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Deaths from norovirus among the elderly, England and Wales.

Harris JP, Edmunds WJ, Pebody R, Brown DW, Lopman BA - Emerging Infect. Dis. (2008)

Bottom Line: The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006.Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results).An estimated 80 deaths each year in this age group may be associated with norovirus infection.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infections, GEZI, Health Protection Agency, London, UK. john.harris@hpa.org.uk

ABSTRACT
The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006. Regression analysis was used to model monthly counts of gastrointestinal pathogens in fecal samples from infected patients against monthly counts of deaths from infectious and noninfectious intestinal diseases. Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results). Model results suggest that 20% (13.3%-26.8%) of deaths in persons >or=65 years of age caused by infectious intestinal disease other than Clostridium difficile were associated with norovirus infection in this period and that 13% (7.5%-18.5%) of deaths caused by noninfectious intestinal disease were associated with norovirus. An estimated 80 deaths each year in this age group may be associated with norovirus infection.

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Seasonality of positive laboratory reports of viral (A), bacterial (B), and parasitic (C) pathogens, 2001–2006, persons >65 years of age.
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Figure 2: Seasonality of positive laboratory reports of viral (A), bacterial (B), and parasitic (C) pathogens, 2001–2006, persons >65 years of age.

Mentions: During 2001–2006, a total of 1,136 deaths were recorded with any code for infectious ID and 1,736 for noninfectious ID (Figure 1). Infectious and noninfectious ID–associated deaths were correlated (R2 = 0.33, p = 0.10, Figure 1) and exhibited a wintertime seasonal pattern. Over the same period (2001–2006) in England and Wales, a total of 65,932 laboratory reports of the pathogens of interest were submitted for those >65 years of age. Summertime seasonality of the major bacterial pathogens and the wintertime seasonality of viral pathogens for this age group are illustrated in Figure 2, panels A–C.


Deaths from norovirus among the elderly, England and Wales.

Harris JP, Edmunds WJ, Pebody R, Brown DW, Lopman BA - Emerging Infect. Dis. (2008)

Seasonality of positive laboratory reports of viral (A), bacterial (B), and parasitic (C) pathogens, 2001–2006, persons >65 years of age.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2609872&req=5

Figure 2: Seasonality of positive laboratory reports of viral (A), bacterial (B), and parasitic (C) pathogens, 2001–2006, persons >65 years of age.
Mentions: During 2001–2006, a total of 1,136 deaths were recorded with any code for infectious ID and 1,736 for noninfectious ID (Figure 1). Infectious and noninfectious ID–associated deaths were correlated (R2 = 0.33, p = 0.10, Figure 1) and exhibited a wintertime seasonal pattern. Over the same period (2001–2006) in England and Wales, a total of 65,932 laboratory reports of the pathogens of interest were submitted for those >65 years of age. Summertime seasonality of the major bacterial pathogens and the wintertime seasonality of viral pathogens for this age group are illustrated in Figure 2, panels A–C.

Bottom Line: The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006.Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results).An estimated 80 deaths each year in this age group may be associated with norovirus infection.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infections, GEZI, Health Protection Agency, London, UK. john.harris@hpa.org.uk

ABSTRACT
The number of deaths in England and Wales associated with gastrointestinal pathogens, norovirus in particular, in persons >or=65 years was estimated for 2001-2006. Regression analysis was used to model monthly counts of gastrointestinal pathogens in fecal samples from infected patients against monthly counts of deaths from infectious and noninfectious intestinal diseases. Data came from the Office of National Statistics (death registrations from local registrars) and from the Health Protection Agency (laboratory results). Model results suggest that 20% (13.3%-26.8%) of deaths in persons >or=65 years of age caused by infectious intestinal disease other than Clostridium difficile were associated with norovirus infection in this period and that 13% (7.5%-18.5%) of deaths caused by noninfectious intestinal disease were associated with norovirus. An estimated 80 deaths each year in this age group may be associated with norovirus infection.

Show MeSH
Related in: MedlinePlus