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Severe Streptococcus pyogenes infections, United Kingdom, 2003-2004.

Lamagni TL, Neal S, Keshishian C, Alhaddad N, George R, Duckworth G, Vuopio-Varkila J, Efstratiou A - Emerging Infect. Dis. (2008)

Bottom Line: Injection drug use was identified as a risk factor for 20% of case-patients.One in 5 infected case-patients died within 7 days of diagnosis; the highest mortality rate was for cases of necrotizing fasciitis (34%).Understanding the pattern of these diseases and predictors of poor patient outcome will help with identification and assessment of the potential effect of targeted interventions.

View Article: PubMed Central - PubMed

Affiliation: Health Protection Agency, London, United Kingdom. theresa.lamagni@hpa.org.uk

ABSTRACT
As part of a Europe-wide initiative to explore current epidemiologic patterns of severe disease caused by Streptococcus pyogenes, the United Kingdom undertook enhanced population-based surveillance during 2003-2004. A total of 3,775 confirmed cases of severe S. pyogenes infection were identified over 2 years, 3.33/100,000 population, substantially more than previously estimated. Skin/soft tissue infections were the most common manifestation (42%), followed by respiratory tract infections (17%). Injection drug use was identified as a risk factor for 20% of case-patients. One in 5 infected case-patients died within 7 days of diagnosis; the highest mortality rate was for cases of necrotizing fasciitis (34%). Nonsteroidal antiinflammatory drugs, alcoholism, young age, and infection with emm/M3 types were independently associated with increased risk for streptococcal toxic shock syndrome. Understanding the pattern of these diseases and predictors of poor patient outcome will help with identification and assessment of the potential effect of targeted interventions.

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Related in: MedlinePlus

Seasonal trends in reports of severe Streptococcus pyogenes infection in the United Kingdom, 2003–2004. Moving average (6 wk) is the average count for the previous 6 weeks.
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Figure 2: Seasonal trends in reports of severe Streptococcus pyogenes infection in the United Kingdom, 2003–2004. Moving average (6 wk) is the average count for the previous 6 weeks.

Mentions: Marked seasonal peaks of severe S. pyogenes infection were observed in both years. Cases gradually increased from the end of October and first peaked near the end of January (2nd week of 2003, 51 cases; 4th week of 2004, 60 cases) before peaking again (higher) toward the end of March (12th week of 2003, 62 cases; 14th week of 2004, 64 cases) (Figure 2).


Severe Streptococcus pyogenes infections, United Kingdom, 2003-2004.

Lamagni TL, Neal S, Keshishian C, Alhaddad N, George R, Duckworth G, Vuopio-Varkila J, Efstratiou A - Emerging Infect. Dis. (2008)

Seasonal trends in reports of severe Streptococcus pyogenes infection in the United Kingdom, 2003–2004. Moving average (6 wk) is the average count for the previous 6 weeks.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600190&req=5

Figure 2: Seasonal trends in reports of severe Streptococcus pyogenes infection in the United Kingdom, 2003–2004. Moving average (6 wk) is the average count for the previous 6 weeks.
Mentions: Marked seasonal peaks of severe S. pyogenes infection were observed in both years. Cases gradually increased from the end of October and first peaked near the end of January (2nd week of 2003, 51 cases; 4th week of 2004, 60 cases) before peaking again (higher) toward the end of March (12th week of 2003, 62 cases; 14th week of 2004, 64 cases) (Figure 2).

Bottom Line: Injection drug use was identified as a risk factor for 20% of case-patients.One in 5 infected case-patients died within 7 days of diagnosis; the highest mortality rate was for cases of necrotizing fasciitis (34%).Understanding the pattern of these diseases and predictors of poor patient outcome will help with identification and assessment of the potential effect of targeted interventions.

View Article: PubMed Central - PubMed

Affiliation: Health Protection Agency, London, United Kingdom. theresa.lamagni@hpa.org.uk

ABSTRACT
As part of a Europe-wide initiative to explore current epidemiologic patterns of severe disease caused by Streptococcus pyogenes, the United Kingdom undertook enhanced population-based surveillance during 2003-2004. A total of 3,775 confirmed cases of severe S. pyogenes infection were identified over 2 years, 3.33/100,000 population, substantially more than previously estimated. Skin/soft tissue infections were the most common manifestation (42%), followed by respiratory tract infections (17%). Injection drug use was identified as a risk factor for 20% of case-patients. One in 5 infected case-patients died within 7 days of diagnosis; the highest mortality rate was for cases of necrotizing fasciitis (34%). Nonsteroidal antiinflammatory drugs, alcoholism, young age, and infection with emm/M3 types were independently associated with increased risk for streptococcal toxic shock syndrome. Understanding the pattern of these diseases and predictors of poor patient outcome will help with identification and assessment of the potential effect of targeted interventions.

Show MeSH
Related in: MedlinePlus