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Increasing hospitalizations and general practice prescriptions for community-onset staphylococcal disease, England.

Hayward A, Knott F, Petersen I, Livermore DM, Duckworth G, Islam A, Johnson AM - Emerging Infect. Dis. (2008)

Bottom Line: Admission rates increased 3-fold for abscesses and cellulitis and 1.5-fold for bone and joint infections.In primary care settings during 1991-2006, floxacillin prescriptions increased 1.8-fold and fusidic acidprescriptions 2.5-fold.We identified a previously undescribed but major increase in pathogenic community-onset staphylococcal disease over the past 15 years.

View Article: PubMed Central - PubMed

Affiliation: University College London Centre for Infectious Disease Epidemiology, London, UK. a.hayward@pcps.ucl.ac.uk

ABSTRACT
Rates of hospital-acquired staphylococcal infection increased throughout the 1990s; however, information is limited on trends in community-onset staphylococcal disease in the United Kingdom. We used Hospital Episode Statistics to describe trends in hospital admissions for community-onset staphylococcal disease and national general practice data to describe trends in community prescribing for staphylococcal disease. Hospital admission rates for staphyloccocal septicemia, staphylococcal pneumonia, staphylococcal scalded-skin syndrome, and impetigo increased >5-fold. Admission rates increased 3-fold for abscesses and cellulitis and 1.5-fold for bone and joint infections. In primary care settings during 1991-2006, floxacillin prescriptions increased 1.8-fold and fusidic acidprescriptions 2.5-fold. The increases were not matched by increases in admission rates for control conditions. We identified a previously undescribed but major increase in pathogenic community-onset staphylococcal disease over the past 15 years. These trends are of concern given the international emergence of invasive community-onset staphylococcal infections.

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Related in: MedlinePlus

Crude general practitioner (GP) prescription rates (per 100 population), England, 1991–2006.
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Figure 2: Crude general practitioner (GP) prescription rates (per 100 population), England, 1991–2006.

Mentions: On the basis of PACT data, a major increase in prescribing for staphylococcal disease by general practitioners was evident (Figure 2). The floxacillin prescribing rate per 100 population was 4.0 prescriptions in 1991 and 7.3 in 2006 (a 1.8-fold increase). The fusidic acid prescription rate per 100 persons was 2.0 in 1991 and 5.0 in 2006 (a 2.5-fold increase).


Increasing hospitalizations and general practice prescriptions for community-onset staphylococcal disease, England.

Hayward A, Knott F, Petersen I, Livermore DM, Duckworth G, Islam A, Johnson AM - Emerging Infect. Dis. (2008)

Crude general practitioner (GP) prescription rates (per 100 population), England, 1991–2006.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600225&req=5

Figure 2: Crude general practitioner (GP) prescription rates (per 100 population), England, 1991–2006.
Mentions: On the basis of PACT data, a major increase in prescribing for staphylococcal disease by general practitioners was evident (Figure 2). The floxacillin prescribing rate per 100 population was 4.0 prescriptions in 1991 and 7.3 in 2006 (a 1.8-fold increase). The fusidic acid prescription rate per 100 persons was 2.0 in 1991 and 5.0 in 2006 (a 2.5-fold increase).

Bottom Line: Admission rates increased 3-fold for abscesses and cellulitis and 1.5-fold for bone and joint infections.In primary care settings during 1991-2006, floxacillin prescriptions increased 1.8-fold and fusidic acidprescriptions 2.5-fold.We identified a previously undescribed but major increase in pathogenic community-onset staphylococcal disease over the past 15 years.

View Article: PubMed Central - PubMed

Affiliation: University College London Centre for Infectious Disease Epidemiology, London, UK. a.hayward@pcps.ucl.ac.uk

ABSTRACT
Rates of hospital-acquired staphylococcal infection increased throughout the 1990s; however, information is limited on trends in community-onset staphylococcal disease in the United Kingdom. We used Hospital Episode Statistics to describe trends in hospital admissions for community-onset staphylococcal disease and national general practice data to describe trends in community prescribing for staphylococcal disease. Hospital admission rates for staphyloccocal septicemia, staphylococcal pneumonia, staphylococcal scalded-skin syndrome, and impetigo increased >5-fold. Admission rates increased 3-fold for abscesses and cellulitis and 1.5-fold for bone and joint infections. In primary care settings during 1991-2006, floxacillin prescriptions increased 1.8-fold and fusidic acidprescriptions 2.5-fold. The increases were not matched by increases in admission rates for control conditions. We identified a previously undescribed but major increase in pathogenic community-onset staphylococcal disease over the past 15 years. These trends are of concern given the international emergence of invasive community-onset staphylococcal infections.

Show MeSH
Related in: MedlinePlus