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Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

Shah NK, Alker AP, Sem R, Susanti AI, Muth S, Maguire JD, Duong S, Ariey F, Meshnick SR, Wongsrichanalai C - Emerging Infect. Dis. (2008)

Bottom Line: We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1.The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

View Article: PubMed Central - PubMed

Affiliation: University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.

ABSTRACT
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

Show MeSH
Median values and interquartile ranges of pfmdr1 copy number across 5 surveillance sites in Cambodia, May 2004–December 2006. Kg., Kampong.
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Related In: Results  -  Collection


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Figure 2: Median values and interquartile ranges of pfmdr1 copy number across 5 surveillance sites in Cambodia, May 2004–December 2006. Kg., Kampong.

Mentions: pfmdr1 copy numbers ranged from 0.6 to 6.3, and 167 (23.5%) of 712 samples had >1.5 copies. The median and distribution of pfmdr1 copy number varied by site and were highest in the 3 western Cambodian sites (Figure 2). The proportion of samples with >1.5 pfmdr1 copies was greater in western than eastern Cambodia (52.7% vs. 6.4%, odds ratio [OR] = 16.2, 95% CI 10.3–25.3). The prevalence of parasite samples with amplified pfmdr1 varied by site and differed in the prevalence of 2 and >3 copies of pfmdr1 (Figure 1).


Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

Shah NK, Alker AP, Sem R, Susanti AI, Muth S, Maguire JD, Duong S, Ariey F, Meshnick SR, Wongsrichanalai C - Emerging Infect. Dis. (2008)

Median values and interquartile ranges of pfmdr1 copy number across 5 surveillance sites in Cambodia, May 2004–December 2006. Kg., Kampong.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609877&req=5

Figure 2: Median values and interquartile ranges of pfmdr1 copy number across 5 surveillance sites in Cambodia, May 2004–December 2006. Kg., Kampong.
Mentions: pfmdr1 copy numbers ranged from 0.6 to 6.3, and 167 (23.5%) of 712 samples had >1.5 copies. The median and distribution of pfmdr1 copy number varied by site and were highest in the 3 western Cambodian sites (Figure 2). The proportion of samples with >1.5 pfmdr1 copies was greater in western than eastern Cambodia (52.7% vs. 6.4%, odds ratio [OR] = 16.2, 95% CI 10.3–25.3). The prevalence of parasite samples with amplified pfmdr1 varied by site and differed in the prevalence of 2 and >3 copies of pfmdr1 (Figure 1).

Bottom Line: We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1.The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

View Article: PubMed Central - PubMed

Affiliation: University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.

ABSTRACT
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

Show MeSH