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HCV coinfection associated with slower disease progression in HIV-infected former plasma donors naïve to ART.

Zhang X, Xu J, Peng H, Ma Y, Han L, Ruan Y, Su B, Wang N, Shao Y - PLoS ONE (2008)

Bottom Line: During the 33-month follow-up, only 35% (7 out of 20 cases) HIV-1 mono-infected subjects remained their CD4+ T-cell counts above 200 cells/microl and retained on the cohort study, which was significantly lower than 56% (75 out of 135 cases) for HIV/HCV group and 69% (9 out of 13 cases) for HIV/HCV/Toxoplasma group (p<0.05).In accordance with those observations, HIV viral loads in HIV mono-infection group were consistently higher than that in HIV/HCV group though statistical significances were only reached at baseline (p = 0.04).It will be highly interesting to further explore the underlying mechanism for this observation in the future.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing, China.

ABSTRACT

Background: It remains controversial how HCV coinfection influences the disease progression during HIV-1 infection. This study aims to define the influence of HCV infection on the replication of HIV-1 and the disease progression in HIV-infected former plasma donors (FPDs) naïve to ART.

Methodology/principal findings: 168 HIV-1-infected FPDs were enrolled into a cohort study from Anhui province in central China, and thereafter monitored at month 3, 9, 15, 21 and 33. Fresh whole blood samples were used for CD4+ T-cell counting. Their plasma samples were collected and stored for quantification of HIV-1 viral loads and for determination of HCV and Toxoplasma. Out of 168 HIV-infected FBDs, 11.9% (20 cases), 80.4% (135 cases) and 7.7% (13 cases) were infected with HIV-1 alone, HIV-1/HCV and HIV/HCV/Toxoplasma, respectively. During the 33-month follow-up, only 35% (7 out of 20 cases) HIV-1 mono-infected subjects remained their CD4+ T-cell counts above 200 cells/microl and retained on the cohort study, which was significantly lower than 56% (75 out of 135 cases) for HIV/HCV group and 69% (9 out of 13 cases) for HIV/HCV/Toxoplasma group (p<0.05). CD4+ T cells in HIV mono infection group were consistently lower than that in HIV/HCV group (p = 0.04, 0.18, 0.03 and 0.04 for baseline, month 9, month 21 and month 33 visit, respectively). In accordance with those observations, HIV viral loads in HIV mono-infection group were consistently higher than that in HIV/HCV group though statistical significances were only reached at baseline (p = 0.04).

Conclusions/significance: These data indicated HCV coinfection with HIV-1 is associated with the slower disease progression at the very late stage when comparing with HIV-1 mono-infection. The coinfection of Toxoplasma with HIV and HCV did not exert additional influence on the disease progression. It will be highly interesting to further explore the underlying mechanism for this observation in the future.

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Characterization of the cohort at baseline.a, the reverse association of CD4+ T-cell counts and viral loads in the study subjects at baseline. The X axis indicated CD4+ T-cell counts (cells/µl), and Y axis indicated viral loads; GraphPad Prism 5 was used to generate the trend line and r value. b and c, CD4+ T-cell counts and viral load among different groups at baseline. The X axis indicated different groups including HIV (HIV-1 mono infection), HIV/HCV (dual infection), and HIV/HCV/Tox (triple infection of HIV, HCV and toxoplasma). The Y axis indicated CD4+ T-cell counts (1b) and viral load (1c); d, the ratio of CD4+ T cells to viral loads among different groups, the ratios were calculated by dividing CD4+ T-cell counts by the value of viral loads in log10.
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pone-0003992-g001: Characterization of the cohort at baseline.a, the reverse association of CD4+ T-cell counts and viral loads in the study subjects at baseline. The X axis indicated CD4+ T-cell counts (cells/µl), and Y axis indicated viral loads; GraphPad Prism 5 was used to generate the trend line and r value. b and c, CD4+ T-cell counts and viral load among different groups at baseline. The X axis indicated different groups including HIV (HIV-1 mono infection), HIV/HCV (dual infection), and HIV/HCV/Tox (triple infection of HIV, HCV and toxoplasma). The Y axis indicated CD4+ T-cell counts (1b) and viral load (1c); d, the ratio of CD4+ T cells to viral loads among different groups, the ratios were calculated by dividing CD4+ T-cell counts by the value of viral loads in log10.

Mentions: The overall CD4+ T-cell counts were negatively associated with plasma viral loads (r = −0.19) at baseline (Fig. 1a), and this negative association were consistently observed during the follow-up visits (data not shown), indicating that the viral replication is the driving force for disease progression in the FBDs population. To determine the effect of HCV coinfection with HIV-1 on the disease progression, we compared HIV viral loads and CD4+ T-cell counts at baseline among HIV-1 mono-infection (N = 20 cases), dual infection of HIV plus HCV (N = 135 cases) and triple infection of HIV, HCV and toxoplasma (N = 13 cases). The reason to include the toxoplasma is to test whether the toxoplasma coinfection with HIV and HCV could exact any additional effect on disease progression.


