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Deaths from norovirus among the elderly, England and Wales.

Harris JP, Edmunds WJ, Pebody R, Brown DW, Lopman BA - Emerging Infect. Dis. (2008)

Bottom Line: The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006.Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results).An estimated 80 deaths each year in this age group may be associated with norovirus infection.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infections, GEZI, Health Protection Agency, London, UK. john.harris@hpa.org.uk

ABSTRACT
The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006. Regression analysis was used to model monthly counts of gastrointestinal pathogens in fecal samples from infected patients against monthly counts of deaths from infectious and noninfectious intestinal diseases. Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results). Model results suggest that 20% (13.3%-26.8%) of deaths in persons >or=65 years of age caused by infectious intestinal disease other than Clostridium difficile were associated with norovirus infection in this period and that 13% (7.5%-18.5%) of deaths caused by noninfectious intestinal disease were associated with norovirus. An estimated 80 deaths each year in this age group may be associated with norovirus infection.

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Related in: MedlinePlus

Observed and expected monthly deaths in persons >65 years of age from infectious intestinal diseases (A) and noninfectious intestinal diseases (B), derived from the most parsimonious models.
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Figure 3: Observed and expected monthly deaths in persons >65 years of age from infectious intestinal diseases (A) and noninfectious intestinal diseases (B), derived from the most parsimonious models.

Mentions: The model estimates that during 2001–2006, a total of 228 deaths from infectious ID were associated with norovirus infection, which represents 20% (13.3%–26.8%) of deaths from infectious ID in those >65 years of age; 225 (13% [7.5%–18.5%]) of deaths from noninfectious ID were associated with norovirus. Thus, the annual average number of deaths (January to December) from both infectious ID and noninfectious ID was 38; however, when looking at the period from July to June in each year, to account for the norovirus season, the average was ≈40 each season (Table 3). Figure 3, panels A, B, illustrates that models fit better to the deaths from infectious ID but still show some association with the deaths from noninfectious ID.


Deaths from norovirus among the elderly, England and Wales.

Harris JP, Edmunds WJ, Pebody R, Brown DW, Lopman BA - Emerging Infect. Dis. (2008)

Observed and expected monthly deaths in persons >65 years of age from infectious intestinal diseases (A) and noninfectious intestinal diseases (B), derived from the most parsimonious models.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609872&req=5

Figure 3: Observed and expected monthly deaths in persons >65 years of age from infectious intestinal diseases (A) and noninfectious intestinal diseases (B), derived from the most parsimonious models.
Mentions: The model estimates that during 2001–2006, a total of 228 deaths from infectious ID were associated with norovirus infection, which represents 20% (13.3%–26.8%) of deaths from infectious ID in those >65 years of age; 225 (13% [7.5%–18.5%]) of deaths from noninfectious ID were associated with norovirus. Thus, the annual average number of deaths (January to December) from both infectious ID and noninfectious ID was 38; however, when looking at the period from July to June in each year, to account for the norovirus season, the average was ≈40 each season (Table 3). Figure 3, panels A, B, illustrates that models fit better to the deaths from infectious ID but still show some association with the deaths from noninfectious ID.

Bottom Line: The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006.Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results).An estimated 80 deaths each year in this age group may be associated with norovirus infection.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infections, GEZI, Health Protection Agency, London, UK. john.harris@hpa.org.uk

ABSTRACT
The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006. Regression analysis was used to model monthly counts of gastrointestinal pathogens in fecal samples from infected patients against monthly counts of deaths from infectious and noninfectious intestinal diseases. Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results). Model results suggest that 20% (13.3%-26.8%) of deaths in persons >or=65 years of age caused by infectious intestinal disease other than Clostridium difficile were associated with norovirus infection in this period and that 13% (7.5%-18.5%) of deaths caused by noninfectious intestinal disease were associated with norovirus. An estimated 80 deaths each year in this age group may be associated with norovirus infection.

Show MeSH
Related in: MedlinePlus