Limits...
Streptococcus suis meningitis, United States.

Lee GT, Chiu CY, Haller BL, Denn PM, Hall CS, Gerberding JL - Emerging Infect. Dis. (2008)

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Streptococcus suis, commensal and opportunistic pathogens of swine, and prevalent zoonotic agents worldwide, are α-hemolytic gram-positive cocci with 35 different serotypes... In humans, S. suis infection has been associated with bacterial meningitis, septic shock, arthritis, pneumonia, endocarditis, endophthalmitis, and spontaneous bacterial peritonitis... The organism was catalase-negative, bile esculin-negative, and pyrrolidonyl aminopeptidase-negative, consistent with Streptococcus spp... A latex agglutination test did not detect Streptococcus pneumoniae antigen... The patient completed a 10-day course of parenteral antimicrobial drugs and was discharged on continued oral therapy with close followup... Two months after discharge, the patient reported much improved hearing without other sequelae... Most S. suis infections occur in older men and patients who report contact with pigs or eating undercooked pork products... Thus, empiric therapy for adult bacterial meningitis (ceftriaxone and vancomycin with or without ampicillin) would likely be sufficient to treat S. suis meningitis... S. suis infection may go unrecognized since many laboratories do not routinely speciate α-hemolytic streptococci... However, in the United States, specialized tests such as the API 20 Strep System (API System; La Balme Les Grottes, Montalieu-Vercieu, France) or reference laboratories are readily available for diagnosis of all unidentified streptococci... In countries that lack these resources and where undercooked pork is a diet staple, underdiagnosis of S. suis infection is likely... Greater understanding of this organism and its disease spectrum would promote earlier diagnosis and prevention of sequelae.

Show MeSH

Related in: MedlinePlus

Gram-positive cocci in pairs in a 60-year-old man with meningitis. Magnification ×1,000.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2600143&req=5

Figure 1: Gram-positive cocci in pairs in a 60-year-old man with meningitis. Magnification ×1,000.

Mentions: The patient described no recent contact with sick persons; past medical history was unremarkable. On physical examination, he was somnolent but fully oriented, with no focal findings on neurologic examination and only slight nuchal rigidity. He had a leukocyte count of 21,000/mm3, including 16,400/mm3 neutrophils. Cerebrospinal fluid (CSF) showed leukocyte count of 487/μL with 80% polymorphonuclear cells and 18% lymphocytes, and glucose and protein levels <20 mg/dL and <167 mg/dL, respectively. Gram stain of CSF showed gram-positive cocci in pairs (Figure). Empiric therapy (ceftriaxone, vancomycin, and ampicillin) for bacterial meningitis was begun. Computed tomographic scan of the head showed only sinusitis; findings of chest radiograph and transesophageal echocardiogram were negative.


Streptococcus suis meningitis, United States.

Lee GT, Chiu CY, Haller BL, Denn PM, Hall CS, Gerberding JL - Emerging Infect. Dis. (2008)

Gram-positive cocci in pairs in a 60-year-old man with meningitis. Magnification ×1,000.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600143&req=5

Figure 1: Gram-positive cocci in pairs in a 60-year-old man with meningitis. Magnification ×1,000.
Mentions: The patient described no recent contact with sick persons; past medical history was unremarkable. On physical examination, he was somnolent but fully oriented, with no focal findings on neurologic examination and only slight nuchal rigidity. He had a leukocyte count of 21,000/mm3, including 16,400/mm3 neutrophils. Cerebrospinal fluid (CSF) showed leukocyte count of 487/μL with 80% polymorphonuclear cells and 18% lymphocytes, and glucose and protein levels <20 mg/dL and <167 mg/dL, respectively. Gram stain of CSF showed gram-positive cocci in pairs (Figure). Empiric therapy (ceftriaxone, vancomycin, and ampicillin) for bacterial meningitis was begun. Computed tomographic scan of the head showed only sinusitis; findings of chest radiograph and transesophageal echocardiogram were negative.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Streptococcus suis, commensal and opportunistic pathogens of swine, and prevalent zoonotic agents worldwide, are α-hemolytic gram-positive cocci with 35 different serotypes... In humans, S. suis infection has been associated with bacterial meningitis, septic shock, arthritis, pneumonia, endocarditis, endophthalmitis, and spontaneous bacterial peritonitis... The organism was catalase-negative, bile esculin-negative, and pyrrolidonyl aminopeptidase-negative, consistent with Streptococcus spp... A latex agglutination test did not detect Streptococcus pneumoniae antigen... The patient completed a 10-day course of parenteral antimicrobial drugs and was discharged on continued oral therapy with close followup... Two months after discharge, the patient reported much improved hearing without other sequelae... Most S. suis infections occur in older men and patients who report contact with pigs or eating undercooked pork products... Thus, empiric therapy for adult bacterial meningitis (ceftriaxone and vancomycin with or without ampicillin) would likely be sufficient to treat S. suis meningitis... S. suis infection may go unrecognized since many laboratories do not routinely speciate α-hemolytic streptococci... However, in the United States, specialized tests such as the API 20 Strep System (API System; La Balme Les Grottes, Montalieu-Vercieu, France) or reference laboratories are readily available for diagnosis of all unidentified streptococci... In countries that lack these resources and where undercooked pork is a diet staple, underdiagnosis of S. suis infection is likely... Greater understanding of this organism and its disease spectrum would promote earlier diagnosis and prevention of sequelae.

Show MeSH
Related in: MedlinePlus