evidence that HRV-C is spreading globally and suggest that HRV-C infections should be considered a serious public health concern.

Show MeSH

Related in: MedlinePlus

Phylogenetic analysis of the viruses detected in this study based on the nucleotide sequences of the virus capsid protein (VP)4/VP2 region. Using the VP4/VP2 nucleotide sequence (258 nt), we performed neighbor-joining analysis by applying the Kimura 2-parameter model in MEGA software version 4.0 (www.megasoftware.net). Bootstrap values from 1,000 replicates are shown next to the branches. The scale bar indicates evolutionary distance. Representative viruses from the different human respiratory virus (HRV) groups are included. GenBank accession numbers for reference sequences are indicated in parentheses.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2609892&req=5

Figure 1: Phylogenetic analysis of the viruses detected in this study based on the nucleotide sequences of the virus capsid protein (VP)4/VP2 region. Using the VP4/VP2 nucleotide sequence (258 nt), we performed neighbor-joining analysis by applying the Kimura 2-parameter model in MEGA software version 4.0 (www.megasoftware.net). Bootstrap values from 1,000 replicates are shown next to the branches. The scale bar indicates evolutionary distance. Representative viruses from the different human respiratory virus (HRV) groups are included. GenBank accession numbers for reference sequences are indicated in parentheses.

Mentions: Phylogenetic analysis showed that the 14 sequences obtained during this study (GenBank accession nos. EU687515–EU687528) together with previously reported sequences formed a novel group of rhinoviruses (Figure). Six sequences (BCH221, BCH264, BCH200, BCH341, BCH217, and BCH250) displayed high similarity to HRV C025 (EF582386) from Hong Kong (4); 2 sequences (BCH249 and BCH343) displayed high similarity to NAT083 (EF077264) from the United States (3) and Picornaviridae strain 06-646 (EU081811) from Germany (5). BCH242 was similar to Picornaviridae strain tu403 (EU081795) from Germany (5). The other 5 strains were homologous to strains from Australia (EU155152–EU155154, EU155158) (2,7). These findings suggest that, as in other countries (5), the HRV-C strains circulating in China are diverse. Although HRV-C strains belonging to different gene clusters cocirculate, some genetically close strains dominated during certain periods, e.g., the C025-like strain (6/14) was dominant during the study period. A similar distribution pattern is observed in epidemics of HRV-A and HRV-B (9,10).


Human rhinovirus group C infection in children with lower respiratory tract infection.

Xiang Z, Gonzalez R, Xie Z, Xiao Y, Chen L, Li Y, Liu C, Hu Y, Yao Y, Qian S, Geng R, Vernet G, Paranhos-Baccalà G, Shen K, Jin Q, Wang J - Emerging Infect. Dis. (2008)

Phylogenetic analysis of the viruses detected in this study based on the nucleotide sequences of the virus capsid protein (VP)4/VP2 region. Using the VP4/VP2 nucleotide sequence (258 nt), we performed neighbor-joining analysis by applying the Kimura 2-parameter model in MEGA software version 4.0 (www.megasoftware.net). Bootstrap values from 1,000 replicates are shown next to the branches. The scale bar indicates evolutionary distance. Representative viruses from the different human respiratory virus (HRV) groups are included. GenBank accession numbers for reference sequences are indicated in parentheses.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609892&req=5

Figure 1: Phylogenetic analysis of the viruses detected in this study based on the nucleotide sequences of the virus capsid protein (VP)4/VP2 region. Using the VP4/VP2 nucleotide sequence (258 nt), we performed neighbor-joining analysis by applying the Kimura 2-parameter model in MEGA software version 4.0 (www.megasoftware.net). Bootstrap values from 1,000 replicates are shown next to the branches. The scale bar indicates evolutionary distance. Representative viruses from the different human respiratory virus (HRV) groups are included. GenBank accession numbers for reference sequences are indicated in parentheses.
Mentions: Phylogenetic analysis showed that the 14 sequences obtained during this study (GenBank accession nos. EU687515–EU687528) together with previously reported sequences formed a novel group of rhinoviruses (Figure). Six sequences (BCH221, BCH264, BCH200, BCH341, BCH217, and BCH250) displayed high similarity to HRV C025 (EF582386) from Hong Kong (4); 2 sequences (BCH249 and BCH343) displayed high similarity to NAT083 (EF077264) from the United States (3) and Picornaviridae strain 06-646 (EU081811) from Germany (5). BCH242 was similar to Picornaviridae strain tu403 (EU081795) from Germany (5). The other 5 strains were homologous to strains from Australia (EU155152–EU155154, EU155158) (2,7). These findings suggest that, as in other countries (5), the HRV-C strains circulating in China are diverse. Although HRV-C strains belonging to different gene clusters cocirculate, some genetically close strains dominated during certain periods, e.g., the C025-like strain (6/14) was dominant during the study period. A similar distribution pattern is observed in epidemics of HRV-A and HRV-B (9,10).

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Human rhinoviruses (HRVs), members of the family Picornaviridae, were first isolated in 1956 ; to date, >100 serotypes have been identified on the basis of nucleotide sequence homologies... The most common clinical findings were cough (14/14), fever (9/14), and abnormal breath sounds on auscultation (11/14)... Radiographic results were available for 10 of the 14 HRV-C–positive patients, all of whom had increased lung markings or patchy shadows... Six sequences (BCH221, BCH264, BCH200, BCH341, BCH217, and BCH250) displayed high similarity to HRV C025 (EF582386) from Hong Kong ; 2 sequences (BCH249 and BCH343) displayed high similarity to NAT083 (EF077264) from the United States and Picornaviridae strain 06-646 (EU081811) from Germany... BCH242 was similar to Picornaviridae strain tu403 (EU081795) from Germany... Although HRV-C strains belonging to different gene clusters cocirculate, some genetically close strains dominated during certain periods, e.g., the C025-like strain (6/14) was dominant during the study period... A similar distribution pattern is observed in epidemics of HRV-A and HRV-B... In conclusion, HRV-C strains were detected in hospitalized children with lower acute RTIs in Beijing... Co-infections were common and complex, which indicates that the role of HRV-C in patients with multiple infections should be further investigated... Our findings provide additional evidence that HRV-C is spreading globally and suggest that HRV-C infections should be considered a serious public health concern.

Show MeSH
Related in: MedlinePlus