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Extended sequence typing of Campylobacter spp., United Kingdom.

Dingle KE, McCarthy ND, Cody AJ, Peto TE, Maiden MC - Emerging Infect. Dis. (2008)

Bottom Line: Supplementing Campylobacter spp. multilocus sequence typing with nucleotide sequence typing of 3 antigen genes increased the discriminatory index achieved from 0.975 to 0.992 among 620 clinical isolates from Oxfordshire, United Kingdom.This enhanced typing scheme enabled identification of clusters and retained data required for long-range epidemiologic comparisons of isolates.

View Article: PubMed Central - PubMed

Affiliation: John Radcliffe Hospital, Oxford, UK.

ABSTRACT
Supplementing Campylobacter spp. multilocus sequence typing with nucleotide sequence typing of 3 antigen genes increased the discriminatory index achieved from 0.975 to 0.992 among 620 clinical isolates from Oxfordshire, United Kingdom. This enhanced typing scheme enabled identification of clusters and retained data required for long-range epidemiologic comparisons of isolates.

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Relative abundance of clonal complexes of Campylobacter spp. detected in Oxfordshire, United Kingdom, during a 1-year study compared with clonal complexes detected in 3 other studies of human Campylobacter spp. infections in northwestern England (7), New South Wales, Australia (8), and Curaçao (9).
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Figure 1: Relative abundance of clonal complexes of Campylobacter spp. detected in Oxfordshire, United Kingdom, during a 1-year study compared with clonal complexes detected in 3 other studies of human Campylobacter spp. infections in northwestern England (7), New South Wales, Australia (8), and Curaçao (9).

Mentions: A comparison of our results with published population-based 7-locus MLST studies showed that the relative abundance of different clonal complexes in northwestern England from April 2003 through March 2004 was similar (7), presumably reflecting widely distributed foods in the United Kingdom. An exception was ST-574 complex, the central genotype, which represented >5% of cases in Oxfordshire but was absent from northwestern England. The clonal complex distribution of 171 isolates collected in New South Wales, Australia (8), was distinct from the 2 English datasets, although many clonal complexes were present in all 3 datasets. Fewer clonal complexes, with different relative abundances, were present in a dataset from Curaçao (9), likely because of different infection sources in the Dutch West Indies (Figure 1).


Extended sequence typing of Campylobacter spp., United Kingdom.

Dingle KE, McCarthy ND, Cody AJ, Peto TE, Maiden MC - Emerging Infect. Dis. (2008)

Relative abundance of clonal complexes of Campylobacter spp. detected in Oxfordshire, United Kingdom, during a 1-year study compared with clonal complexes detected in 3 other studies of human Campylobacter spp. infections in northwestern England (7), New South Wales, Australia (8), and Curaçao (9).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609887&req=5

Figure 1: Relative abundance of clonal complexes of Campylobacter spp. detected in Oxfordshire, United Kingdom, during a 1-year study compared with clonal complexes detected in 3 other studies of human Campylobacter spp. infections in northwestern England (7), New South Wales, Australia (8), and Curaçao (9).
Mentions: A comparison of our results with published population-based 7-locus MLST studies showed that the relative abundance of different clonal complexes in northwestern England from April 2003 through March 2004 was similar (7), presumably reflecting widely distributed foods in the United Kingdom. An exception was ST-574 complex, the central genotype, which represented >5% of cases in Oxfordshire but was absent from northwestern England. The clonal complex distribution of 171 isolates collected in New South Wales, Australia (8), was distinct from the 2 English datasets, although many clonal complexes were present in all 3 datasets. Fewer clonal complexes, with different relative abundances, were present in a dataset from Curaçao (9), likely because of different infection sources in the Dutch West Indies (Figure 1).

Bottom Line: Supplementing Campylobacter spp. multilocus sequence typing with nucleotide sequence typing of 3 antigen genes increased the discriminatory index achieved from 0.975 to 0.992 among 620 clinical isolates from Oxfordshire, United Kingdom.This enhanced typing scheme enabled identification of clusters and retained data required for long-range epidemiologic comparisons of isolates.

View Article: PubMed Central - PubMed

Affiliation: John Radcliffe Hospital, Oxford, UK.

ABSTRACT
Supplementing Campylobacter spp. multilocus sequence typing with nucleotide sequence typing of 3 antigen genes increased the discriminatory index achieved from 0.975 to 0.992 among 620 clinical isolates from Oxfordshire, United Kingdom. This enhanced typing scheme enabled identification of clusters and retained data required for long-range epidemiologic comparisons of isolates.

Show MeSH
Related in: MedlinePlus