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Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

Shah NK, Alker AP, Sem R, Susanti AI, Muth S, Maguire JD, Duong S, Ariey F, Meshnick SR, Wongsrichanalai C - Emerging Infect. Dis. (2008)

Bottom Line: We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1.The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

View Article: PubMed Central - PubMed

Affiliation: University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.

ABSTRACT
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

Show MeSH
Map of Cambodia with locations of surveillance sites and proportion of isolates containing 1, 2, or >3 copies of pfmdr1, May 2004–December 2006.
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Related In: Results  -  Collection


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Figure 1: Map of Cambodia with locations of surveillance sites and proportion of isolates containing 1, 2, or >3 copies of pfmdr1, May 2004–December 2006.

Mentions: Clinical isolates of P. falciparum were collected from 5 sites across Cambodia (Figure 1): Pailin, Kampong Seila, Chumkiri (western), Memut, and Rattanakiri (eastern) during 2004–2006. Study participants included patients who were seen at health centers with uncomplicated falciparum malaria, including mixed infections. Fifty-six samples from patients in Pailin had been previously analyzed (6). Institutional review board approvals were obtained from the Cambodian National Ethics Committee for Health Research, the US Naval Medical Research Unit No. 2, and the University of North Carolina at Chapel Hill (UNC).


Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

Shah NK, Alker AP, Sem R, Susanti AI, Muth S, Maguire JD, Duong S, Ariey F, Meshnick SR, Wongsrichanalai C - Emerging Infect. Dis. (2008)

Map of Cambodia with locations of surveillance sites and proportion of isolates containing 1, 2, or >3 copies of pfmdr1, May 2004–December 2006.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609877&req=5

Figure 1: Map of Cambodia with locations of surveillance sites and proportion of isolates containing 1, 2, or >3 copies of pfmdr1, May 2004–December 2006.
Mentions: Clinical isolates of P. falciparum were collected from 5 sites across Cambodia (Figure 1): Pailin, Kampong Seila, Chumkiri (western), Memut, and Rattanakiri (eastern) during 2004–2006. Study participants included patients who were seen at health centers with uncomplicated falciparum malaria, including mixed infections. Fifty-six samples from patients in Pailin had been previously analyzed (6). Institutional review board approvals were obtained from the Cambodian National Ethics Committee for Health Research, the US Naval Medical Research Unit No. 2, and the University of North Carolina at Chapel Hill (UNC).

Bottom Line: We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1.The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

View Article: PubMed Central - PubMed

Affiliation: University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.

ABSTRACT
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

Show MeSH