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Burkholderia pseudomallei antibodies in children, Cambodia.

Wuthiekanun V, Pheaktra N, Putchhat H, Sin L, Sen B, Kumar V, Langla S, Peacock SJ, Day NP - Emerging Infect. Dis. (2008)

Bottom Line: Antibodies to Burkholderia pseudomallei were detected in 16% of children in Siem Reap, Cambodia.This organism was isolated from 30% of rice paddies in the surrounding vicinity.Despite the lack of reported indigenous cases, melioidosis is likely to occur in Cambodia.

View Article: PubMed Central - PubMed

Affiliation: Mahidol University, Bangkok, Thailand. lek@tropmedres.ac

ABSTRACT
Antibodies to Burkholderia pseudomallei were detected in 16% of children in Siem Reap, Cambodia. This organism was isolated from 30% of rice paddies in the surrounding vicinity. Despite the lack of reported indigenous cases, melioidosis is likely to occur in Cambodia.

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Related in: MedlinePlus

Indirect hemagglutination assay (IHA) titer for 968 children living in Siem Reap, Cambodia. The number of children tested in each year group is shown. The number of children by age group follows: <1 y, 106 children; 1 y, 98 children; 2 y, 93 children; 3 y, 54 children; 4 y, 50 children; 5 y, 62 children; 6 y, 55 children; 7 y, 57 children; 8 y, 44 children; 9 y, 49 children; 10 y, 50 children; 11 y, 41 children; 12 y, 49 children; 13 y, 66 children; 14 y, 54 children; 15 y, 23 children; 16 y, 17 children.
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Figure 1: Indirect hemagglutination assay (IHA) titer for 968 children living in Siem Reap, Cambodia. The number of children tested in each year group is shown. The number of children by age group follows: <1 y, 106 children; 1 y, 98 children; 2 y, 93 children; 3 y, 54 children; 4 y, 50 children; 5 y, 62 children; 6 y, 55 children; 7 y, 57 children; 8 y, 44 children; 9 y, 49 children; 10 y, 50 children; 11 y, 41 children; 12 y, 49 children; 13 y, 66 children; 14 y, 54 children; 15 y, 23 children; 16 y, 17 children.

Mentions: Serum samples were obtained from 968 children, of whom 528 (54.5%) were male. The number of samples collected per year group is shown in the Figure. Fewer serum samples were collected from children 15 and 16 years of age because only a small number of samples were available from these age groups. A total of 159 children (16.4%) had a detectable IHA titer; values ranged from 10 to 10,240 (median 10, interquartile range [IQR] 20–640). Females were more likely to have a detectable IHA titer than males (86/440 females [19.5%] vs. 73/528 males [13.8%], p = 0.02), but the distribution of titer values in the population of positive female children was not significantly different from that in the population of positive male children. The proportion of children with any detectable IHA titer rose with age (Figure). An IHA titer >160 is used in some centers in Thailand to support a diagnosis of melioidosis in patients with clinical features consistent with this diagnosis. Sixty-three children (6.5%) had an IHA titer >160.


Burkholderia pseudomallei antibodies in children, Cambodia.

Wuthiekanun V, Pheaktra N, Putchhat H, Sin L, Sen B, Kumar V, Langla S, Peacock SJ, Day NP - Emerging Infect. Dis. (2008)

Indirect hemagglutination assay (IHA) titer for 968 children living in Siem Reap, Cambodia. The number of children tested in each year group is shown. The number of children by age group follows: <1 y, 106 children; 1 y, 98 children; 2 y, 93 children; 3 y, 54 children; 4 y, 50 children; 5 y, 62 children; 6 y, 55 children; 7 y, 57 children; 8 y, 44 children; 9 y, 49 children; 10 y, 50 children; 11 y, 41 children; 12 y, 49 children; 13 y, 66 children; 14 y, 54 children; 15 y, 23 children; 16 y, 17 children.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600196&req=5

Figure 1: Indirect hemagglutination assay (IHA) titer for 968 children living in Siem Reap, Cambodia. The number of children tested in each year group is shown. The number of children by age group follows: <1 y, 106 children; 1 y, 98 children; 2 y, 93 children; 3 y, 54 children; 4 y, 50 children; 5 y, 62 children; 6 y, 55 children; 7 y, 57 children; 8 y, 44 children; 9 y, 49 children; 10 y, 50 children; 11 y, 41 children; 12 y, 49 children; 13 y, 66 children; 14 y, 54 children; 15 y, 23 children; 16 y, 17 children.
Mentions: Serum samples were obtained from 968 children, of whom 528 (54.5%) were male. The number of samples collected per year group is shown in the Figure. Fewer serum samples were collected from children 15 and 16 years of age because only a small number of samples were available from these age groups. A total of 159 children (16.4%) had a detectable IHA titer; values ranged from 10 to 10,240 (median 10, interquartile range [IQR] 20–640). Females were more likely to have a detectable IHA titer than males (86/440 females [19.5%] vs. 73/528 males [13.8%], p = 0.02), but the distribution of titer values in the population of positive female children was not significantly different from that in the population of positive male children. The proportion of children with any detectable IHA titer rose with age (Figure). An IHA titer >160 is used in some centers in Thailand to support a diagnosis of melioidosis in patients with clinical features consistent with this diagnosis. Sixty-three children (6.5%) had an IHA titer >160.

Bottom Line: Antibodies to Burkholderia pseudomallei were detected in 16% of children in Siem Reap, Cambodia.This organism was isolated from 30% of rice paddies in the surrounding vicinity.Despite the lack of reported indigenous cases, melioidosis is likely to occur in Cambodia.

View Article: PubMed Central - PubMed

Affiliation: Mahidol University, Bangkok, Thailand. lek@tropmedres.ac

ABSTRACT
Antibodies to Burkholderia pseudomallei were detected in 16% of children in Siem Reap, Cambodia. This organism was isolated from 30% of rice paddies in the surrounding vicinity. Despite the lack of reported indigenous cases, melioidosis is likely to occur in Cambodia.

Show MeSH
Related in: MedlinePlus