Sandfly fever Sicilian virus, Algeria.
Bottom Line: A sequence closely related to that of SFSV was detected in a Phlebotomus ariasi sandfly.Of 60 human serum samples, 3 contained immunoglobulin G against SFSV.These data suggest SFSV is present in Algeria.
Affiliation: Université Paris 13, Bobigny, France.
To determine whether sandfly fever Sicilian virus (SFSV) is present in Algeria, we tested sandflies for phlebovirus RNA. A sequence closely related to that of SFSV was detected in a Phlebotomus ariasi sandfly. Of 60 human serum samples, 3 contained immunoglobulin G against SFSV. These data suggest SFSV is present in Algeria.
Related in: MedlinePlus
Mentions: Together with homologous sequences of selected phleboviruses, the 3 sequences determined in this study were used to perform genetic distance comparison and phylogenetic analysis. Nucleotide and amino acid distances are presented in the Table. Distance analysis unambiguously indicated that Algeria virus is a variant genotype of SFSV. The same conclusion applied to Cyprus phlebovirus. These 3 viruses exhibited amino acid and nucleotide distances of <9.3% and <7.5%, respectively. Phylogenetic analyses (Figure 2) indicated that Algeria formed a strong cluster (100% bootstrap support) with SFSV strain Sabin and the Cyprus phlebovirus. Therefore, we propose that they can be considered as 3 variant strains of the tentative species SFSV. Because sandfly material was stored in a chaotropic solution, virus isolation was not possible, which will necessitate field work with storage conditions suitable for virus isolation attempts.