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Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors.

Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ - PPAR Res (2008)

Bottom Line: Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARgamma and alpha, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form.The transactivities of both full length and ligand-binding domain (LBD) of PPARgamma and PPARalpha are activated by cinnamon as evidenced by reporter gene assays.These data suggest that cinnamon in its water extract form can act as a dual activator of PPARgamma and alpha, and may be an alternative to PPARgamma activator in managing obesity-related diabetes and hyperlipidemia.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, China.

ABSTRACT
Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARgamma and alpha, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors gamma and alpha (PPARgamma/alpha) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARgamma and PPARalpha are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARgamma and alpha, and may be an alternative to PPARgamma activator in managing obesity-related diabetes and hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus

CE reduced the fasted blood glucose level andimproved glucose tolerance in DIO and db/db mice. Mice wereadministered vehicle alone, or CE (equivalent to 400 mg cinnamon powder kg • day •) for 3 weeks(DIO) or 2 weeks (db/db). The blood glucose levels weremeasured in tail vein and the basal glucose levels were shown at 0 minute. (a)DIO C57BL/6J mice were fasted overnight and glucose levels were measured at 9:00 am at the end treatment. NF: normal food fed mice; HF: high-fat food-induced mice; CE:cinnamon water extract; (b) fasted DIO mice were intraperitoneally injected with 2 g glucose • kg− body weight and glucose tolerance determined at the time indicated; (c) db/db Micewere fasted for 6 hours and the fasted blood glucose was measured. CONT: vehicle;(d) glucose tolerance wasdetermined following 2 g glucose • kg−1 body weight intraperitoneal injection in db/db mice. The data arepresented as mean ± SE, n = 5 for each group. (b) *P < .05 versus HF group or (d) vehicle control (cont).
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fig1: CE reduced the fasted blood glucose level andimproved glucose tolerance in DIO and db/db mice. Mice wereadministered vehicle alone, or CE (equivalent to 400 mg cinnamon powder kg • day •) for 3 weeks(DIO) or 2 weeks (db/db). The blood glucose levels weremeasured in tail vein and the basal glucose levels were shown at 0 minute. (a)DIO C57BL/6J mice were fasted overnight and glucose levels were measured at 9:00 am at the end treatment. NF: normal food fed mice; HF: high-fat food-induced mice; CE:cinnamon water extract; (b) fasted DIO mice were intraperitoneally injected with 2 g glucose • kg− body weight and glucose tolerance determined at the time indicated; (c) db/db Micewere fasted for 6 hours and the fasted blood glucose was measured. CONT: vehicle;(d) glucose tolerance wasdetermined following 2 g glucose • kg−1 body weight intraperitoneal injection in db/db mice. The data arepresented as mean ± SE, n = 5 for each group. (b) *P < .05 versus HF group or (d) vehicle control (cont).

Mentions: To evaluate whether CE hasany influence on glucose tolerance, IPGTT determination was carried outfor overnight fasted DIO mice at 0 minute, 15 minutes, 30 minutes, 60 minutes,and 120 minutes following 2 g/kg glucose intraperitoneal injection DIOmice developed severe insulin resistance after 5 months high-fat food inductions,and serum insulin level increased nearly 3 times compared to the control miceon normal diet (see Table 1). Three weeks ofCE treatment not only reduced fasted glucose level but also improved glucosetolerance markedly (see Figures 1(a) and 1(b)). The serum insulin level wasdecreased after CE treatment (Table 1). Similar effects were observed on db/db mice as demonstrated in Figures 1(c)and 1(d). Our results suggested that CE is capable of improving insulinsensitivities in both high-fat diet-induced diabetic mice and db/db mice.


Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors.

Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ - PPAR Res (2008)

CE reduced the fasted blood glucose level andimproved glucose tolerance in DIO and db/db mice. Mice wereadministered vehicle alone, or CE (equivalent to 400 mg cinnamon powder kg • day •) for 3 weeks(DIO) or 2 weeks (db/db). The blood glucose levels weremeasured in tail vein and the basal glucose levels were shown at 0 minute. (a)DIO C57BL/6J mice were fasted overnight and glucose levels were measured at 9:00 am at the end treatment. NF: normal food fed mice; HF: high-fat food-induced mice; CE:cinnamon water extract; (b) fasted DIO mice were intraperitoneally injected with 2 g glucose • kg− body weight and glucose tolerance determined at the time indicated; (c) db/db Micewere fasted for 6 hours and the fasted blood glucose was measured. CONT: vehicle;(d) glucose tolerance wasdetermined following 2 g glucose • kg−1 body weight intraperitoneal injection in db/db mice. The data arepresented as mean ± SE, n = 5 for each group. (b) *P < .05 versus HF group or (d) vehicle control (cont).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2602825&req=5

fig1: CE reduced the fasted blood glucose level andimproved glucose tolerance in DIO and db/db mice. Mice wereadministered vehicle alone, or CE (equivalent to 400 mg cinnamon powder kg • day •) for 3 weeks(DIO) or 2 weeks (db/db). The blood glucose levels weremeasured in tail vein and the basal glucose levels were shown at 0 minute. (a)DIO C57BL/6J mice were fasted overnight and glucose levels were measured at 9:00 am at the end treatment. NF: normal food fed mice; HF: high-fat food-induced mice; CE:cinnamon water extract; (b) fasted DIO mice were intraperitoneally injected with 2 g glucose • kg− body weight and glucose tolerance determined at the time indicated; (c) db/db Micewere fasted for 6 hours and the fasted blood glucose was measured. CONT: vehicle;(d) glucose tolerance wasdetermined following 2 g glucose • kg−1 body weight intraperitoneal injection in db/db mice. The data arepresented as mean ± SE, n = 5 for each group. (b) *P < .05 versus HF group or (d) vehicle control (cont).
Mentions: To evaluate whether CE hasany influence on glucose tolerance, IPGTT determination was carried outfor overnight fasted DIO mice at 0 minute, 15 minutes, 30 minutes, 60 minutes,and 120 minutes following 2 g/kg glucose intraperitoneal injection DIOmice developed severe insulin resistance after 5 months high-fat food inductions,and serum insulin level increased nearly 3 times compared to the control miceon normal diet (see Table 1). Three weeks ofCE treatment not only reduced fasted glucose level but also improved glucosetolerance markedly (see Figures 1(a) and 1(b)). The serum insulin level wasdecreased after CE treatment (Table 1). Similar effects were observed on db/db mice as demonstrated in Figures 1(c)and 1(d). Our results suggested that CE is capable of improving insulinsensitivities in both high-fat diet-induced diabetic mice and db/db mice.

Bottom Line: Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARgamma and alpha, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form.The transactivities of both full length and ligand-binding domain (LBD) of PPARgamma and PPARalpha are activated by cinnamon as evidenced by reporter gene assays.These data suggest that cinnamon in its water extract form can act as a dual activator of PPARgamma and alpha, and may be an alternative to PPARgamma activator in managing obesity-related diabetes and hyperlipidemia.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, China.

ABSTRACT
Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARgamma and alpha, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors gamma and alpha (PPARgamma/alpha) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARgamma and PPARalpha are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARgamma and alpha, and may be an alternative to PPARgamma activator in managing obesity-related diabetes and hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus