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Risk factors for Nipah virus encephalitis in Bangladesh.

Montgomery JM, Hossain MJ, Gurley E, Carroll GD, Croisier A, Bertherat E, Asgari N, Formenty P, Keeler N, Comer J, Bell MR, Akram K, Molla AR, Zaman K, Islam MR, Wagoner K, Mills JN, Rollin PE, Ksiazek TG, Breiman RF - Emerging Infect. Dis. (2008)

Bottom Line: Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis.We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host.Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

View Article: PubMed Central - PubMed

Affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. jmontgomery@cdc.gov

ABSTRACT
Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-infinity) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

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Related in: MedlinePlus

Epidemic curve of Nipah virus outbreak in Goalando, Bangladesh, in 2004, demonstrating household clustering. Households 1 and 4 each had 2 cases, household 5 had 3 cases, and all other households, single cases.
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Figure 2: Epidemic curve of Nipah virus outbreak in Goalando, Bangladesh, in 2004, demonstrating household clustering. Households 1 and 4 each had 2 cases, household 5 had 3 cases, and all other households, single cases.

Mentions: Top: Distribution of Nipah virus case (n = 12) and control (n = 36) households within the outbreak/study site of Goalando township, Bangladesh, January 2004. Number in the yellow triangle corresponds to household no. in Figure 2. Map also shows extreme habitat disturbance; areas under cultivation (for rice, sugar cane) are highlighted with “C,” and remaining trees (fruit trees and bamboo stands) with “T.” Bottom: Location of outbreak village.


Risk factors for Nipah virus encephalitis in Bangladesh.

Montgomery JM, Hossain MJ, Gurley E, Carroll GD, Croisier A, Bertherat E, Asgari N, Formenty P, Keeler N, Comer J, Bell MR, Akram K, Molla AR, Zaman K, Islam MR, Wagoner K, Mills JN, Rollin PE, Ksiazek TG, Breiman RF - Emerging Infect. Dis. (2008)

Epidemic curve of Nipah virus outbreak in Goalando, Bangladesh, in 2004, demonstrating household clustering. Households 1 and 4 each had 2 cases, household 5 had 3 cases, and all other households, single cases.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609878&req=5

Figure 2: Epidemic curve of Nipah virus outbreak in Goalando, Bangladesh, in 2004, demonstrating household clustering. Households 1 and 4 each had 2 cases, household 5 had 3 cases, and all other households, single cases.
Mentions: Top: Distribution of Nipah virus case (n = 12) and control (n = 36) households within the outbreak/study site of Goalando township, Bangladesh, January 2004. Number in the yellow triangle corresponds to household no. in Figure 2. Map also shows extreme habitat disturbance; areas under cultivation (for rice, sugar cane) are highlighted with “C,” and remaining trees (fruit trees and bamboo stands) with “T.” Bottom: Location of outbreak village.

Bottom Line: Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis.We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host.Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

View Article: PubMed Central - PubMed

Affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. jmontgomery@cdc.gov

ABSTRACT
Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-infinity) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

Show MeSH
Related in: MedlinePlus