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Adamantane-resistant influenza infection during the 2004-05 season.

Rahman M, Bright RA, Kieke BA, Donahue JG, Greenlee RT, Vandermause M, Balish A, Foust A, Cox NJ, Klimov AI, Shay DK, Belongia EA - Emerging Infect. Dis. (2008)

Bottom Line: Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared.We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005.The prevalence of resistance was highest in children.

View Article: PubMed Central - PubMed

Affiliation: Epidemiology Research Center (ML2), Marshfield Clinic Research Foundation, 1000 N. Oak Avenue, Marshfield, WI 54449, USA.

ABSTRACT
Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared. We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005. Resistant and susceptible viruses caused similar symptoms and illness duration. The prevalence of resistance was highest in children.

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Results of patient recruitment and influenza cultures. *One isolate was not characterized.
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Figure 1: Results of patient recruitment and influenza cultures. *One isolate was not characterized.

Mentions: Influenza virus was isolated in 167 (20%) of 818 cultures from ill cohort members; 153 (92%) were influenza A (H3N2) and 14 (8%) were influenza B (Figure). Influenza A (H1N1) was not isolated from any patients. Adamantane resistance was present in 72 (47%) of 152 influenza A isolates; 1 additional isolate was not characterized. All resistant isolates contained a point mutation resulting in a serine to asparagine change at amino acid 31 (S31N) of the M2 protein. The median age was 43.6 years among patients with resistant isolates and 64.7 years among those with susceptible isolates (p = 0.002). The proportion of patients with adamantane-resistant viruses was significantly higher in 6- to 23-month-old children (70%) compared with adults >65 years of age (39%) (unadjusted prevalence ratio 1.8; 95% confidence interval [CI] 1.2–2.6; p = 0.003).


Adamantane-resistant influenza infection during the 2004-05 season.

Rahman M, Bright RA, Kieke BA, Donahue JG, Greenlee RT, Vandermause M, Balish A, Foust A, Cox NJ, Klimov AI, Shay DK, Belongia EA - Emerging Infect. Dis. (2008)

Results of patient recruitment and influenza cultures. *One isolate was not characterized.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2600142&req=5

Figure 1: Results of patient recruitment and influenza cultures. *One isolate was not characterized.
Mentions: Influenza virus was isolated in 167 (20%) of 818 cultures from ill cohort members; 153 (92%) were influenza A (H3N2) and 14 (8%) were influenza B (Figure). Influenza A (H1N1) was not isolated from any patients. Adamantane resistance was present in 72 (47%) of 152 influenza A isolates; 1 additional isolate was not characterized. All resistant isolates contained a point mutation resulting in a serine to asparagine change at amino acid 31 (S31N) of the M2 protein. The median age was 43.6 years among patients with resistant isolates and 64.7 years among those with susceptible isolates (p = 0.002). The proportion of patients with adamantane-resistant viruses was significantly higher in 6- to 23-month-old children (70%) compared with adults >65 years of age (39%) (unadjusted prevalence ratio 1.8; 95% confidence interval [CI] 1.2–2.6; p = 0.003).

Bottom Line: Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared.We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005.The prevalence of resistance was highest in children.

View Article: PubMed Central - PubMed

Affiliation: Epidemiology Research Center (ML2), Marshfield Clinic Research Foundation, 1000 N. Oak Avenue, Marshfield, WI 54449, USA.

ABSTRACT
Adamantane-resistant influenza A is an emerging problem, but infections caused by resistant and susceptible viruses have not been compared. We identified adamantane resistance in 47% of 152 influenza A virus (H3N2) isolates collected during 2005. Resistant and susceptible viruses caused similar symptoms and illness duration. The prevalence of resistance was highest in children.

Show MeSH
Related in: MedlinePlus