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Molecular epidemiology of dengue virus strains from Finnish travelers.

Huhtamo E, Uzcátegui NY, Siikamäki H, Saarinen A, Piiparinen H, Vaheri A, Vapalahti O - Emerging Infect. Dis. (2008)

Bottom Line: We characterized 11 dengue virus (DENV) isolates obtained from Finnish travelers during 2000-2005 using monoclonal antibodies and phylogenetic analysis.The analysis of DENV isolated from travelers contributes to the global picture of strain distribution and circulation.The isolates included all serotypes, including a DENV-2 isolate from Ghana.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, Helsinki, Finland. elli.huhtamo@helsinki.fi

ABSTRACT
We characterized 11 dengue virus (DENV) isolates obtained from Finnish travelers during 2000-2005 using monoclonal antibodies and phylogenetic analysis. The analysis of DENV isolated from travelers contributes to the global picture of strain distribution and circulation. The isolates included all serotypes, including a DENV-2 isolate from Ghana.

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Related in: MedlinePlus

Neighbor-joining phylogenetic tree of dengue virus type 2 (DENV-2) based on the envelope gene sequence (1,485 bp). Isolate 9 from Ghana is circled. Bar represents nucleotide substitutions/site.
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Figure 2: Neighbor-joining phylogenetic tree of dengue virus type 2 (DENV-2) based on the envelope gene sequence (1,485 bp). Isolate 9 from Ghana is circled. Bar represents nucleotide substitutions/site.

Mentions: Phylogenetic analyses (Figure 1) showed that isolates 3, 4, and 8 (DENV-1) clustered with Asiatic DENV-1 strains of genotype I (7), which corresponded with the patients’ travel history. Isolate 11 (DENV-1) from India clustered with a genotype III strain isolated a year earlier from the Seychelles. Isolate 6 (DENV-2), obtained from Sri Lanka in 2003, clustered with a strain isolated in the same year from India. Unlike the other isolates, isolate 9 (DENV-2), obtained in Ghana in 2005, did not group with any of the representative strains of the C-preM region, for which no African sequences were available in GenBank. The additionally studied envelope gene sequence grouped with previous African isolates of the cosmopolitan genotype (8) (Figure 2).


Molecular epidemiology of dengue virus strains from Finnish travelers.

Huhtamo E, Uzcátegui NY, Siikamäki H, Saarinen A, Piiparinen H, Vaheri A, Vapalahti O - Emerging Infect. Dis. (2008)

Neighbor-joining phylogenetic tree of dengue virus type 2 (DENV-2) based on the envelope gene sequence (1,485 bp). Isolate 9 from Ghana is circled. Bar represents nucleotide substitutions/site.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600155&req=5

Figure 2: Neighbor-joining phylogenetic tree of dengue virus type 2 (DENV-2) based on the envelope gene sequence (1,485 bp). Isolate 9 from Ghana is circled. Bar represents nucleotide substitutions/site.
Mentions: Phylogenetic analyses (Figure 1) showed that isolates 3, 4, and 8 (DENV-1) clustered with Asiatic DENV-1 strains of genotype I (7), which corresponded with the patients’ travel history. Isolate 11 (DENV-1) from India clustered with a genotype III strain isolated a year earlier from the Seychelles. Isolate 6 (DENV-2), obtained from Sri Lanka in 2003, clustered with a strain isolated in the same year from India. Unlike the other isolates, isolate 9 (DENV-2), obtained in Ghana in 2005, did not group with any of the representative strains of the C-preM region, for which no African sequences were available in GenBank. The additionally studied envelope gene sequence grouped with previous African isolates of the cosmopolitan genotype (8) (Figure 2).

Bottom Line: We characterized 11 dengue virus (DENV) isolates obtained from Finnish travelers during 2000-2005 using monoclonal antibodies and phylogenetic analysis.The analysis of DENV isolated from travelers contributes to the global picture of strain distribution and circulation.The isolates included all serotypes, including a DENV-2 isolate from Ghana.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, Helsinki, Finland. elli.huhtamo@helsinki.fi

ABSTRACT
We characterized 11 dengue virus (DENV) isolates obtained from Finnish travelers during 2000-2005 using monoclonal antibodies and phylogenetic analysis. The analysis of DENV isolated from travelers contributes to the global picture of strain distribution and circulation. The isolates included all serotypes, including a DENV-2 isolate from Ghana.

Show MeSH
Related in: MedlinePlus