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International Circumpolar Surveillance System for invasive pneumococcal disease, 1999-2005.

Bruce MG, Deeks SL, Zulz T, Bruden D, Navarro C, Lovgren M, Jette L, Kristinsson K, Sigmundsdottir G, Jensen KB, Lovoll O, Nuorti JP, Herva E, Nystedt A, Sjostedt A, Koch A, Hennessy TW, Parkinson AJ - Emerging Infect. Dis. (2008)

Bottom Line: In Alaska and northern Canada, IPD rates in children <2 years of age caused by PCV7 serotypes decreased by >80% after routine vaccination.IPD rates are high among indigenous persons and children in Arctic countries.After vaccine introduction, IPD caused by non-PCV7 serotypes increased in Alaska.

View Article: PubMed Central - PubMed

Affiliation: Arctic Investigations Program, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Circle Drive, Anchorage, AK 99508, USA. zwa8@cdc.gov

ABSTRACT
The International Circumpolar Surveillance System is a population-based surveillance network for invasive bacterial disease in the Arctic. The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced for routine infant vaccination in Alaska (2001), northern Canada (2002-2006), and Norway (2006). Data for invasive pneumococcal disease (IPD) were analyzed to identify clinical findings, disease rates, serotype distribution, and antimicrobial drug susceptibility; 11,244 IPD cases were reported. Pneumonia and bacteremia were common clinical findings. Rates of IPD among indigenous persons in Alaska and northern Canada were 43 and 38 cases per 100,000 population, respectively. Rates in children <2 years of age ranged from 21 to 153 cases per 100,000 population. In Alaska and northern Canada, IPD rates in children <2 years of age caused by PCV7 serotypes decreased by >80% after routine vaccination. IPD rates are high among indigenous persons and children in Arctic countries. After vaccine introduction, IPD caused by non-PCV7 serotypes increased in Alaska.

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Annual invasive pneumococcal disease rates among children <2 years of age by International Circumpolar Surveillance System member country, 1999–2005. The p values are for trend.
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Figure 1: Annual invasive pneumococcal disease rates among children <2 years of age by International Circumpolar Surveillance System member country, 1999–2005. The p values are for trend.

Mentions: In Alaska, incidence of IPD among all age groups decreased from 20.6 cases in the prevaccine period (1999–2000) to 15.8 cases/100,000 persons in the postvaccine period (2001–2005; p = 0.0004). Among Alaskan children <2 years of age, incidence of IPD decreased from 173.5 cases in the pre–conjugate vaccine period to 79.2 cases/100,000 children in the postvaccine period (p<0.0001). Similarly, in northern Canada, incidence of IPD among all age groups decreased from 31.0 cases/100,000 persons in the prevaccine period (1999–2002) to 21.6 cases/100,000 persons in the vaccine implementation period (2003–2005; p = 0.007) (Table 4). Among northern Canadian children <2 years of age, incidence of IPD had been decreasing in the 2 years before PCV7 use (Figure). The incidence of IPD decreased from 185.6 cases/100,000 children in the prevaccine period (1999–2002) to 110.0 cases/100,000 children in the vaccine implementation period (2003–2005), However, this decrease was not statistically significant (p = 0.10) (Table 4).


International Circumpolar Surveillance System for invasive pneumococcal disease, 1999-2005.

Bruce MG, Deeks SL, Zulz T, Bruden D, Navarro C, Lovgren M, Jette L, Kristinsson K, Sigmundsdottir G, Jensen KB, Lovoll O, Nuorti JP, Herva E, Nystedt A, Sjostedt A, Koch A, Hennessy TW, Parkinson AJ - Emerging Infect. Dis. (2008)

Annual invasive pneumococcal disease rates among children <2 years of age by International Circumpolar Surveillance System member country, 1999–2005. The p values are for trend.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600171&req=5

Figure 1: Annual invasive pneumococcal disease rates among children <2 years of age by International Circumpolar Surveillance System member country, 1999–2005. The p values are for trend.
Mentions: In Alaska, incidence of IPD among all age groups decreased from 20.6 cases in the prevaccine period (1999–2000) to 15.8 cases/100,000 persons in the postvaccine period (2001–2005; p = 0.0004). Among Alaskan children <2 years of age, incidence of IPD decreased from 173.5 cases in the pre–conjugate vaccine period to 79.2 cases/100,000 children in the postvaccine period (p<0.0001). Similarly, in northern Canada, incidence of IPD among all age groups decreased from 31.0 cases/100,000 persons in the prevaccine period (1999–2002) to 21.6 cases/100,000 persons in the vaccine implementation period (2003–2005; p = 0.007) (Table 4). Among northern Canadian children <2 years of age, incidence of IPD had been decreasing in the 2 years before PCV7 use (Figure). The incidence of IPD decreased from 185.6 cases/100,000 children in the prevaccine period (1999–2002) to 110.0 cases/100,000 children in the vaccine implementation period (2003–2005), However, this decrease was not statistically significant (p = 0.10) (Table 4).

Bottom Line: In Alaska and northern Canada, IPD rates in children <2 years of age caused by PCV7 serotypes decreased by >80% after routine vaccination.IPD rates are high among indigenous persons and children in Arctic countries.After vaccine introduction, IPD caused by non-PCV7 serotypes increased in Alaska.

View Article: PubMed Central - PubMed

Affiliation: Arctic Investigations Program, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Circle Drive, Anchorage, AK 99508, USA. zwa8@cdc.gov

ABSTRACT
The International Circumpolar Surveillance System is a population-based surveillance network for invasive bacterial disease in the Arctic. The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced for routine infant vaccination in Alaska (2001), northern Canada (2002-2006), and Norway (2006). Data for invasive pneumococcal disease (IPD) were analyzed to identify clinical findings, disease rates, serotype distribution, and antimicrobial drug susceptibility; 11,244 IPD cases were reported. Pneumonia and bacteremia were common clinical findings. Rates of IPD among indigenous persons in Alaska and northern Canada were 43 and 38 cases per 100,000 population, respectively. Rates in children <2 years of age ranged from 21 to 153 cases per 100,000 population. In Alaska and northern Canada, IPD rates in children <2 years of age caused by PCV7 serotypes decreased by >80% after routine vaccination. IPD rates are high among indigenous persons and children in Arctic countries. After vaccine introduction, IPD caused by non-PCV7 serotypes increased in Alaska.

Show MeSH
Related in: MedlinePlus