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Fatal Rickettsia conorii subsp. israelensis infection, Israel.

Weinberger M, Keysary A, Sandbank J, Zaidenstein R, Itzhaki A, Strenger C, Leitner M, Paddock CD, Eremeeva ME - Emerging Infect. Dis. (2008)

Bottom Line: Underdiagnosis of fatal spotted fever may be attributed to nonspecific clinical features and insensitive acute-phase serologic studies.We describe the importance of molecular and immunohistochemical methods in establishing the postmortem diagnosis of locally acquired Israeli spotted fever due to Rickettsia conorii subsp. israelensis in a traveler returning to Israel from India.

View Article: PubMed Central - PubMed

Affiliation: Infectious Diseases Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel. miriw@netvision.net.il

ABSTRACT
Underdiagnosis of fatal spotted fever may be attributed to nonspecific clinical features and insensitive acute-phase serologic studies. We describe the importance of molecular and immunohistochemical methods in establishing the postmortem diagnosis of locally acquired Israeli spotted fever due to Rickettsia conorii subsp. israelensis in a traveler returning to Israel from India.

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Related in: MedlinePlus

A small vessel in the kidney (A) and a capillary in the cerbral cortex (B) positive with immunohistochemical stain specific for spotted fever group rickettsiae. Original magnification ×158.
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Figure 1: A small vessel in the kidney (A) and a capillary in the cerbral cortex (B) positive with immunohistochemical stain specific for spotted fever group rickettsiae. Original magnification ×158.

Mentions: Immunohistochemical staining performed at the Centers for Disease Control and Prevention (Atlanta, GA, USA) (3) showed spotted fever group rickettsiae in the vascular endothelial cells of the patient’s brain and kidney (Figure 1). Serologic tests for R. conorii from day 7 of illness yielded negative results (both immunoglobulin [Ig] M and IgG). On day 11 of illness, IgG results remained negative and IgM results were borderline positive (Table).


Fatal Rickettsia conorii subsp. israelensis infection, Israel.

Weinberger M, Keysary A, Sandbank J, Zaidenstein R, Itzhaki A, Strenger C, Leitner M, Paddock CD, Eremeeva ME - Emerging Infect. Dis. (2008)

A small vessel in the kidney (A) and a capillary in the cerbral cortex (B) positive with immunohistochemical stain specific for spotted fever group rickettsiae. Original magnification ×158.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600240&req=5

Figure 1: A small vessel in the kidney (A) and a capillary in the cerbral cortex (B) positive with immunohistochemical stain specific for spotted fever group rickettsiae. Original magnification ×158.
Mentions: Immunohistochemical staining performed at the Centers for Disease Control and Prevention (Atlanta, GA, USA) (3) showed spotted fever group rickettsiae in the vascular endothelial cells of the patient’s brain and kidney (Figure 1). Serologic tests for R. conorii from day 7 of illness yielded negative results (both immunoglobulin [Ig] M and IgG). On day 11 of illness, IgG results remained negative and IgM results were borderline positive (Table).

Bottom Line: Underdiagnosis of fatal spotted fever may be attributed to nonspecific clinical features and insensitive acute-phase serologic studies.We describe the importance of molecular and immunohistochemical methods in establishing the postmortem diagnosis of locally acquired Israeli spotted fever due to Rickettsia conorii subsp. israelensis in a traveler returning to Israel from India.

View Article: PubMed Central - PubMed

Affiliation: Infectious Diseases Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel. miriw@netvision.net.il

ABSTRACT
Underdiagnosis of fatal spotted fever may be attributed to nonspecific clinical features and insensitive acute-phase serologic studies. We describe the importance of molecular and immunohistochemical methods in establishing the postmortem diagnosis of locally acquired Israeli spotted fever due to Rickettsia conorii subsp. israelensis in a traveler returning to Israel from India.

Show MeSH
Related in: MedlinePlus