HCV coinfection associated with slower disease progression in HIV-infected former plasma donors naïve to ART.

Zhang X, Xu J, Peng H, Ma Y, Han L, Ruan Y, Su B, Wang N, Shao Y - PLoS ONE (2008)

Characterization of the cohort at baseline.a, the reverse association of CD4+ T-cell counts and viral loads in the study subjects at baseline. The X axis indicated CD4+ T-cell counts (cells/µl), and Y axis indicated viral loads; GraphPad Prism 5 was used to generate the trend line and r value. b and c, CD4+ T-cell counts and viral load among different groups at baseline. The X axis indicated different groups including HIV (HIV-1 mono infection), HIV/HCV (dual infection), and HIV/HCV/Tox (triple infection of HIV, HCV and toxoplasma). The Y axis indicated CD4+ T-cell counts (1b) and viral load (1c); d, the ratio of CD4+ T cells to viral loads among different groups, the ratios were calculated by dividing CD4+ T-cell counts by the value of viral loads in log10.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2602976&req=5

pone-0003992-g001: Characterization of the cohort at baseline.a, the reverse association of CD4+ T-cell counts and viral loads in the study subjects at baseline. The X axis indicated CD4+ T-cell counts (cells/µl), and Y axis indicated viral loads; GraphPad Prism 5 was used to generate the trend line and r value. b and c, CD4+ T-cell counts and viral load among different groups at baseline. The X axis indicated different groups including HIV (HIV-1 mono infection), HIV/HCV (dual infection), and HIV/HCV/Tox (triple infection of HIV, HCV and toxoplasma). The Y axis indicated CD4+ T-cell counts (1b) and viral load (1c); d, the ratio of CD4+ T cells to viral loads among different groups, the ratios were calculated by dividing CD4+ T-cell counts by the value of viral loads in log10.
Mentions: The overall CD4+ T-cell counts were negatively associated with plasma viral loads (r = −0.19) at baseline (Fig. 1a), and this negative association were consistently observed during the follow-up visits (data not shown), indicating that the viral replication is the driving force for disease progression in the FBDs population. To determine the effect of HCV coinfection with HIV-1 on the disease progression, we compared HIV viral loads and CD4+ T-cell counts at baseline among HIV-1 mono-infection (N = 20 cases), dual infection of HIV plus HCV (N = 135 cases) and triple infection of HIV, HCV and toxoplasma (N = 13 cases). The reason to include the toxoplasma is to test whether the toxoplasma coinfection with HIV and HCV could exact any additional effect on disease progression.

Bottom Line: During the 33-month follow-up, only 35% (7 out of 20 cases) HIV-1 mono-infected subjects remained their CD4+ T-cell counts above 200 cells/microl and retained on the cohort study, which was significantly lower than 56% (75 out of 135 cases) for HIV/HCV group and 69% (9 out of 13 cases) for HIV/HCV/Toxoplasma group (p<0.05).In accordance with those observations, HIV viral loads in HIV mono-infection group were consistently higher than that in HIV/HCV group though statistical significances were only reached at baseline (p = 0.04).It will be highly interesting to further explore the underlying mechanism for this observation in the future.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing, China.

ABSTRACT

Background: It remains controversial how HCV coinfection influences the disease progression during HIV-1 infection. This study aims to define the influence of HCV infection on the replication of HIV-1 and the disease progression in HIV-infected former plasma donors (FPDs) naïve to ART.

Methodology/principal findings: 168 HIV-1-infected FPDs were enrolled into a cohort study from Anhui province in central China, and thereafter monitored at month 3, 9, 15, 21 and 33. Fresh whole blood samples were used for CD4+ T-cell counting. Their plasma samples were collected and stored for quantification of HIV-1 viral loads and for determination of HCV and Toxoplasma. Out of 168 HIV-infected FBDs, 11.9% (20 cases), 80.4% (135 cases) and 7.7% (13 cases) were infected with HIV-1 alone, HIV-1/HCV and HIV/HCV/Toxoplasma, respectively. During the 33-month follow-up, only 35% (7 out of 20 cases) HIV-1 mono-infected subjects remained their CD4+ T-cell counts above 200 cells/microl and retained on the cohort study, which was significantly lower than 56% (75 out of 135 cases) for HIV/HCV group and 69% (9 out of 13 cases) for HIV/HCV/Toxoplasma group (p<0.05). CD4+ T cells in HIV mono infection group were consistently lower than that in HIV/HCV group (p = 0.04, 0.18, 0.03 and 0.04 for baseline, month 9, month 21 and month 33 visit, respectively). In accordance with those observations, HIV viral loads in HIV mono-infection group were consistently higher than that in HIV/HCV group though statistical significances were only reached at baseline (p = 0.04).

Conclusions/significance: These data indicated HCV coinfection with HIV-1 is associated with the slower disease progression at the very late stage when comparing with HIV-1 mono-infection. The coinfection of Toxoplasma with HIV and HCV did not exert additional influence on the disease progression. It will be highly interesting to further explore the underlying mechanism for this observation in the future.

Show MeSH
Related in: MedlinePlus