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Sindbis virus infection in resident birds, migratory birds, and humans, Finland.

Kurkela S, Rätti O, Huhtamo E, Uzcátegui NY, Nuorti JP, Laakkonen J, Manni T, Helle P, Vaheri A, Vapalahti O - Emerging Infect. Dis. (2008)

Bottom Line: SINV antibodies were first found in 3 birds (red-backed shrike, robin, song thrush) during their spring migration to northern Europe.Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland).Grouse may contribute to the epidemiology of SINV in humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, Faculty of Medicine, Haartman Institute at the University of Helsinki, Haartmaninkatu 3, Helsinki, Finland. satu.kurkela@helsinki.fi

ABSTRACT
Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe. To gain a better understanding of SINV epidemiology in Finland, we searched for SINV antibodies in 621 resident grouse, whose population declines have coincided with human SINV outbreaks, and in 836 migratory birds. We used hemagglutination-inhibition and neutralization tests for the bird samples and enzyme immunoassays and hemagglutination-inhibition for the human samples. SINV antibodies were first found in 3 birds (red-backed shrike, robin, song thrush) during their spring migration to northern Europe. Of the grouse, 27.4% were seropositive in 2003 (1 year after a human outbreak), but only 1.4% were seropositive in 2004. Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland). Grouse may contribute to the epidemiology of SINV in humans.

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Average annualized incidence of Sindbis virus infection in human population, Finland, 1995–2003.
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Figure 3: Average annualized incidence of Sindbis virus infection in human population, Finland, 1995–2003.

Mentions: The incidence of SINV during epidemic years was 25.6/100,000/year in 1995 and 11.5/100,000/year in 2002 (Figure 1, panel B); the average annualized incidence in nonepidemic years (1996–2001 and 2003) was 2.4/100,000. The rates for women and men were 8.7 and 6.6/100,000, respectively. The average annualized incidence was highest (13.5/100,000) among persons 50–59 years of age (Figure 2). Rates were higher for persons in the eastern parts than in the central part of the country and were highest in North Karelia (25.7/100,000; Figure 1, panel C); incidence peaked in North Karelia and in southern Ostrobothnia during the 1995 and 2002 outbreaks (Figure 3). However, a year after the outbreak in 2003, the rates were twice as high in southern Ostrobothnia than in North Karelia (Figure 3).


Sindbis virus infection in resident birds, migratory birds, and humans, Finland.

Kurkela S, Rätti O, Huhtamo E, Uzcátegui NY, Nuorti JP, Laakkonen J, Manni T, Helle P, Vaheri A, Vapalahti O - Emerging Infect. Dis. (2008)

Average annualized incidence of Sindbis virus infection in human population, Finland, 1995–2003.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600146&req=5

Figure 3: Average annualized incidence of Sindbis virus infection in human population, Finland, 1995–2003.
Mentions: The incidence of SINV during epidemic years was 25.6/100,000/year in 1995 and 11.5/100,000/year in 2002 (Figure 1, panel B); the average annualized incidence in nonepidemic years (1996–2001 and 2003) was 2.4/100,000. The rates for women and men were 8.7 and 6.6/100,000, respectively. The average annualized incidence was highest (13.5/100,000) among persons 50–59 years of age (Figure 2). Rates were higher for persons in the eastern parts than in the central part of the country and were highest in North Karelia (25.7/100,000; Figure 1, panel C); incidence peaked in North Karelia and in southern Ostrobothnia during the 1995 and 2002 outbreaks (Figure 3). However, a year after the outbreak in 2003, the rates were twice as high in southern Ostrobothnia than in North Karelia (Figure 3).

Bottom Line: SINV antibodies were first found in 3 birds (red-backed shrike, robin, song thrush) during their spring migration to northern Europe.Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland).Grouse may contribute to the epidemiology of SINV in humans.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, Faculty of Medicine, Haartman Institute at the University of Helsinki, Haartmaninkatu 3, Helsinki, Finland. satu.kurkela@helsinki.fi

ABSTRACT
Sindbis virus (SINV), a mosquito-borne virus that causes rash and arthritis, has been causing outbreaks in humans every seventh year in northern Europe. To gain a better understanding of SINV epidemiology in Finland, we searched for SINV antibodies in 621 resident grouse, whose population declines have coincided with human SINV outbreaks, and in 836 migratory birds. We used hemagglutination-inhibition and neutralization tests for the bird samples and enzyme immunoassays and hemagglutination-inhibition for the human samples. SINV antibodies were first found in 3 birds (red-backed shrike, robin, song thrush) during their spring migration to northern Europe. Of the grouse, 27.4% were seropositive in 2003 (1 year after a human outbreak), but only 1.4% were seropositive in 2004. Among 2,529 persons, the age-standardized seroprevalence (1999-2003) was 5.2%; seroprevalence and incidence (1995-2003) were highest in North Karelia (eastern Finland). Grouse may contribute to the epidemiology of SINV in humans.

Show MeSH
Related in: MedlinePlus