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Diagnosis of cystic echinococcosis, central Peruvian Highlands.

Gavidia CM, Gonzalez AE, Zhang W, McManus DP, Lopera L, Ninaquispe B, Garcia HH, Rodríguez S, Verastegui M, Calderon C, Pan WK, Gilman RH - Emerging Infect. Dis. (2008)

Bottom Line: For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively.Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively.We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

View Article: PubMed Central - PubMed

Affiliation: Universidad Nacional Mayor de San Marcos, San Borja, Lima, Peru. cgavidia@jhsph.edu

ABSTRACT
We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

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Ultrasonographic images of cystic echinococcosis in the liver in patients from the Yanahuanca district, Central Peruvian Highlands. A) Cyst type CE1; B) Cyst type CE2; C) Cyst type CE4.
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Figure 2: Ultrasonographic images of cystic echinococcosis in the liver in patients from the Yanahuanca district, Central Peruvian Highlands. A) Cyst type CE1; B) Cyst type CE2; C) Cyst type CE4.

Mentions: The total number of liver cysts was 50 (5 persons had 2 liver cysts each); the total number of lung cysts was 10 in 9 persons. The lung-to-liver ratio was 1:5. Most of the liver cysts were classified as CE5 (54%, 27/50), inactive cysts with calcified walls, followed by CE1 (20%, 10/50) active cysts and CE2 (10%, 5/50). Types CE3 and CE4 with signs of initial degeneration (8% each, 4/50) were rare (Figure 2). The average age was similar for persons with CE1, CE4, and CE5 at 40.6, 40.9, and 40 years of age, respectively. Those with CE2 and CE3 averaged 28.8 and 23.3 years of age, respectively.


Diagnosis of cystic echinococcosis, central Peruvian Highlands.

Gavidia CM, Gonzalez AE, Zhang W, McManus DP, Lopera L, Ninaquispe B, Garcia HH, Rodríguez S, Verastegui M, Calderon C, Pan WK, Gilman RH - Emerging Infect. Dis. (2008)

Ultrasonographic images of cystic echinococcosis in the liver in patients from the Yanahuanca district, Central Peruvian Highlands. A) Cyst type CE1; B) Cyst type CE2; C) Cyst type CE4.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600205&req=5

Figure 2: Ultrasonographic images of cystic echinococcosis in the liver in patients from the Yanahuanca district, Central Peruvian Highlands. A) Cyst type CE1; B) Cyst type CE2; C) Cyst type CE4.
Mentions: The total number of liver cysts was 50 (5 persons had 2 liver cysts each); the total number of lung cysts was 10 in 9 persons. The lung-to-liver ratio was 1:5. Most of the liver cysts were classified as CE5 (54%, 27/50), inactive cysts with calcified walls, followed by CE1 (20%, 10/50) active cysts and CE2 (10%, 5/50). Types CE3 and CE4 with signs of initial degeneration (8% each, 4/50) were rare (Figure 2). The average age was similar for persons with CE1, CE4, and CE5 at 40.6, 40.9, and 40 years of age, respectively. Those with CE2 and CE3 averaged 28.8 and 23.3 years of age, respectively.

Bottom Line: For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively.Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively.We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

View Article: PubMed Central - PubMed

Affiliation: Universidad Nacional Mayor de San Marcos, San Borja, Lima, Peru. cgavidia@jhsph.edu

ABSTRACT
We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.

Show MeSH
Related in: MedlinePlus