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Streptococcus pneumoniae serotype 19A in children, South Korea.

Choi EH, Kim SH, Eun BW, Kim SJ, Kim NH, Lee J, Lee HJ - Emerging Infect. Dis. (2008)

Bottom Line: Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased.Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend).This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.

View Article: PubMed Central - PubMed

Affiliation: Seoul National University College of Medicine, Seoul, South Korea.

ABSTRACT
Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, serotype 19A was increasingly recognized in Korean children before the introduction of PCV7. To understand the dynamics of serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup 19 isolates (n = 126) were characterized by antimicrobial drug susceptibility, presence of mefA/ermB, and multilocus sequence typing. Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased. Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.

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Relationship of 126 strains of serogroup 19 by eBURST analysis. ST271 (blue circle) is the predicted primary founder and ST236 (yellow circle) was assigned to a subgroup founder. Numbers on the diagram correspond to sequence types (STs). The size of each circle correlates with the number of isolates of that ST. *Newly identified ST in this study.
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Figure 3: Relationship of 126 strains of serogroup 19 by eBURST analysis. ST271 (blue circle) is the predicted primary founder and ST236 (yellow circle) was assigned to a subgroup founder. Numbers on the diagram correspond to sequence types (STs). The size of each circle correlates with the number of isolates of that ST. *Newly identified ST in this study.

Mentions: According to eBURST analysis, 1 major CC (CC271) accounted for most of the isolates (n = 116, 92% of serotypes 19A and 19F). CC271 comprised 16 STs, where ST271 was predicted as the founder, and ST320 was the predominant allelic profile. The 5 ST lineages that were unrelated to CC271 were nonlinked singlets (ST1203, ST1374, ST2394, ST2395, and ST2399) (Figure 3).


Streptococcus pneumoniae serotype 19A in children, South Korea.

Choi EH, Kim SH, Eun BW, Kim SJ, Kim NH, Lee J, Lee HJ - Emerging Infect. Dis. (2008)

Relationship of 126 strains of serogroup 19 by eBURST analysis. ST271 (blue circle) is the predicted primary founder and ST236 (yellow circle) was assigned to a subgroup founder. Numbers on the diagram correspond to sequence types (STs). The size of each circle correlates with the number of isolates of that ST. *Newly identified ST in this study.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600206&req=5

Figure 3: Relationship of 126 strains of serogroup 19 by eBURST analysis. ST271 (blue circle) is the predicted primary founder and ST236 (yellow circle) was assigned to a subgroup founder. Numbers on the diagram correspond to sequence types (STs). The size of each circle correlates with the number of isolates of that ST. *Newly identified ST in this study.
Mentions: According to eBURST analysis, 1 major CC (CC271) accounted for most of the isolates (n = 116, 92% of serotypes 19A and 19F). CC271 comprised 16 STs, where ST271 was predicted as the founder, and ST320 was the predominant allelic profile. The 5 ST lineages that were unrelated to CC271 were nonlinked singlets (ST1203, ST1374, ST2394, ST2395, and ST2399) (Figure 3).

Bottom Line: Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased.Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend).This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.

View Article: PubMed Central - PubMed

Affiliation: Seoul National University College of Medicine, Seoul, South Korea.

ABSTRACT
Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, serotype 19A was increasingly recognized in Korean children before the introduction of PCV7. To understand the dynamics of serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup 19 isolates (n = 126) were characterized by antimicrobial drug susceptibility, presence of mefA/ermB, and multilocus sequence typing. Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased. Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.

Show MeSH
Related in: MedlinePlus